Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Randy L. Rose"'
Autor:
Randy L. Rose, Ernest Hodgson
Publikováno v:
Pest Management Science. 64:617-621
Agrochemicals and other xenobiotics are metabolized by xenobiotic-metabolizing enzymes (XMEs) to products that may be more or less toxic than the parent chemical. In this regard, phase-I XMEs such as cytochrome P450s (CYPs) are of primary importance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f8d8dc85cc25febf18863b11f4ce5f
https://doi.org/10.1002/ps.1563
https://doi.org/10.1002/ps.1563
Publikováno v:
Drug Metabolism and Drug Interactions. 23:237-260
Xenobiotics, including drugs and environmental chemicals, can influence cytochrome P450 (CYP) levels by altering the transcription of CYP genes. To minimize potential drug-pesticide and pesticide-pesticide interactions it is important to evaluate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383ade75f4278d64ae5e1eaf3d3dbbb9
https://doi.org/10.1515/dmdi.2008.23.3-4.237
https://doi.org/10.1515/dmdi.2008.23.3-4.237
Autor:
Ernest Hodgson, Randy L. Rose
Publikováno v:
Pharmacology & Therapeutics. 113:420-428
Cytochrome P450 (CYP) 2B6 (CYP2B6) is a human CYP isoform found in variable amounts in the liver and other organs. It is known to be inducible and polymorphic and has a wide range of xenobiotic substrates. Studies of CYP2B6 to date have concentrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d498063226d313e707f483cf51b9a6a7
https://doi.org/10.1016/j.pharmthera.2006.10.002
https://doi.org/10.1016/j.pharmthera.2006.10.002
Publikováno v:
Chemico-Biological Interactions. 164:200-214
Recent studies have demonstrated the potential of pesticides to either inhibit or induce xenobiotic metabolizing enzymes in humans. Exposure of human hepatocytes to doses of fipronil (5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluorome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b6149f3a5a7f6608c045981015583e
https://doi.org/10.1016/j.cbi.2006.09.013
https://doi.org/10.1016/j.cbi.2006.09.013
Publikováno v:
Drug Metabolism and Disposition. 34:1606-1614
Cytochromes P450 (P450s) are major catalysts in the metabolism of xenobiotics and endogenous substrates such as estradiol (E2). It has previously been shown that E2 is predominantly metabolized in humans by CYP1A2 and CYP3A4 with 2-hydroxyestradiol (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83ad8096fcd71133b922ca1bf849412
https://doi.org/10.1124/dmd.106.010439
https://doi.org/10.1124/dmd.106.010439
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 20:279-291
The metabolism of chlorpyrifos (CPS) and chlorpyrifos oxon (CPO) by human hepatocytes and human liver S9 fractions was investigated using LC-MS/MS. Cytochrome P450 (CYP)-dependent and phase II-related products were determined following incubation wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee8dc2b0ce75c5197a49f8de3b323f0
https://doi.org/10.1002/jbt.20145
https://doi.org/10.1002/jbt.20145
Publikováno v:
Drug Metabolism and Disposition. 34:176-183
The polycyclic aromatic hydrocarbon naphthalene is an environmental pollutant, a component of jet fuel, and, since 2000, has been reclassified as a potential human carcinogen. Few studies of the in vitro human metabolism of naphthalene are available,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0163a9c8bb79479279d7ee236c02ae
https://doi.org/10.1124/dmd.105.005785
https://doi.org/10.1124/dmd.105.005785
Publikováno v:
Chemico-Biological Interactions. 151:203-211
Nonane, a component of jet-propulsion fuel 8 (JP-8), is metabolized to 2-nonanol and 2-nonanone by pooled human liver microsomes (pHLM). Cytochrome P450 (CYP) isoforms 1A2, 2B6 and 2E1 metabolize nonane to 2-nonanol, whereas alcohol dehydrogenase, CY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9bf9c71824b48eb0261bc91554106e
https://doi.org/10.1016/j.cbi.2004.12.003
https://doi.org/10.1016/j.cbi.2004.12.003
Publikováno v:
Chemico-Biological Interactions. 147:319-329
Fipronil (5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile) is a highly active, broad spectrum insecticide from the phenyl pyrazole family, which targets the gamma-amino butyric acid (GABA) r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d8ed4b6e7712d6155f0a1dd42a7cb8
https://doi.org/10.1016/j.cbi.2004.03.002
https://doi.org/10.1016/j.cbi.2004.03.002
Publikováno v:
Pesticide Biochemistry and Physiology. 74:117-128
Permethrin is a pyrethroid insecticide widely used in agriculture and public health. It has been suggested that permethrin may interact with other chemicals used during military deployments and, as a result, be a potential cause of Gulf War Related I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40c29b1e8599220c1f4539075a5ae68d
https://doi.org/10.1016/s0048-3575(02)00154-2
https://doi.org/10.1016/s0048-3575(02)00154-2