Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Randy S Longman"'
Autor:
Jose U Scher, Andrew Sczesnak, Randy S Longman, Nicola Segata, Carles Ubeda, Craig Bielski, Tim Rostron, Vincenzo Cerundolo, Eric G Pamer, Steven B Abramson, Curtis Huttenhower, Dan R Littman
Publikováno v:
eLife, Vol 2 (2013)
Rheumatoid arthritis (RA) is a prevalent systemic autoimmune disease, caused by a combination of genetic and environmental factors. Animal models suggest a role for intestinal bacteria in supporting the systemic immune response required for joint inf
Externí odkaz:
https://doaj.org/article/4ff853344f7f429ba805020254f4914b
Autor:
Nguyen T. Van, Karen Zhang, Rachel M. Wigmore, Anne I. Kennedy, Carolina R. DaSilva, Jialing Huang, Manju Ambelil, Jose H. Villagomez, Gerald J. O’Connor, Randy S. Longman, Miao Cao, Adam E. Snook, Michael Platten, Gerard Kasenty, Luis J. Sigal, George C. Prendergast, Sangwon V. Kim
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Environmental factors are the major contributor to the onset of immunological disorders such as ulcerative colitis. However, their identities remain unclear. Here, we discover that the amount of consumed L-Tryptophan (L-Trp), a ubiquitous di
Externí odkaz:
https://doaj.org/article/ec2a535921bc46a180d596010b048d5b
Autor:
Andrea A. Hill, Myunghoo Kim, Daniel F. Zegarra-Ruiz, Lin-Chun Chang, Kendra Norwood, Adrien Assié, Wan-Jung H. Wu, Michael C. Renfroe, Hyo Wong Song, Angela M. Major, Buck S. Samuel, Joseph M. Hyser, Randy S. Longman, Gretchen E. Diehl
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
Chronic exposure to high-fat diets (HFD) worsens intestinal disease pathology, but acute effects of HFD in tissue damage remain unclear. Here, we used short-term HFD feeding in a model of intestinal injury and found sustained damage with increased ce
Externí odkaz:
https://doaj.org/article/4dbaf7f237bf47bcb811593b4ac7bcb2
Autor:
Jim G. Castellanos, Randy S. Longman
Publikováno v:
Gut Microbes, Vol 11, Iss 2, Pp 231-236 (2020)
Despite continuous exposure to trillions of microbes, the intestinal immune system protects the mucosa by balancing barrier protection, tolerance, and immunity. As both sentinel and effector, the mucosal innate immune system plays a central role in c
Externí odkaz:
https://doaj.org/article/92f56c7b3d664f6e90948e586c646baf
Autor:
Robert, Battat, Ellen J, Scherl, Dana, Lukin, Paris, Charilaou, Prerna, Mahtani, Juliette, Gerber, Jorge A, Gandara, Friederike, Dündar, Paul, Zumbo, Doron, Betel, Chun-Jun, Guo, Randy S, Longman
Publikováno v:
Journal of Crohn's and Colitis. 17:795-803
Background Most Crohn’s disease [CD] patients require surgery. Ileitis recurs after most ileocolectomies and is a critical determinant for outcomes. The impacts of ileocolectomy-induced bile acid [BA] perturbations on intestinal microbiota and infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d964158a4fc8bfc2916806072d1712
https://doi.org/10.1093/ecco-jcc/jjac173
https://doi.org/10.1093/ecco-jcc/jjac173
Autor:
Donggi Paik, Lina Yao, Yancong Zhang, Sena Bae, Gabriel D. D’Agostino, Minghao Zhang, Eunha Kim, Eric A. Franzosa, Julian Avila-Pacheco, Jordan E. Bisanz, Christopher K. Rakowski, Hera Vlamakis, Ramnik J. Xavier, Peter J. Turnbaugh, Randy S. Longman, Michael R. Krout, Clary B. Clish, Fraydoon Rastinejad, Curtis Huttenhower, Jun R. Huh, A. Sloan Devlin
Publikováno v:
Nature
The microbiota modulates gut immune homeostasis. Bacteria influence the development and function of host immune cells, including T helper cells expressing interleukin-17A (T(H)17 cells). We previously reported that the bile acid (BA) metabolite 3-oxo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16eddc62eb60517d72fb52715e288086
https://doi.org/10.1038/s41586-022-04480-z
https://doi.org/10.1038/s41586-022-04480-z
Autor:
Dana J. Lukin, Paul J. Christos, Robert Battat, Waseem Ahmed, Jonathan S. Galati, Ellen Scherl, Anand Kumar, Randy S. Longman
Publikováno v:
Clinical Gastroenterology and Hepatology. 20:e361-e379
Background and Aims We conducted a systematic review and meta-analysis to summarize emerging data on the safety and effectiveness of dual biologic therapy in combination or with tofacitinib in patients with refractory inflammatory bowel disease (IBD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c339d5ab96b721bdd49a9ab378161ef
https://doi.org/10.1016/j.cgh.2021.03.034
https://doi.org/10.1016/j.cgh.2021.03.034
Autor:
John Hambor, Lance Chou, Randy S. Longman, Monica Viladomiu, Wen-Bing Jin, Svetlana Lima, Su-Ellen Brown, Chun-Jun Guo, Vinita Jacob, Silvia Pires, Ylaine Gerardin, Gregory G. Putzel, Carl V. Crawford, Ellen Scherl, Lasha Gogokhia
Publikováno v:
Gastroenterology
Background & Aims Fecal microbiota transplantation (FMT) is an emerging treatment modality for ulcerative colitis (UC). Several randomized controlled trials have shown efficacy for FMT in the treatment of UC, but a better understanding of the transfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32fe7de9853f81541a1a9a714e9c448
https://doi.org/10.1053/j.gastro.2021.09.061
https://doi.org/10.1053/j.gastro.2021.09.061
Autor:
William D. Fiers, Jesús Pla, Randy S. Longman, Woan-Yu Lin, Irina Leonardi, Patrick C Wilson, Iliyan D. Iliev, Meghan Bialt-DeCelie, Itai Doron, Xin Li, Dustin G. Shaw, Takato Kusakabe, Elvira Román, Marissa Mesko
Publikováno v:
Nature Microbiology. 6:1493-1504
Secretory immunoglobulin A (sIgA) plays an important role in gut barrier protection by shaping the resident microbiota community, restricting the growth of bacterial pathogens and enhancing host protective immunity via immunological exclusion. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e8b38ce8f7c82c5865965a9713b4cb4
https://doi.org/10.1038/s41564-021-00983-z
https://doi.org/10.1038/s41564-021-00983-z
Autor:
Andrea A. Hill, Myunghoo Kim, Daniel F. Zegarra-Ruiz, Lin-Chun Chang, Kendra Norwood, Adrien Assié, Wan-Jung H. Wu, Michael C. Renfroe, Hyo Wong Song, Angela M. Major, Buck S. Samuel, Joseph M. Hyser, Randy S. Longman, Gretchen E. Diehl
Publikováno v:
JCI insight.
Chronic exposure to high-fat diets (HFD) worsens intestinal disease pathology, but acute effects of HFD in tissue damage remain unclear. Here, we used short-term HFD feeding in a model of intestinal injury and found sustained damage with increased ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1a61b87f0b50f66cccc537b3ba7e22
https://pubmed.ncbi.nlm.nih.gov/36538527
https://pubmed.ncbi.nlm.nih.gov/36538527