Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Randolph S. Faustino"'
Autor:
Farhan Rizvi, Claudia C. Preston, Larisa Emelyanova, Mohammed Yousufuddin, Maria Viqar, Omar Dakwar, Gracious R. Ross, Randolph S. Faustino, Ekhson L. Holmuhamedov, Arshad Jahangir
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 16 (2021)
Background Age‐related heart diseases are significant contributors to increased morbidity and mortality. Emerging evidence indicates that mitochondria within cardiomyocytes contribute to age‐related increased reactive oxygen species (ROS) generat
Externí odkaz:
https://doaj.org/article/e30e7c94a5c54f1888225464b3fc1d1e
Autor:
Tui Neri, Emilye Hiriart, Patrick P. van Vliet, Emilie Faure, Russell A. Norris, Batoul Farhat, Bernd Jagla, Julie Lefrancois, Yukiko Sugi, Thomas Moore-Morris, Stéphane Zaffran, Randolph S. Faustino, Alexander C. Zambon, Jean-Pierre Desvignes, David Salgado, Robert A. Levine, Jose Luis de la Pompa, André Terzic, Sylvia M. Evans, Roger Markwald, Michel Pucéat
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
There are few human models that can recapitulate valve development in vitro. Here, the authors derive human pre-valvular endocardial cells (HPVCs) from iPSCs and show they can recapitulate early valvulogenesis, and patient derived HPVCs have features
Externí odkaz:
https://doaj.org/article/e45f606ce5c6400ca0225b4e0d2ad5be
Autor:
Riley J. Leonard, Claudia C. Preston, Melanie E. Gucwa, Yohannes Afeworki, Arielle S. Selya, Randolph S. Faustino
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Externí odkaz:
https://doaj.org/article/c7df8ed4f99a4aecb80a3978885cbcf3
Autor:
Claudia C. Preston, Tricia D. Larsen, Julie A. Eclov, Eli J. Louwagie, Tyler C. T. Gandy, Randolph S. Faustino, Michelle L. Baack
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Background: Children born to diabetic or obese mothers have a higher risk of heart disease at birth and later in life. Using chromatin immunoprecipitation sequencing, we previously demonstrated that late-gestation diabetes, maternal high fat (HF) die
Externí odkaz:
https://doaj.org/article/d01e203d8b0442ee9496ebfff624e8c0
Autor:
Riley J. Leonard, Claudia C. Preston, Melanie E. Gucwa, Yohannes Afeworki, Arielle S. Selya, Randolph S. Faustino
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Functional variants in nuclear envelope genes are implicated as underlying causes of cardiopathology. To examine the potential association of single nucleotide variants of nucleoporin genes with cardiac disease, we employed a prognostic scoring appro
Externí odkaz:
https://doaj.org/article/71d0c88fbfae41e0a42a237eded1f1a3
Publikováno v:
Epigenomes, Vol 2, Iss 3, p 15 (2018)
Pancreatic cancer is an aggressive and intractable malignancy with high mortality. This is due in part to a high resistance to chemotherapeutics and radiation treatment conferred by diverse regulatory mechanisms. Among these, constituents of the nucl
Externí odkaz:
https://doaj.org/article/3462fc833fa846c5a622542a4be89738
Autor:
Randolph S. Faustino, Paul Cheung, Melanie N. Richard, Elena Dibrov, Annette L. Kneesch, Justin F. Deniset, Mirna N. Chahine, Kaitlin Lee, David Blackwood, Grant N. Pierce
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 3, Pp 654-662 (2008)
Nucleocytoplasmic trafficking is an essential and responsive cellular mechanism that directly affects cell growth and proliferation, and its potential to address metabolic challenge is incompletely defined. Ceramide is an antiproliferative sphingolip
Externí odkaz:
https://doaj.org/article/54ff12328a874a0dbcf2448d0156ec7d
Publikováno v:
Results and problems in cell differentiation. 70
The nucleus is a complex organelle with functions beyond being a simple repository for genomic material. For example, its actions in biomechanical sensing, protein synthesis, and epigenomic regulation showcase how the nucleus integrates multiple sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::504d31f2e5be893f4cb939ded4f72690
https://pubmed.ncbi.nlm.nih.gov/36348122
https://pubmed.ncbi.nlm.nih.gov/36348122
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 320:H2401-H2415
Cardiovascular adaptation underlies all athletic training modalities, with a variety of factors contributing to overall response during exercise-induced stimulation. In this regard the role of circulating biomarkers is a well-established and invaluab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1147b91c4007c9df4157901015f12a44
https://doi.org/10.1152/ajpheart.00894.2020
https://doi.org/10.1152/ajpheart.00894.2020
Publikováno v:
J Mol Cell Cardiol
Cardiovascular disease is a pressing health problem with significant global health, societal, and financial burdens. Understanding the molecular basis of polygenic cardiac pathology is thus essential to devising novel approaches for management and tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ef8a472432e43108a88b0e4e33c626
https://doi.org/10.1016/j.yjmcc.2020.02.010
https://doi.org/10.1016/j.yjmcc.2020.02.010