Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Randy Przybylla"'
Autor:
Randy Przybylla, Mathias Krohn, Marie-Luise Sellin, Marcus Frank, Stefan Oswald, Michael Linnebacher
Publikováno v:
Cells, Vol 12, Iss 19, p 2371 (2023)
The most common in vitro model for absorption, distribution, metabolism, and excretion (ADME) purposes is currently the Caco-2 cell line. However, clear differences in gene and protein expression towards the small intestine and an, at best, fair pred
Externí odkaz:
https://doaj.org/article/0cbd71dd3bbe415492a26b961788496e
Autor:
Randy Przybylla, Christina Susanne Mullins, Mathias Krohn, Stefan Oswald, Michael Linnebacher
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9861 (2022)
Commonly used intestinal in vitro models are limited in their potential to predict oral drug absorption. They either lack the capability to form a tight cellular monolayer mimicking the intestinal epithelial barrier or the expression of cytochrome P4
Externí odkaz:
https://doaj.org/article/8ef2d85fcf5c4fe4946499059fe98caf
Autor:
Lili Lu, Randy Przybylla, Yuru Shang, Meng Dai, Mathias Krohn, Oliver Holger Krämer, Christina Susanne Mullins, Michael Linnebacher
Publikováno v:
Cancers, Vol 14, Iss 4, p 1032 (2022)
Clinical utilization of curcumin in colorectal cancer (CRC) was revived as a result of the development of novel curcumin formulations with improved bioavailability. Additionally, identification of biomarkers for curcumin sensitivity would also promot
Externí odkaz:
https://doaj.org/article/c6e0f9f5b6c348d1851b6fc7081cbf19
Autor:
Sandra Wagner, Nicola T. Beger, Stephanie Matschos, Antonia Szymanski, Randy Przybylla, Florian Bürtin, Friedrich Prall, Michael Linnebacher, Christina S. Mullins
Publikováno v:
Cancers, Vol 13, Iss 18, p 4717 (2021)
The prognosis of metastatic colorectal cancer (CRC) remains poor. Patients and physicians are in need of individual therapies and precise response predictions. We investigated the predictive capacity of primary tumour material for treatment response
Externí odkaz:
https://doaj.org/article/fd73d95510414184b3e86b255a625947
Autor:
Lili Lu, Randy Przybylla, Yuru Shang, Meng Dai, Mathias Krohn, Oliver Holger Krämer, Christina Susanne Mullins, Michael Linnebacher
Publikováno v:
Cancers; Volume 14; Issue 4; Pages: 1032
Clinical utilization of curcumin in colorectal cancer (CRC) was revived as a result of the development of novel curcumin formulations with improved bioavailability. Additionally, identification of biomarkers for curcumin sensitivity would also promot
Autor:
Friedrich Prall, Stephanie Matschos, Florian Bürtin, Michael Linnebacher, Antonia Szymanski, Randy Przybylla, Sandra Wagner, Christina S Mullins, Nicola T. Beger
Publikováno v:
Cancers
Volume 13
Issue 18
Cancers, Vol 13, Iss 4717, p 4717 (2021)
Volume 13
Issue 18
Cancers, Vol 13, Iss 4717, p 4717 (2021)
Simple Summary Colorectal cancer is a global issue with millions of patients in need for new treatment options. Surgical resection is often the first clinical intervention and can be, especially for primary tumours, curative. However, advanced tumour