Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Randy S. Bethiel"'
Autor:
Michael J. Boyd, Nti-Addae Kwame Wiredu, Randy S. Bethiel, John P. Duffy, Joshua R. Leeman, Rene Rijnbrand, Brian Ledford, Deng Hongbo, Christine Memmott, Tiansheng Wang, Randal Byrn, Hamilton B. Bennett, Luc J. Farmer, Jones Steven, Wenxin Gu, Paul S. Charifson, Youssef L. Bennani, Mark W. Ledeboer, Upul K. Bandarage, Marc Jacobs, Michael P. Clark, Emanuele Perola, Colleen O’Brien, Alice Tsai, Shannon Dean
In our efforts to develop novel small-molecule inhibitors for the treatment of influenza, we utilized molecular modeling and the X-ray crystal structure of the PB2 subunit of the influenza polymerase to optimize a series of acyclic β-amino acid inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571e3924c774ac8afe409ad89fb6f678
https://europepmc.org/articles/PMC5304291/
https://europepmc.org/articles/PMC5304291/
Autor:
David Messersmith, Harmon J. Zuccola, Thomas Hoock, Sudipta Mahajan, Christopher Town, M. Woods Wannamaker, Luke Oh, Jian Wang, James J. Black, Bin Fan, Pamela McCarthy, Francesco G. Salituro, Mark N. Namchuk, Christopher L Brummel, Valerie Marone, Warren Dorsch, Randy S. Bethiel, Mark W. Ledeboer, Edmund Harrington, Summer Halas, Dina Shlyakter, Lora Swenson, Cochran John E, Youssef L. Bennani, Arthur Rugg, David Howe, Albert C. Pierce, Shannon Dean, Marina Penney, Hui Huang, Tiansheng Wang, Gabriel Martinez-Botella, James K. Hogan, Ananthsrinivas Chakilam, Shengkai Liao, Michael J. Arnost, Kumkum Saxena, Luc J. Farmer, Scott A. Raybuck, Shi-Kai Tian, Dylan Jacobs, Leena Laitinen, Raymond J. Winquist
Publikováno v:
Journal of medicinal chemistry. 58(18)
While several therapeutic options exist, the need for more effective, safe, and convenient treatment for a variety of autoimmune diseases persists. Targeting the Janus tyrosine kinases (JAKs), which play essential roles in cell signaling responses an
Autor:
Marc Jacobs, Christopher Bral, Youssef L. Bennani, Jianglin Liang, John P. Duffy, Tiansheng Wang, Brian Ledford, Michael J. Boyd, Wenxin Gu, Randal Byrn, Min Jiang, Christine Memmott, Azin Nezami, Ioana Davies, Joshua R. Leeman, Yuegang Zhang, Hamilton B. Bennett, Warren Dorsch, Katrina L. Jackson, Upul K. Bandarage, William P. Taylor, Mark W. Ledeboer, Dylan Jacobs, Francesco G. Salituro, Kennedy Joseph M, Huai Gao, Nti-Addae Kwame Wiredu, Michael P. Clark, Francois Maltais, Emanuele Perola, Murcko Mark A, Deng Hongbo, M. Woods Wannamaker, Ursula A. Germann, Alice Tsai, Rene Rijnbrand, Luc J. Farmer, Colleen F. McNeil, Randy S. Bethiel, Paul S. Charifson, John J. Court, Jones Steven
Publikováno v:
Journal of medicinal chemistry. 57(15)
In our effort to develop agents for the treatment of influenza, a phenotypic screening approach utilizing a cell protection assay identified a series of azaindole based inhibitors of the cap-snatching function of the PB2 subunit of the influenza A vi
Autor:
Luc J. Farmer, Mark W. Ledeboer, Thomas Hoock, MichaelJ. Arnost, Randy S. Bethiel, Youssef L. Bennani, James J. Black, Christopher L. Brummel, Ananthsrinivas Chakilam, Warren A. Dorsch, Bin Fan, JohnE. Cochran, Summer Halas, Edmund M. Harrington, JamesK. Hogan, David Howe, Hui Huang, DylanH. Jacobs, Leena M. Laitinen, Shengkai Liao
Publikováno v:
Journal of Medicinal Chemistry; Sep2015, Vol. 58 Issue 18, p7195-7216, 22p