Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Randy B. Stockbridge"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Fluorinated organic chemicals, such as per- and polyfluorinated alkyl substances (PFAS) and fluorinated pesticides, are both broadly useful and unusually long-lived. To combat problems related to the accumulation of these compounds, microbia
Externí odkaz:
https://doaj.org/article/f1754c794d7841169c1d80942a9d0dd2
Autor:
Aditya Banerjee, Chia-Yu Kang, Minjun An, B. Ben Koff, Sham Sunder, Anuj Kumar, Livia M. A. Tenuta, Randy B. Stockbridge
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTMicroorganisms resist fluoride toxicity using fluoride export proteins from one of several different molecular families. Cariogenic species Streptococcus mutans and Candida albicans extrude intracellular fluoride using a CLCF F-/H+ antiporter
Externí odkaz:
https://doaj.org/article/e33318f0947d42c08a2844089bbbc133
Autor:
Betsy M. Martinez-Vaz, Anthony G. Dodge, Rachael M. Lucero, Randy B. Stockbridge, Ashley A. Robinson, Lambros J. Tassoulas, Lawrence P. Wackett
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Metformin is used globally to treat type II diabetes, has demonstrated anti-ageing and COVID mitigation effects and is a major anthropogenic pollutant to be bioremediated by wastewater treatment plants (WWTPs). Metformin is not adsorbed well by activ
Externí odkaz:
https://doaj.org/article/08c30f104ea544edbdd067c7cd19b32b
Autor:
Ali A. Kermani, Christian B. Macdonald, Olive E. Burata, B. Ben Koff, Akiko Koide, Eric Denbaum, Shohei Koide, Randy B. Stockbridge
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Gdx-Clo is a bacterial transporter from the small multidrug resistance (SMR) family. Here, the authors use solid supported membrane electrophysiology to characterize Gdx-Clo functionally and report crystal structures of Gdx-Clo which confirm the dual
Externí odkaz:
https://doaj.org/article/d4785d992fee4f28884dcfc5aaeb641b
Publikováno v:
eLife, Vol 11 (2022)
Proteins from the bacterial small multidrug resistance (SMR) family are proton-coupled exporters of diverse antiseptics and antimicrobials, including polyaromatic cations and quaternary ammonium compounds. The transport mechanism of the Escherichia c
Externí odkaz:
https://doaj.org/article/cc3ac98bd2e3424682e09d21aa8905a9
Publikováno v:
eLife, Vol 10 (2021)
Fluc family fluoride channels protect microbes against ambient environmental fluoride by undermining the cytoplasmic accumulation of this toxic halide. These proteins are structurally idiosyncratic, and thus the permeation pathway and mechanism have
Externí odkaz:
https://doaj.org/article/c090bf80bcab49db8a9299562aecdb5b
Autor:
Felichi Mae Arines, Aleksander Wielenga, Olive E. Burata, Francisco Narro Garcia, Randy B. Stockbridge, Ming Li
Publikováno v:
bioRxiv
Lysosomes achieve their function through numerous transporters that import or export nutrients across their membrane. However, technical challenges in membrane protein overexpression, purification, and reconstitution hinder our understanding of lysos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ecfe150bd3e916945c480408d9a6943
https://europepmc.org/articles/PMC10081341/
https://europepmc.org/articles/PMC10081341/
Autor:
Melanie Ernst, Esam A. Orabi, Randy B. Stockbridge, José D. Faraldo-Gómez, Janice L. Robertson
Publikováno v:
bioRxiv
Many ion channels are multi-subunit complexes with a polar permeation pathway at the oligomeric interface, but their mechanisms of assembly into functional, thermodynamically stable units within the membrane are largely unknown. Here we characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd15e639469eb6d29cdf4202f9107d7
https://europepmc.org/articles/PMC9928038/
https://europepmc.org/articles/PMC9928038/