Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Randy B. Howard"'
Publikováno v:
Journal of Neurotrauma
To date, outcomes for all Phase III clinical trials for traumatic brain injury (TBI) have been negative. The recent disappointing results of the Progesterone for the Treatment of Traumatic Brain Injury (ProTECT) and Study of a Neuroprotective Agent,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f8a8903ada2e69bff34197c9934152
https://doi.org/10.1089/neu.2015.4179
https://doi.org/10.1089/neu.2015.4179
Autor:
G. Prabhakar Reddy, Randy B. Howard, Richard F. Arrendale, David S. Menaldino, Sarah T. Pruett, Manohar Saindane, Dennis C. Liotta, Mark T. Baillie, Jason J. Holt, Deborah G. Culver, John A. Petros, Eric J. Miller, Michael G. Natchus, Taylor J. Evers, Suzanne G. Mays
Publikováno v:
ACS Medicinal Chemistry Letters. 7:537-542
The orally bioavailable 1-deoxy-sphingosine analog, Enigmol, has demonstrated anticancer activity in numerous in vivo settings. However, as no Enigmol analog with enhanced potency in vitro has been identified, a new strategy to improve efficacy in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f8cc417011a9fe835509db03dfa969
https://doi.org/10.1021/acsmedchemlett.6b00113
https://doi.org/10.1021/acsmedchemlett.6b00113
Despite hundreds of positive preclinical studies and two successful Phase II clinical trials, two large Phase III trials of progesterone treatment for traumatic brain injury were recently ended with no finding of any difference between the test drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df917de4c7b199c15840ebc7f969b00c
https://doi.org/10.1016/b978-0-12-802686-1.00001-8
https://doi.org/10.1016/b978-0-12-802686-1.00001-8
Autor:
David B. Guthrie, Richard F. Arrendale, Dennis C. Liotta, Fahim Atif, Randy B. Howard, Michael G. Natchus, Donald G. Stein, Deborah G. Culver, Jose R. Marengo, Mark A. Lockwood, G. Prabhakar Reddy, Iqbal Sayeed, Taylor J. Evers
Publikováno v:
ACS Medicinal Chemistry Letters. 3:362-366
After more than 30 years of research and 30 failed clinical trials with as many different treatments, progesterone is the first agent to demonstrate robust clinical efficacy as a treatment for traumatic brain injuries. It is currently being investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0189124b6b0aae85a83e76d1247dd58
https://doi.org/10.1021/ml200303r
https://doi.org/10.1021/ml200303r
Autor:
Jason J. Holt, John A. Petros, Anatoliy S. Bushnev, David S. Menaldino, Richard F. Arrendale, Lanny S. Liebeskind, Taylor J. Evers, Deborah G. Culver, G. Prabhakar Reddy, Suzanne G. Mays, Dennis C. Liotta, Mark T. Baillie, Randy B. Howard, Michael G. Natchus, Harsha Ramaraju, Ethel C. Garnier-Amblard
Publikováno v:
ACS Medicinal Chemistry Letters. 2:438-443
Enigmol is a synthetic, orally active 1-deoxysphingoid base analogue that has demonstrated promising activity against prostate cancer. In these studies, the pharmacologic roles of stereochemistry and N-methylation in the structure of enigmols were ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d5ee2a7ea75912e9db3c96fd6717af
https://doi.org/10.1021/ml2000164
https://doi.org/10.1021/ml2000164
Autor:
Zhihong Ye, Charles Q. Meng, Kimberly J. Worsencroft, James A. Sikorski, Randy B. Howard, Ki-Ling Suen, Martin A. Wasserman, Liming Ni, Jason W. Skudlarek, Jacob E. Simpson, Cynthia L. Sundell, Charles A. Kunsch, Amy Souder, M. David Weingarten, Elaine M. Marino
Publikováno v:
Journal of Medicinal Chemistry. 50:1304-1315
Starting from a simple chalcone template, structure-activity relationship (SAR) studies led to a series of carboxylated, heteroaryl-substituted chalcone derivatives as novel, potent inhibitors of vascular cell adhesion molecule-1 (VCAM-1) expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5756878f29e82e8d43f25c4437d306cc
https://doi.org/10.1021/jm0614230
https://doi.org/10.1021/jm0614230
Publikováno v:
Clinical & Experimental Metastasis. 17:157-162
The prevailing subcutaneous nude rodent tumor xenograft models used for biological and preclinical studies do not optimally reflect some important biological properties of cancer, especially invasion and metastasis. Orthotopic models have been develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5735c8ab6935a592228b7956cc855c6f
https://doi.org/10.1023/a:1006637712294
https://doi.org/10.1023/a:1006637712294
Autor:
Richard F. Arrendale, Nao Morii, Randy B. Howard, James P. Snyder, Deborah G. Culver, Dong M. Shin, Aiming Sun, Shijun Zhu, Fadlo R. Khuri, Hongzheng Zhang, Gabriel Sica, Haian Fu, Taylor J. Evers, Mamoru Shoji, Prabhakar Reddy, Zhuo Georgia Chen, Terry W. Moore
Publikováno v:
Current cancer drug targets. 14(4)
The natural compound curcumin has been investigated as an anticancer agent in many cellular systems, in animal models and in the clinic. The overriding negative characteristics of curcumin are its low solubility, weak potency and poor bioavailability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4919f3db475222ad09bf7f7a6ace449
https://pubmed.ncbi.nlm.nih.gov/24628271
https://pubmed.ncbi.nlm.nih.gov/24628271
Autor:
John A. Petros, Mark Baillie, Jingjing Gao, Taylor J. Evers, Michael G. Natchus, Eric J. Miller, Deborah G. Culver, Richard F. Arrendale, Suzanne G. Mays, G. Prakabahr Reddy, Randy B. Howard, Sarah T. Pruett, Anatoliy S. Bushnev, Dennis C. Liotta
Publikováno v:
Journal of Urology. 189
INTRODUCTION AND OBJECTIVES: Retroviral replicating vectors (RRVs) represent a novel gene delivery platform that can achieve efficient transduction of solid tumors through virus propagation within actively dividing cancer cells. FDA has already appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::313c4b791d36ef79789338f9b088802b
https://doi.org/10.1016/j.juro.2013.02.1715
https://doi.org/10.1016/j.juro.2013.02.1715
Autor:
Prabhakar Reddy, Aiming Sun, Xiaoqian Lin, Taylor J. Evers, Terry W. Moore, Dong M. Shin, Nao Morii, Hongzheng Zhang, Alessandra Mancini, Richard F. Arrendale, Zhuo Georgia Chen, Randy B. Howard, Mamoru Shoji, Fadlo R. Khuri, James P. Snyder, Shijun Zhu, Deborah G. Culver, Gabriel Sica, Haian Fu
Publikováno v:
Integrative biology : quantitative biosciences from nano to macro. 4(6)
Objectives are to examine the efficacy of new synthetic curcumin analogs EF31 in head and neck squamous cell carcinoma in vitro and in vivo, and study their pharmacokinetic and toxicologic effects in vivo. The synthesis of EF31 was described for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827d2defcb6248fc0b94681d9e97f238
https://pubmed.ncbi.nlm.nih.gov/22532032
https://pubmed.ncbi.nlm.nih.gov/22532032