Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Randy R, Miller"'
Autor:
Brian M. Maas, Julie Strizki, Randy R. Miller, Sushma Kumar, Michelle Brown, Matthew G. Johnson, Mickie Cheng, Carisa De Anda, Matthew L. Rizk, Julie A. Stone
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 2, Pp n/a-n/a (2024)
Abstract Molnupiravir is an oral prodrug of the broadly active, antiviral ribonucleoside analog N‐hydroxycytidine (NHC). The primary circulating metabolite NHC is taken up into cells and phosphorylated to NHC‐triphosphate (NHC‐TP). NHC‐TP ser
Externí odkaz:
https://doaj.org/article/80235adabbc14c2b94f7c558ebb6cf63
Autor:
Carl H. Backes, Jennifer L. Notestine, Jane M. Lamp, Jeanne C. Balough, Allison M. Notestine, Crystal M. Alfred, Juli M. Kern, Michael R. Stenger, Brian K. Rivera, Mohannad Moallem, Randy R. Miller, Apurwa Naik, Jennifer N. Cooper, Christopher R. Howard, Stephen E. Welty, Noah H. Hillman, John A. F. Zupancic, Larissa I. Stanberry, Thomas N. Hansen, Charles V. Smith
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background At birth, the majority of neonates born at
Externí odkaz:
https://doaj.org/article/01fe42366e3042398ec198fd1354ea91
Autor:
Abdeldjalil Madani, Dereje A. Negatu, Abdellatif El Marrouni, Randy R. Miller, Christopher Boyce, Nicholas Murgolo, Christopher J. Bungard, Matthew D. Zimmerman, Véronique Dartois, Martin Gengenbacher, David B. Olsen, Thomas Dick
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
Tricyclic pyrrolopyrimidines (TPPs) are a new class of antibacterials inhibiting the ATPase of DNA gyrase. TPP8, a representative of this class, is active against Mycobacterium abscessus in vitro. Spontaneous TPP8 resistance mutations mapped to the A
Autor:
Matthew L. Rizk, Paul van den Berg, Maurice J. Ahsman, Teun M. Post, Leticia Arrington, Filippos Kesisoglou, Wei Gao, Randy R. Miller
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 7, Pp 658-670 (2021)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
Uprifosbuvir is a uridine nucleoside monophosphate prodrug inhibitor of the hepatitis C virus NS5B RNA polymerase. To quantitatively elucidate key metabolic pathways, assess the link between unmeasurable effect site concentrations and viral load redu
Autor:
Sam V Machotka, Frank D. Sistare, Amy G. Aslamkhan, Alex M Tamburino, Todd Pippert, Raymond Evers, Kaushik Mitra, Keith Q. Tanis, Timothy E. Johnson, Donna Lynch, Wen Kang, Truyen Nguyen, Randy R. Miller, James J Monroe, Tamara D. Cabalu, Alexei A. Podtelezhnikov, Nancy G. B. Agrawal, Jairam Palamanda
Publikováno v:
Toxicological Sciences
Drug-induced liver injury is a major reason for drug candidate attrition from development, denied commercialization, market withdrawal, and restricted prescribing of pharmaceuticals. The metabolic bioactivation of drugs to chemically reactive metabol
Autor:
Michael R. Stenger, Thomas N. Hansen, C Peter Richardson, Mohannad Moallem, Stephen E. Welty, Randy R. Miller, Laura Marzec, Larissa Stanberry, Lindsey J. Beer, Crystal M Alfred, Charles V. Smith, Christopher R A Howard, Jennifer N. Cooper, Brian K. Rivera, Molly K. Ball, Jennifer L. Notestine, Apurwa Naik, Carl H. Backes, Jane M. Lamp, Noah H. Hillman, John A.F. Zupancic
Publikováno v:
Journal of Perinatology
Objective To test the hypothesis that infants born Study design Randomized trial (3/2017-01/2019) at 5 NICUs. The primary outcome was CPAP failure; subgroup analyses (gestational age, receipt antenatal corticosteroids) were performed. Results A total
Autor:
Jeanne C. Balough, Stephen E. Welty, Thomas N. Hansen, Mohannad Moallem, Crystal M Alfred, Charles V. Smith, Randy R. Miller, Michael R. Stenger, Brian K. Rivera, Larissa Stanberry, Allison M. Notestine, Jennifer N. Cooper, Christopher R A Howard, Carl H. Backes, Jennifer L. Notestine, Apurwa Naik, John A.F. Zupancic, Juli M. Kern, Jane M. Lamp, Noah H. Hillman
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-10 (2019)
Trials
Trials
Background: At birth, the majority of neonates born at Methods: We designed a multicenter, non-blinded, randomized controlled trial that will enroll 230 premature infants (220/7 to 296/7 weeks of gestation). Infants will be randomized to receive Seat
Autor:
Harold B. Wood, Maria Madeira, Wayne M. Geissler, Conrad E. Raab, Randy R. Miller, Iain Martin
Publikováno v:
Journal of medicinal chemistry. 63(21)
Lipophilicity has a dominant effect on many parameters that determine unbound drug exposure as well as drug potency. Despite this, analysis of a large body of drug data indicates lipophilicity has no consistent directional impact on dose. This can be
Autor:
Hiroshi Nagabukuro, Sean M. Smith, Richard A. Berger, Melissa Costa, Nam Fung Kar, Bart Harper, Karen H. Dingley, Gino Salituro, Liping Wang, Jerry Di Salvo, Scott D. Edmondson, Bing Li, Xiaofang Li, Cheng Zhu, Christopher Moyes, Stephen D. Goble, Sookhee Ha, Mary Struthers, Jeffrey J. Hale, Amanda L. Hurley, Randy R. Miller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1094-1098
The synthesis of a novel class of piperazine benzamide (reverse amides) targeting the human β3-adrenergic receptor for the treatment of overactive bladder (OAB) is described. The SAR studies directed towards maintaining well established β3 potency
Autor:
Carl H. Backes, RNC-NIC BSN Jennifer L. Notestine, RN-BC MS Jane M. Lamp, IBCLC FACCE RN MSN Jeanne C. Balough, Allison M. Notestine, RRT MS Crystal M. Alfred, Juli M. Kern, Michael R. Stenger, MS Brian K. Rivera, Mohannad Moallem, Randy R. Miller, Apurwa Naik, Jennifer N. Cooper, MBA Christopher R. Howard, Stephen E. Welty, Noah H. Hillman, John A. F. Zupancic, Larissa I. Stanberry, Thomas N. Hansen, Charles V. Smith
Background: At birth, the majority of neonates born at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::766a6da684efd3b92cd3ea459b0866ec
https://doi.org/10.21203/rs.1.18/v1
https://doi.org/10.21203/rs.1.18/v1