Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Randy H. Weiss"'
Autor:
Daryle H. Busch, William L. Neumann, Randy H. Weiss, Patrick L. Lennon, Dennis P. Riley, Delong Zhang
Publikováno v:
Inorganic Chemistry. 37:956-963
Iron(III) complexes with four pentaaza macrocylic ligands, [Fe(L)Cl2](PF6), have been synthesized, where the ligand L is 1,4,7,10,13-pentaazacyclopentadecane (L1), 2R,3R,8S,9S-dicyclohexano-1,4,7,10,13-pentaazacyclopentadecane (L2), 2R,3R,8R,9R -dicy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::963e93a9b3d5987c5da5d64541477f93
https://doi.org/10.1021/ic970861h
https://doi.org/10.1021/ic970861h
Publikováno v:
Journal of the American Chemical Society. 119:6522-6528
Two new isomeric bis(trans-fused cyclohexano) substituted 1,4,7,10,13-pentaazacyclopentadecane ligands and their Mn(II) complexes, 3 and 4, have been synthesized, and their activity as superoxide dismutase (SOD) catalysts has been studied. Complex 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6ef29779ed71bc33d44514927943e78
https://doi.org/10.1021/ja964271e
https://doi.org/10.1021/ja964271e
Synthesis of conformationally tailored pentaazacyclopentadecanes. Preorganizing peptide cyclizations
Autor:
William L. Neumann, Randy H. Weiss, Kirby R. Sample, Dennis P. Riley, Karl W. Aston, Gary W. Franklin
Publikováno v:
Tetrahedron Letters. 38:779-782
A general method for the preparation of rigidified pentaazamacrocycles using trans-(1R,2R)-diaminocyclohexane as the conformational controller element. High macrocyclization yields have been obtained by strategic placement of the diaminocyclohexane g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5bee4280fb1b6f28ffa0f28b55653f4
https://doi.org/10.1016/s0040-4039(96)02446-x
https://doi.org/10.1016/s0040-4039(96)02446-x
Publikováno v:
Journal of Biological Chemistry. 271:26149-26156
In a previous study (Hardy et al. (1994) J. Biol. Chem. 269, 18535-18540), we observed that the manganese-based superoxide dismutase mimetic Mn(II)-dichloro(1,4,7,10,13-pentaazacyclopentadecane) (MnPAM) inhibited neutrophil-mediated cell injury in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc78e7be828d874f8ce9b379d21641fd
https://doi.org/10.1074/jbc.271.42.26149
https://doi.org/10.1074/jbc.271.42.26149
Autor:
Randy H. Weiss, Kirby R. Sample, William L. Neumann, Witold Szulbinski, † Chaur-Sun Ling, Patrick J. Lennon, Dennis P. Riley, Willie J. Rivers, Jeng-Jong Shieh, Karl W. Aston, Hayat Rahman, and Daryle H. Busch, Susan L. Henke
Publikováno v:
Inorganic Chemistry. 35:5213-5231
Superoxide radical anion has been demonstrated to be a mediator of many disease states, including inflammatory, autoimmune, and cancerous diseases. As a consequence, we have developed a program to design, synthesize, and test synthetic low-molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::056ffc4cdfadf921ef7fe57c7355a58c
https://doi.org/10.1021/ic960262v
https://doi.org/10.1021/ic960262v
Publikováno v:
Journal of Biological Chemistry. 269:18535-18540
In this study, we evaluated the ability of low molecular weight manganese-based superoxide dismutase mimetics to attenuate neutrophil-mediated oxygen radical damage to human aortic endothelial cells in vitro. Human neutrophils, when exposed to tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daabaa7a0b9cac280f8209f557694aaf
https://doi.org/10.1016/s0021-9258(17)32342-6
https://doi.org/10.1016/s0021-9258(17)32342-6
Autor:
Susan L. Henke, William L. Neumann, Randy H. Weiss, Kirby R. Sample, Anil S. Modak, Karl W. Aston, Dennis P. Riley
Publikováno v:
Tetrahedron Letters. 35:3687-3690
A general synthetic method for the preparation of carbon-functionalized polyazamacrocycles from the corresponding cyclic peptides is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51ab00906bbdcb4a88b2ef0ae1c229f3
https://doi.org/10.1016/s0040-4039(00)73072-3
https://doi.org/10.1016/s0040-4039(00)73072-3
Autor:
Medora M. Hardy, Karl W. Aston, A. G. Flickinger, Una S. Ryan, Willie J. Rivers, Randy H. Weiss, Dennis P. Riley
Publikováno v:
Journal of Biological Chemistry. 268:23049-23054
By stopped-flow kinetic analysis, we have directly evaluated the superoxide dismutase (SOD) activity of a number of organic nitroxides and iron- and manganese-based complexes that have been attributed with having SOD activity based upon competition e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65a85cfc7d53fdc35e7b1c08626aa7a2
https://doi.org/10.1016/s0021-9258(19)49423-4
https://doi.org/10.1016/s0021-9258(19)49423-4
Autor:
Barry L. Parnas, Randy H. Weiss, Richard W. Gross, Stanley L. Hazen, Daniel P. Getman, Karl W. Aston, Patrick J. Lennon, Lori A. Zupan
Publikováno v:
Journal of Medicinal Chemistry. 36:95-100
Haloenol lactones are potent mechanism-based inhibitors of a novel class of calcium-independent phospholipases A2 which have been implicated as the enzymic mediators of membrane dysfunction during myocardial ischemia (Hazen, S. L.; et al. J. Biol. Ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e397d9026a25039dc79e818e404d01aa
https://doi.org/10.1021/jm00053a012
https://doi.org/10.1021/jm00053a012
Autor:
Nigam P. Rath, Karl W. Aston, Kirby R. Sample, William L. Neumann, Randy H. Weiss, Gary W. Franklin, Dennis P. Riley
Publikováno v:
ChemInform. 28
The synthesis of a bis-cyclohexyl-fused pentaazamacrocycle via head-to-tail pseudopeptide cyclization chemistry is described. The bis-cyclohexyl-fused cyclic pseudopeptide 11 displays intramolecular hydrogen bonding which has been characterized by va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a2f5abfcf4b7ba3cc21aecc4cb1dbb4
https://doi.org/10.1002/chin.199733210
https://doi.org/10.1002/chin.199733210