Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Randy Longman"'
Autor:
Anna-Maria Liebhoff, Thiagarajan Venkataraman, William R. Morgenlander, Miso Na, Tomasz Kula, Kathleen Waugh, Charles Morrison, Marian Rewers, Randy Longman, June Round, Stephen Elledge, Ingo Ruczinski, Ben Langmead, H. Benjamin Larman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract We investigate a relatively underexplored component of the gut-immune axis by profiling the antibody response to gut phages using Phage Immunoprecipitation Sequencing (PhIP-Seq). To cover large antigenic spaces, we develop Dolphyn, a method
Externí odkaz:
https://doaj.org/article/f671256a5dbb468ba920e54a8c3dd8ac
Autor:
Padma P. Nanaware, Zohaib N. Khan, Cristina C. Clement, Madhur Shetty, Ines Mota, Ethan S. Seltzer, Monika Dzieciatkowska, Fabia Gamboni, Angelo D’Alessandro, Charles Ng, Manabu Nagayama, Cheryl F. Lichti, Rajesh K. Soni, Jacob B. Geri, Irina Matei, David Lyden, Randy Longman, Theresa T. Lu, Xiaoxiao Wan, Emil R. Unanue, Lawrence J. Stern, Laura Santambrogio
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114311- (2024)
Summary: The lymphatic fluid is the conduit by which part of the tissue “omics” is transported to the draining lymph node for immunosurveillance. Following cannulation of the pre-nodal cervical and mesenteric afferent lymphatics, herein we invest
Externí odkaz:
https://doaj.org/article/957cfb99c70846f691804304c5c2963b
Autor:
Omary Mzava, Alexandre Pellan Cheng, Adrienne Chang, Sami Smalling, Liz-Audrey Kounatse Djomnang, Joan Sesing Lenz, Randy Longman, Amy Steadman, Luis G. Gómez-Escobar, Edward J. Schenck, Mirella Salvatore, Michael J. Satlin, Manikkam Suthanthiran, John R. Lee, Christopher E. Mason, Darshana Dadhania, Iwijn De Vlaminck
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The accuracy of metagenomic DNA sequencing is limited by environmental DNA contamination. Here, the authors develop and test SIFT-seq, a metagenomic DNA sequencing assay that allows to identify and remove environmental DNA contamination introduced du
Externí odkaz:
https://doaj.org/article/058d6e9e5ad3482da887a2928dfc0a0a
Autor:
Rochelle Wong, Lihui Qin, Yushan Pan, Prerna Mahtani, Randy Longman, Dana Lukin, Ellen Scherl, Robert Battat
Publikováno v:
Journal of Clinical Medicine, Vol 12, Iss 21, p 6796 (2023)
(1) Many patients with inflammatory bowel disease (IBD) in endoscopic remission have persistent histologic activity, which is associated with worse outcomes. There are limited data on the association between adalimumab drug concentrations and histolo
Externí odkaz:
https://doaj.org/article/b92c2484d5b04867be5b4ae79cc5552b
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Extracellular matrix (ECM) remodeling has emerged as a key feature of inflammatory bowel disease (IBD), and ECM fragments have been proposed as markers of clinical disease severity. Recent studies report increased protease activity in the gu
Externí odkaz:
https://doaj.org/article/63f251a66b9c4c39b54e1a5209bfd9c1
Autor:
Shiying Zhang, Xochitl Morgan, Belgin Dogan, Francois-Pierre Martin, Suzy Strickler, Akihiko Oka, Jeremy Herzog, Bo Liu, Scot E. Dowd, Curtis Huttenhower, Matthieu Pichaud, Esra I. Dogan, Jack Satsangi, Randy Longman, Rhonda Yantiss, Lukas A. Mueller, Ellen J. Scherl, R. Balfour Sartor, Kenneth W. Simpson
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Elucidating how resident enteric bacteria interact with their hosts to promote health or inflammation is of central importance to diarrheal and inflammatory bowel diseases across species. Here, we integrated the microbial and chemical microenvironmen
Externí odkaz:
https://doaj.org/article/c219403c4675442ebf44840ba6e8292c
Autor:
Anjana Rajan, Yushan Pan, Prerna Mahtani, Rachel Niec, Randy Longman, Juliette Gerber, Dana Lukin, Ellen Scherl, Robert Battat
Publikováno v:
Crohn's & Colitis 360. 5
Background Discordances between clinical and endoscopic Crohn’s disease (CD) activity indices negatively impact the utility of clinic visits and efficacy assessments in clinical trials. Bile acid diarrhea (BAD) and small intestinal bacterial overgr
Autor:
Yushan Pan, Waseem Ahmed, Prerna Mahtani, Rochelle Wong, Randy Longman, Dana Jeremy Lukin, Ellen J Scherl, Robert Battat
Publikováno v:
Inflammatory Bowel Diseases. 28:1865-1871
Background In postoperative Crohn’s disease (POCD), data are lacking on relationships between serum biologic concentrations and treatment outcomes. We assessed if established threshold concentrations of infliximab (IFX), adalimumab (ADA), and ustek
Autor:
Kaylie Chen, Johnson Chen, Emily Smith, Prerna Mathani, Randy Longman, Dana Lukin, Ellen Scherl, Juliette Gerber, Robert Battat
Publikováno v:
Inflammatory bowel diseases.
Lay Summary Higher ustekinumab concentrations were associated with improved radiologic (Simplified Magnetic Resonance Index of Activity for Crohn’s Disease) and stringent biomarker (calprotectin) outcomes. The high concentration needed for these no
Autor:
Svetlana Lima, Amanda Rupert, Wenbing Jin, Monica Viladomiu, Silvia Pires, Viola Woo, Gregory Putzel, Andrew Marderstein, Gabriela Funez-dePagnier1, Wei Yang, Chun-Jun Guo, Ellen Scherl, Randy Longman
Publikováno v:
Gastroenterology. 164:S93
Joint inflammation, or spondyloarthritis (SpA), is the most common extra-intestinal manifestation of inflammatory bowel disease (IBD), but the specific role for therapies targeting SpA is not well defined. One of the earliest medications used for the