Genetic mechanism of human neutrophil antigen 2 deficiency and expression variations.

Autor: Yunfang Li, David C Mair, Randy M Schuller, Ling Li, Jianming Wu

Publikováno v: PLoS Genetics, Vol 11, Iss 5, p e1005255 (2015)

Human neutrophil antigen 2 (HNA-2) deficiency is a common phenotype as 3-5% humans do not express HNA-2. HNA-2 is coded by CD177 gene that associates with human myeloproliferative disorders. HNA-2 deficient individuals are prone to produce HNA-2 allo

Externí odkaz: https://doaj.org/article/586497cea169486f9bdfd0ba833ec8fe

The nonconservativeCD177single‐nucleotide polymorphism c.1291G>A is a genetic determinant for human neutrophil antigen‐2 atypical/low expression and deficiency

Autor: Behnaz Bayat, Randy M. Schuller, Anne Sophie Litmeyer, Yunfang Li, Jianming Wu, Ling Li, Gregor Bein, Ulrich J. Sachs

Publikováno v: Transfusion. 59:1836-1842

Background Human neutrophil antigen-2 (HNA-2) is exclusively expressed on neutrophils. HNA-2-deficient individuals (HNA-2 null) are susceptible to produce isoantibodies. The nonsense CD177 coding single-nucleotide polymorphism (SNP) c.787A>T has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9eee0029f90f0fb627b30976927700d9
https://doi.org/10.1111/trf.15222

Genetic mechanism of human neutrophil antigen 2 deficiency and expression variations

Autor: Ling Li, Jianming Wu, Yunfang Li, Randy M. Schuller, David C. Mair

Publikováno v: PLoS Genetics, Vol 11, Iss 5, p e1005255 (2015)
PLoS Genetics

Human neutrophil antigen 2 (HNA-2) deficiency is a common phenotype as 3–5% humans do not express HNA-2. HNA-2 is coded by CD177 gene that associates with human myeloproliferative disorders. HNA-2 deficient individuals are prone to produce HNA-2 al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421acb01f1c47e871d6bc479e4647ef9
http://europepmc.org/articles/PMC4449163?pdf=render

CD177 polymorphisms: correlation between high-frequency single nucleotide polymorphisms and neutrophil surface protein expression

Autor: Lorraine Caruccio, Kelly Walkovich, David F. Stroncek, Randy M. Schuller, Maria P. Bettinotti

Publikováno v: Transfusion. 44:77-82

BACKGROUND: Human neutrophil antigen-2a (NB1) is located on NB1 glycoprotein, which is expressed on subpopulations of neutrophils. PRV-1 is a gene that is over-expressed in neutrophils from patients with polycythemia rubra vera. The gene encoding NB1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::315acdaebe01a6e8c2efb98dea158348
https://doi.org/10.1046/j.0041-1132.2004.00606.x

Transfusion-related acute lung injury: incidence and risk factors

Autor: Rolf D. Hubmayr, Edward L. Murphy, Manish J. Gandhi, Ognjen Gajic, Philip J. Norris, Gregory A. Wilson, David C. Mair, Michael A. Gropper, Ping Wu, Mark R. Looney, Monique Koenigsberg, Barbara Grimes, Peter Bacchetti, Richard B. Weiskopf, Rosa Sanchez Rosen, Pearl Toy, Michael A. Matthay, Nora V. Hirschler, Deanna C. Lee, Clifford A. Lowell, Jeffrey L. Winters, Randy M. Schuller

Publikováno v: Toy, P; Gajic, O; Bacchetti, P; Looney, MR; Gropper, MA; Hubmayr, R; et al.(2012). Transfusion-related acute lung injury: Incidence and risk factors. Blood, 119(7), 1757-1767. doi: 10.1182/blood-2011-08-370932. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0nf7j145

Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality. To determine TRALI incidence by prospective, active surveillance and to identify risk factors by a case-control study, 2 academic medical centers enr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a7e9e414d8a5a44233fd7b190391a9
https://pubmed.ncbi.nlm.nih.gov/22343662