Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Randolph Y Hampton"'
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41119 (2012)
Escherichia coli Shiga-like toxin 1 normally traffics to the endoplasmic reticulum (ER) in sensitive mammalian cells from where the catalytic A chain (SLTxA1) dislocates to the cytosol to inactivate ribosomes. Currently, no molecular details of the d
Externí odkaz:
https://doaj.org/article/3e467bd503c24aa9930490197ae9259f
Autor:
Margaret A. Wangeline, Sonya E. Neal, Matthew P. Flagg, Christopher Benner, Sascha H. Duttke, Sarah R. Holland, Randolph Y. Hampton
Publikováno v:
Molecular Biology of the Cell
Molecular biology of the cell, vol 32, iss 7
Molecular biology of the cell, vol 32, iss 7
Before their delivery to and degradation by the 26S proteasome, misfolded transmembrane proteins of the endoplasmic reticulum (ER) and inner-nuclear membrane (INM) must be extracted from lipid bilayers. This extraction process, known as retrotransloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aad18d98beaff7a12a0240fbed8875a
http://europepmc.org/articles/PMC8101470
http://europepmc.org/articles/PMC8101470
Autor:
Nidhi Vashistha, Randolph Y. Hampton, Amanjot Singh, Xin Tang, Peter Wipf, Jarrod W. Heck, Jeffrey L. Brodsky
Publikováno v:
Molecular biology of the cell, vol 31, iss 24
Molecular Biology of the Cell
Molecular Biology of the Cell
Chaperones can mediate both protein folding and degradation. This process is referred to as protein triage, which demands study to reveal mechanisms of quality control for both basic scientific and translational purposes. In yeast, many misfolded pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb149d34a92457890063f60206f954f
https://escholarship.org/uc/item/8h92z2fj
https://escholarship.org/uc/item/8h92z2fj
Publikováno v:
The Journal of biological chemistry, vol 292, iss 8
A surprising feature of endoplasmic reticulum (ER)-associated degradation (ERAD) is the movement, or retrotranslocation, of ubiquitinated substrates from the ER lumen or membrane to the cytosol where they are degraded by the 26S proteasome. Multispan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5130b808e60904058e39f640bb59864
https://doi.org/10.1074/jbc.m116.770610
https://doi.org/10.1074/jbc.m116.770610
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fad4d53223e9be29f6cb28d132a82848
https://doi.org/10.1096/fasebj.2019.33.1_supplement.351.3
https://doi.org/10.1096/fasebj.2019.33.1_supplement.351.3
Publikováno v:
Methods in enzymology. 619
Elimination of misfolded proteins by endoplasmic reticulum (ER)-associated protein degradation (ERAD) ensures that proteins proceeding through the secretory pathway are correctly folded and processed, which is critical to minimize ER stress. All ERAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::adef5403ea1a830317fcce257792c90e
https://pubmed.ncbi.nlm.nih.gov/30910017
https://pubmed.ncbi.nlm.nih.gov/30910017
Publikováno v:
Yeast (Chichester, England)REFERENCES. 36(10)
Yeast recombination cloning is a straightforward and powerful method for recombining a plasmid backbone with a specific DNA fragment. However, the utility of yeast recombination cloning is limited by the requirement for the backbone to contain an CEN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de911f2c6fb227d274041d15e25adb2d
https://pubmed.ncbi.nlm.nih.gov/31074531
https://pubmed.ncbi.nlm.nih.gov/31074531
Elimination of misfolded proteins by endoplasmic reticulum (ER)-associated protein degradation (ERAD) ensures that proteins proceeding through the secretory pathway are correctly folded and processed, which is critical to minimize ER stress. All ERAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e65777efd2ca4d1c9339b93ee079dfb
https://doi.org/10.1016/bs.mie.2019.01.002
https://doi.org/10.1016/bs.mie.2019.01.002
Autor:
Man Shi, Xiaoman Zhang, Daniel L. Kastner, Ellen M. Gravallese, Charles V. Rosadini, Murali K. Akula, Kira Gritsman, Donghai Wang, Susan Carpenter, Katherine A. Fitzgerald, Zhaozhao Jiang, Annie S Li, Randolph Y. Hampton, David Miao, Jonathan C. Kagan, Ruth M Gavin, Celia E Foster, Douglas T. Golenbock, Martin O. Bergo, Sorcha D. Forde, Jae Jin Chae, Neal S. Silverman, Gail Germain
Publikováno v:
Nature immunology
Nature immunology, vol 17, iss 8
Nature immunology, vol 17, iss 8
Deficiency in mevalonate kinase (MVK) causes systemic inflammation. However, the molecular mechanisms linking the mevalonate pathway to inflammation remain obscure. Geranylgeranyl pyrophosphate, a non-sterol intermediate of the mevalonate pathway, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98aa4f501b936205a8d7490d7749b7c5
https://doi.org/10.1038/ni.3487
https://doi.org/10.1038/ni.3487
Publikováno v:
iScience, vol 23, iss 9
iScience, Vol 23, Iss 9, Pp 101493-(2020)
iScience
iScience, Vol 23, Iss 9, Pp 101493-(2020)
iScience
Summary ER-associated degradation (ERAD) targets misfolded ER proteins for degradation. Retrotranslocation, a key feature of ERAD, entails removal of ubiquitinated substrates into the cytosol for proteasomal destruction. Recently, it has been shown t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ebc1244938f5bdadb445bd465f43c6
https://doi.org/10.1016/j.isci.2020.101493
https://doi.org/10.1016/j.isci.2020.101493