Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Randy Ramharack"'
Autor:
Randy Ramharack, Peggy Liao, Janak Khimchand Padia, Bruce D. Roth, Patt William Chester, Helen Tsenwhei Lee, Mark A Spahr, Jason K. Pontrello, Karen Elaine Sexton, Mark A. Massa
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:4827-4845
Compounds of the general structure A and B were investigated for their activity as lipoprotein(a), [Lp(a)], assembly (coupling) inhibitors. SAR around the amino acid derivatives (structure A) gave compound 14-6 as a potent coupling inhibitor. Oral do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8eb8e08ad1868ff21ba683a1dd33e9
https://doi.org/10.1016/j.bmc.2002.04.001
https://doi.org/10.1016/j.bmc.2002.04.001
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1438:322-328
Lipoprotein (a) [Lp(a)] is a heterodimer of apolipoprotein (a) [apo(a)] and apolipoprotein B-100 (apoB-100) of low density lipoprotein linked by a disulfide bond. Apo(a) and apoB-100 are synthesized by the liver and covalently associate or couple to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022a0217fd6cfc6a7240154152315966
https://doi.org/10.1016/s1388-1981(99)00065-7
https://doi.org/10.1016/s1388-1981(99)00065-7
Autor:
Mark A. Spahr, William T. Mueller, Randy Ramharack, Fu-Zon Chung, Lan-Hsin Wu, Ye Tian, Dale L. Oxender, Helen T. Lee, Philip D. Settimi, Scott R. Eaton
Publikováno v:
Protein Expression and Purification. 13:222-228
Elevated plasma lipoprotein(a) [Lp(a)] is an independent risk factor for several vascular diseases. Lp(a) particles are generated through the formation of a disulfide bond between Cys 4057 of kringle IV type 9, (KIVt9), of the multikringle apolipopro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4255e947ef827422e853f6615e7def55
https://doi.org/10.1006/prep.1998.0898
https://doi.org/10.1006/prep.1998.0898
Autor:
Brian K Krause, Mark A. Spahr, Randy Ramharack, Helen T. Lee, R. F. Bousley, Catherine S. Sekerke, R. L. Stanfield
Publikováno v:
Atherosclerosis. 136:79-87
Lipoprotein(a) (Lp(a)), which is generated through the covalent association of apolipoprotein(a) (apo(a)) and apo B-100-LDL, is an independent risk factor for several vascular diseases. Therefore, there is interest in developing therapies for lowerin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c01a16b8e190e230c9a16bfc90ea3d
https://doi.org/10.1016/s0021-9150(97)00189-5
https://doi.org/10.1016/s0021-9150(97)00189-5
Publikováno v:
Biochemical and Biophysical Research Communications. 238:48-52
Elevated plasma lipoprotein(a) [Lp(a)] independently contributes to a variety of vascular diseases; consequentially, factors that modulate its levels are of interest. Since Lp(a) is produced by a disulfide linkage between apolipoprotein(a) [apo(a)] a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa3d9bf3e681ef5d39366d84d7f570f
https://doi.org/10.1006/bbrc.1997.7240
https://doi.org/10.1006/bbrc.1997.7240
Publikováno v:
Journal of Lipid Research, Vol 37, Iss 9, Pp 2029-2040 (1996)
The apolipoprotein[a] (apo[a]) and plasminogen (PLG) genes share a high degree of sequence identity, suggesting that both genes may be coordinately expressed. To address this possibility, hepatic apo[a], PLG, and glyceraldehyde-3-phosphate dehydrogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8e0fac6c9183a8c19a6186433e06dc
http://www.sciencedirect.com/science/article/pii/S0022227520375672
http://www.sciencedirect.com/science/article/pii/S0022227520375672
Autor:
Marlys L. Koschinsky, Randy Ramharack
Publikováno v:
Current Pharmaceutical Design. 2:121-138
Abstract: Lipoprotein(a) (Lp(a)) is a focus of intensive investigation owing to the correlation that has been demonstrated between elevated plasma Lp(a) levels and the development of a variety of atherosclerotic disorders. The Lp(a) particle resemble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb7a9a18841d8fe50b45f52f38b3b0bd
https://doi.org/10.2174/1381612802666220920220623
https://doi.org/10.2174/1381612802666220920220623
Autor:
Roger S. Newton, David W. Brammer, Mark A. Spahr, Gary W. Hicks, Randy Ramharack, Laura L. Minton, K.A. Kieft
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 6, Pp 1294-1304 (1995)
Eight male cynomolgus monkeys (Macaca fascicularis) on a normal chow diet were orally administered gemfibrozil daily using a weekly rising dose protocol for 3 weeks (50, 125, and 200 mg/kg per day). At these drug doses, Lp[a] levels were reduced: 83.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fe64ddd58c8a3beedbec2ccaada1d2
https://doi.org/10.1016/s0022-2275(20)41137-x
https://doi.org/10.1016/s0022-2275(20)41137-x
Autor:
Shui-Pang Tam, Randy Ramharack
Publikováno v:
Atherosclerosis. 95:137-146
The human hepatoma cell line, HepG2, was cultured with 25 OH cholesterol, a potent inhibitor of HMG-CoA reductase, in order to examine the effect of the oxysterol on apo E synthesis and secretion. Treatment of cells with oxysterol (2.5 microM) result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79dd3843b73796091f6e73868927d7f
https://doi.org/10.1016/0021-9150(92)90017-b
https://doi.org/10.1016/0021-9150(92)90017-b
Publikováno v:
Journal of Biological Chemistry. 266:16764-16773
We have carried out parallel analyses of the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGr) and low density lipoprotein receptor (LDLr) in two highly differentiated human hepatoma cell lines, HepG2 and Hep3B, and primary culture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2271c77592ee9a44829236201fb4468
https://doi.org/10.1016/s0021-9258(18)55366-7
https://doi.org/10.1016/s0021-9258(18)55366-7