Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Randy J. Thresher"'
Autor:
Derek J. Blake, Helen E. Gruber, Jeffrey Rosenfeld, Elizabeth Keramaris-Vrantsis, Jignya Ashar, Natalia Zinchenko, James Norton, Qi L. Lu, Hart G.W. Lidov, Randy J. Thresher, Yiumo Michael Chan
Publikováno v:
Human Molecular Genetics. 19:3995-4006
Mutations in fukutin-related protein (FKRP) cause a common subset of muscular dystrophies characterized by aberrant glycosylation of alpha-dystroglycan (α-DG), collectively known as dystroglycanopathies. The clinical variations associated with FKRP
Autor:
Jan Krzysztof Blusztajn, Steven H. Zeisel, Ya Wen Teng, Corneliu N. Craciunescu, Randy J. Thresher, Zhong Guo, Amy R. Johnson
Publikováno v:
The FASEB Journal. 24:2752-2761
Choline dehydrogenase (CHDH) cata- lyzes the conversion of choline to betaine, an important methyl donor and organic osmolyte. We have previ- ously identified single nucleotide polymorphisms (SNPs) in the human CHDH gene that, when present, seem to a
Autor:
Randy J. Thresher, Zhi Liu, George J. Giudice, Gang Ning, Wen Sui, Minglang Zhao, Zhuowei Li, Ning Li, Cassian Sitaru, Detlef Zillikens, Luis A. Diaz, Janet A. Fairley, M. Peter Marinkovich
Publikováno v:
Journal of Autoimmunity. 31:331-338
Bullous pemphigoid (BP) is a cutaneous autoimmune inflammatory disease associated with subepidermal blistering and autoantibodies against BP180, a transmembrane collagen and major component of the hemidesmosome. Numerous inflammatory cells infiltrate
Autor:
Michael G. O'Rand, William F. Marzluff, Eric J. Wagner, Gail Grossman, Oleg M. Alekseev, Kelly D. Sullivan, Randy J. Thresher, Esther E. Widgren, Richard T. Richardson
Publikováno v:
Journal of Biological Chemistry. 281:21526-21534
A multichaperone nucleosome-remodeling complex that contains the H1 linker histone chaperone nuclear autoantigenic sperm protein (NASP) has recently been described. Linker histones (H1) are required for the proper completion of normal development, an
Autor:
David S. Hsu, Yasuhide Miyamoto, Aziz Sancar, Martha Hotz Vitaterna, Joseph S. Takahashi, Claude Petit, Randy J. Thresher, Oliver Smithies, Aleksey Kazantsev, Christopher P. Selby, Lale Dawut
Publikováno v:
Science. 282:1490-1494
Cryptochromes are photoactive pigments in the eye that have been proposed to function as circadian photopigments. Mice lacking the cryptochrome 2 blue-light photoreceptor gene ( mCry2 ) were tested for circadian clock-related functions. The mutant mi
Autor:
Sharynn D. Hall, Alexander M. Makhov, Jack D. Griffith, Randy J. Thresher, Richard D. Kolodner
Publikováno v:
Journal of Molecular Biology. 254:364-371
Electron microscopy has been used to examine Escherichia coli RecT protein alone and in the complexes it forms with DNA substrates, with which it catalyzes strand exchange in vitro. Negative staining has revealed that the 33 kDa RecT protein monomers
Publikováno v:
The 2010 IEEE International Conference on Information and Automation.
Cell and embryo microinjections, like many other biomanipulation tasks, involve delicate and precise manual control of micropipettes under a microscope. These operations are repeatedly carried out by highly trained personnel, who spend hours peering
Publikováno v:
Journal of Molecular Biology. 226:425-432
Nucleotide excision repair in Escherichia coli is initiated by the UvrA, UvrB and UvrC proteins. UvrA is the damage recognition subunit, makes an A2B1 complex with the targeting subunit UvrB, and the complex binds to the lesion site; UvrA dissociates
Autor:
Heather A. Paich, Shuli Wang, Steven M. Watkins, Rosalind A. Coleman, Timothy R. Koves, George N. Altshuller, Deborah M. Muoio, Gary W. Cline, Gerald I. Shulman, Randy J. Thresher, Nan Gong, Lei O. Li, Jessica M. Ellis
Publikováno v:
The Journal of biological chemistry. 284(41)
In mammals, a family of five acyl-CoA synthetases (ACSLs), each the product of a separate gene, activates long chain fatty acids to form acyl-CoAs. Because the ACSL isoforms have overlapping preferences for fatty acid chain length and saturation and
Publikováno v:
IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society. 13(5)
Blastocyst microinjections are routinely involved in the process of creating genetically modified mice for biomedical research, but their efficiency is highly dependent on the skills of the operators. As a consequence, much time and resources are req