Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Randy L. Smith"'
Autor:
Jerri M. Rook, Carrie K. Jones, Jeffrey Kedrowski, Randy L. Smith, P. Jeffrey Conn, Craig W. Lindsley, Alice L. Rodriguez, Sameer Sharma
Publikováno v:
Journal of Medicinal Chemistry. 52:4103-4106
We describe the synthesis and SAR of a series of analogues of the mGlu5 partial antagonist 5-(phenylethynyl)pyrimidine. New molecular switches are identified that modulate the pharmacological activity of the lead compound. Slight structural modificat
Publikováno v:
Neuropharmacology. 52:1671-1677
Extensive evidence suggests that 5-HT2 receptors may play a role in mental disorders including schizophrenia. In addition, several studies indicate that G(q)-coupled 5-HT(2A) receptors are likely targets for the initiation of events leading to the ha
Publikováno v:
Neuropsychopharmacology. 30:1693-1702
Tolerance is defined as a decrease in responsiveness to a drug after repeated administration. Tolerance to the behavioral effects of hallucinogens occurs in humans and animals. In this study, we used drug discrimination to establish a behavioral mode
Publikováno v:
Psychopharmacology. 179:854-862
The drug discrimination procedure is the most frequently used in vivo model of hallucinogen activity. Historically, most drug discrimination studies have been conducted in the rat. With the development of genetically modified mice, a powerful new too
Autor:
Craig H. Kennedy, Randy L. Smith, Tina G. Patterson, Celeste Roberts, Michael E. May, Mary Caruso, Mark T. Harvey, Maria G. Valdovinos
Publikováno v:
Psychopharmacology. 176:123-128
REM sleep deprivation (REMSD) has been shown to increase rates of free-operant avoidance responding. Depletion of 5-hydroxytryptamine (5-HT, serotonin) levels produces similar effects on responding. We studied whether the pharmacological activation o
Publikováno v:
Psychopharmacology. 166:61-68
Rationale. The drug discrimination procedure has proven to be a valuable tool for studying the mechanism of action of psychoactive drugs. Recently, mice with targeted gene mutations have been developed that may also prove useful in evaluating the rol
Publikováno v:
Pharmacology Biochemistry and Behavior. 72:77-85
The purpose of this study was to determine if animals trained to discriminate a serotonin 2A (5-HT 2A ) receptor agonist from a 5-HT 2A receptor antagonist would also be sensitive to alterations in serotonin neurotransmission brought about by 5-HT re
Publikováno v:
Psychopharmacology. 144:248-254
Rationale: Defining the mechanism of tolerance development to hallucinogenic drugs will help to explain their mechanism of action. Objectives: The present study was conducted to determine first, if tolerance develops to the discriminative stimulus (D
Publikováno v:
Pharmacology Biochemistry and Behavior. 61:323-330
R. L. SMITH, H. CANTON, R. J. BARRETT AND E. SANDERS-BUSH. Agonist properties of N,N-Dimethyltryptamine at 5-HT2A and 5-HT2C receptors. PHARMACOL BIOCHEM BEHAV 61(3) 323–330, 1998.—Extensive behavioral and biochemical evidence suggests an agonist
Publikováno v:
Psychopharmacology. 113:351-360
The purpose of this study was to determine whether rats could be trained to discriminate the stimulus properties of the benzodiazepine (BZ) receptor inverse agonist DMCM from saline in a conditioned taste aversion paradigm. On a drug trial, water-dep