Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Randy E. Keen"'
1
The elusive 8-fluoroadenosine
Autor: Nagichettiar Satyamurthy, Jorge R. Barrio, Mohammad Namavari, Randy E. Keen
Publikováno v: Tetrahedron Letters. 39:7231-7234
The synthesis of 8-fluoroadenosine has been accomplished for the first time. The kinetics of deamination of 8-fluoroadenosine with the enzyme adenosine deaminase has also been measured.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::190f3fcd4249f4a8c1f5a4b1b967cbde
https://doi.org/10.1016/s0040-4039(98)01594-9
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2
Analysis of Femtomole Concentrations of α-Ketoisocaproic Acid in Brain Tissue by Precolumn Fluorescence Derivatization with 4,5-Dimethoxy-1,2-diaminobenzene
Autor: C.H. Nissenson, J.R. Barrio, Randy E. Keen
Publikováno v: Analytical Biochemistry. 213:23-28
An extremely sensitive fluorimetric HPLC method used to determine in vivo cerebral alpha-ketoisocaproic acid (KIC) concentration with less than 2 g of tissue (e.g., a single rat brain, approximately 1.8 g) is reported. Removal of unwanted lipids and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285c208d44d66d951a6ac831d4af62cb
https://doi.org/10.1006/abio.1993.1380
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3
ChemInform Abstract: The Elusive 8-Fluoroadenosine
Autor: Mohammad Namavari, Jorge R. Barrio, Nagichettiar Satyamurthy, Randy E. Keen
Publikováno v: ChemInform. 30
The synthesis of 8-fluoroadenosine has been accomplished for the first time. The kinetics of deamination of 8-fluoroadenosine with the enzyme adenosine deaminase has also been measured.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2da63567a9d0f633ff207c05b8e776f0
https://doi.org/10.1002/chin.199901216
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6
Effects of inhibition of fatty acid oxidation on myocardial kinetics of 11C-labeled palmitate
Autor: Sung-Cheng Huang, Heinrich R. Schelbert, Carl Selin, William Wyns, Randy E. Keen, Denis B. Buxton, Markus Schwaiger, Herbert Hansen, Michael E. Phelps
Publikováno v: Scopus-Elsevier
The effects of glucose and lactate infusion on palmitate oxidation were compared with the effect of 2-tetradecylglycidic acid (TDGA), an irreversible inhibitor of the carnitine acyltransferase I, in normoxic canine myocardium. The initial capillary t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14df0d5ff41e913366b36d9019568e65
https://doi.org/10.1161/01.res.65.6.1787
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7
3-(2'-[18F]Fluoroethyl)Spiperone: In vivo Biochemical and Kinetic Characterization in Rodents, Nonhuman Primates, and Humans
Autor: Nagichettiar Satyamurthy, Michael E. Phelps, Robert F. Ackermann, Randy E. Keen, John C. Mazziotta, Sung-Cheng Huang, Mark M. Bahn, Charna H. K. Nissenson, Jorge R. Barrio, John M. Hoffman
Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 9:830-839
3-(2'-[18F]fluoroethyl)spiperone (FESP), a recently developed dopamine D2-receptor binding radiopharmaceutical, was used for dynamic characterization of dopamine-receptor binding in Macaca nemestrina monkeys and humans with positron emission tomograp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2131cc2d7d273e7535866a7feb4e2b9f
https://doi.org/10.1038/jcbfm.1989.117
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8
In vivo Cerebral Protein Synthesis Rates with Leucyl-Transfer RNA Used as a Precursor Pool: Determination of Biochemical Parameters to Structure Tracer Kinetic Models for Positron Emission Tomography
Autor: Randall A. Hawkins, Jorge R. Barrio, Sung-Cheng Huang, Michael E. Phelps, Randy E. Keen
Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 9:429-445
Leucine oxidation and incorporation into proteins were examined in the in vivo rat brain to determine rates and compartmentation of these processes for the purpose of structuring mathematical compartmental models for the noninvasive estimation of in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7cd41281b4d79cc3c42eb49b6ef62d6
https://doi.org/10.1038/jcbfm.1989.67
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9
Estimation of Local Cerebral Protein Synthesis Rates with L-[1-11C]Leucine and PET: Methods, Model, and Results in Animals and Humans
Autor: Dagan Feng, Sung-Cheng Huang, Michael E. Phelps, Randall A. Hawkins, John C. Mazziotta, Randy E. Keen, Jorge R. Barrio
Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 9:446-460
We have estimated the cerebral protein synthesis rates (CPSR) in a series of normal human volunteers and monkeys using l-[1-11C]leucine and positron emission tomography (PET) using a three-compartment model. The model structure, consisting of a tissu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ad72349a1101efa6b0dfc41ff95966
https://doi.org/10.1038/jcbfm.1989.68
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10
Criteria for the tracer kinetic measurement of cerebral protein synthesis in humans with positron emission tomography
Autor: John C. Mazziotta, J.R. Barrio, Sung-Cheng Huang, Michael E. Phelps, Harry T. Chugani, Randy E. Keen
Publikováno v: Annals of Neurology. 15:192-202
The principles and initial results of the use of PET to measure the local cerebral metabolic rate for protein synthesis (lCRPS) in humans are described. The labeling of leucine, phenylalanine, and methionine in the carboxyl position provides a strate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8496467cfb2fa35e2440361de415a6ac
https://doi.org/10.1002/ana.410150736
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