Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Randy E. Metzger"'
Autor:
Tianyuan Zhang, Richard A. G. Smith, Rohinton Edalji, Yu-Gui Gu, John L. Baranowski, William J. Sanders, Bruce A. Beutel, Liping Yu, Philip J. Hajduk, Annapur Gurulingappa Shivakumar, Stephan J. Kakavas, Frank L. Wagenaar, Darlene J. Balli, Steven F. Betz, Richard F. Clark, Kenneth M. Comess, Eric J. Hebert, J. Owen McCall, Jamey Mack, Linda E. Chovan, Randy E. Metzger, Thomas F. Holzman, Anne Y. Saiki, Sarah A. Dorwin, Niru B. Soni, Mai Bui, Angela M. Nilius, Susan J. Thornewell, Cooper Curt S, Mark E. Schurdak, Michael L. Coen, Rolf Wagner, Alan S. Florjancic, Philip J. Merta, Claude G. Lerner, Charlotte Woodall, Candace Black-Schaefer, John E. Harlan, Mengli Cai, Karl A. Walter, Xenia B. Searle, Stephen W. Fesik
Publikováno v:
Chemical Biology & Drug Design. 69:395-404
As part of a fully integrated and comprehensive strategy to discover novel antibacterial agents, NMR- and mass spectrometry-based affinity selection screens were performed to identify compounds that bind to protein targets uniquely found in bacteria
Autor:
Randy E. Metzger, Stephan J. Kakavas, Philip J. Merta, Xiaoan Ruan, Richard T. Chang, Claude G. Lerner, Christian Wagner, Bruce A. Beutel
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:2767-2777
Restriction enzyme modulation of transformation efficiencies (REMOTE) is a method that makes use of genome restriction maps and experimentally observed differences in transformation efficiencies of genomic DNA restriction digests to discover the loca
Autor:
Haixia Yu, Elizabeth A. Kowaluk, Bruce R. Bianchi, Randy E. Metzger, Michael F. Jarvis, Kevin J. Lynch, Tim van Biesen
Publikováno v:
Drug Development Research. 48:84-93
Adenosine-5'-O-3-thio[ 35 S]triphosphate ([ 35 S]-ATPγS) has been reported to specifically bind several P2X receptor subtypes, including P2X 1 , P2X 2 , P2X 3 , and P2X 4 . Similarly, adenosine-5'-O-2-thio[ 35 S]diphosphate ([ 35 S]-ADPβS) has been
Autor:
Tim van Biesen, Elizabeth A. Kowaluk, Kevin J. Lynch, Edward C. Burgard, Wende Niforatos, Michael F. Jarvis, Randy E. Metzger, Edward Touma
Publikováno v:
Journal of Neurophysiology. 82:1590-1598
Nociceptive neurons in the dorsal root ganglia (DRG) are activated by extracellular ATP, implicating P2X receptors as potential mediators of painful stimuli. However, the P2X receptor subtype(s) underlying this activity remain in question. Using elec
Autor:
Tim van Biesen, Elizabeth A. Kowaluk, Wende Niforatos, Kevin J. Lynch, Randy E. Metzger, Bruce R. Bianchi, Edward C. Burgard, Michael F. Jarvis, Karen M. Alexander, Helen S Park, Haixia Yu, Edward Touma
Publikováno v:
European journal of pharmacology. 376(1-2)
ATP functions as a fast neurotransmitter through the specific activation of a family of ligand-gated ion channels termed P2X receptors. In this report, six distinct recombinant P2X receptor subtypes were pharmacologically characterized in a heterolog
Autor:
Mary Jo LaDu, Jia B. Pan, Randy E. Metzger, Godfrey S. Getz, Donald E. Frail, Michael T. Falduto
Publikováno v:
Journal of neuropathology and experimental neurology. 55(3)
Apolipoprotein E (apoE) is a plasma protein that regulates lipid transport and cholesterol homeostasis. In humans, apoE occurs as 3 major isoforms (apoE2, E3, and E4). Genetic evidence demonstrates an overrepresentation of the apoE epsilon 4 allele i