Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Randolph M. Johnson"'
A proof-of-concept transbuccal swab delivery of naloxone-HCL study using a mucoadhesive, plant-based film-forming resin formulation demonstrated comparable blood levels to benchmark intramuscular (IM) injection in highly predictive dog model. Results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e33f72542b2085196b8f7484a1d51793
https://doi.org/10.1101/2020.12.07.415372
https://doi.org/10.1101/2020.12.07.415372
Publikováno v:
Journal of Bone and Mineral Research. 8:891-898
The addition of Ca2+ or a variety of divalent cations increases intracellular Ca2+ in parathyroid cells and suppresses secretion. Since 1,4,5-inositol trisphosphate (IP3) and 1,3,4,5-inositol tetrakisphosphate (IP4) mediate Ca2+ mobilization in other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78f96c882e8ababc741849977305d84
https://doi.org/10.1002/jbmr.5650080715
https://doi.org/10.1002/jbmr.5650080715
Autor:
Harry A.J. Struijker-Boudier, Felix Theeuwes, Randolph M. Johnson, Jos F.M. Smits, J. J. Rob Hermans, Helma van Essen
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 301:672-678
Intrapericardial application of therapeutic agents may open perspectives for target-directed therapy of the diseased heart. This study was performed to investigate whether intrapericardial drug application is beneficial from a pharmacokinetic point o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8b7860458c54e0aa5c07d8ad962a0a
https://doi.org/10.1124/jpet.301.2.672
https://doi.org/10.1124/jpet.301.2.672
Immortalized Human Dorsal Root Ganglion Cells Differentiate into Neurons with Nociceptive Properties
Autor:
Dinah W. Y. Sah, Heather Raymon, Silke Thode, Christian Barrère, Randolph M. Johnson, Jose Pardinas, Glenn C. Friedman, Jiuying Zhou
Publikováno v:
The Journal of Neuroscience. 19:5420-5428
A renewable source of human sensory neurons would greatly facilitate basic research and drug development. We had established previously conditionally immortalized human CNS cell lines that can differentiate into functional neurons (Sah et al., 1997).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2e2386ed1e60ddc6963843566a9eaa
https://doi.org/10.1523/jneurosci.19-13-05420.1999
https://doi.org/10.1523/jneurosci.19-13-05420.1999
Autor:
Walter Hom Campbell Lee, Richard M. Eglen, A.N. Verity, Randolph M. Johnson, Preston A. Baecker
Publikováno v:
Molecular Brain Research. 69:209-222
To address the regulation of glial cell line-derived neurotrophic factor (GDNF) gene expression, we have isolated 5′ extended cDNAs, cloned the human GDNF gene, and characterized the promoter. GDNF-encoding 5′ extended cDNAs containing a novel ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00c9118146d5f672f11c5e475451e38
https://doi.org/10.1016/s0169-328x(99)00106-0
https://doi.org/10.1016/s0169-328x(99)00106-0
Autor:
Randolph M. Johnson, T.L. Wyatt, Richard M. Eglen, A.N. Verity, B. Hajos, Preston A. Baecker, Walter Hom Campbell Lee
Publikováno v:
Journal of Neuroscience Research. 55:187-197
Human SK-N-AS neuroblastoma and U-87MG glioblastoma cell lines were found to secrete relatively high levels of glial cell line–derived neurotrophic factor (GDNF). In response to growth factors, cytokines, and pharmacophores, the two cell lines diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a00da82aa4c4a1ace97cfd238d38dd1
https://doi.org/10.1002/(sici)1097-4547(19990115)55:2<187::aid-jnr6>3.0.co
https://doi.org/10.1002/(sici)1097-4547(19990115)55:2<187::aid-jnr6>3.0.co
Publikováno v:
Cellular Signalling. 10:321-330
The effects of tricyclodecan-9-yl xanthogenate (D609), an inhibitor of phosphatidylcholine-specific phospholipases, on PC12 cells were investigated. D609 repressed nerve growth factor (NGF)-mediated induction of c-fos mRNA with an IC50 approximately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8428b98a38ebb706129d70379ae49576
https://doi.org/10.1016/s0898-6568(98)00010-2
https://doi.org/10.1016/s0898-6568(98)00010-2
Autor:
Sarah Walter, Dirk B. Mendel, Jin Dong, Eiketsu Sho, Shawn T. Alexander, Julie Janes, Randolph M. Johnson, Amos Baruch, Derek Maclean, Felix Karim, Qun Yin
Publikováno v:
BMC Nephrology
Background AMG 416 is a novel peptide agonist of the calcium-sensing receptor (CaSR). This report describes the activity of AMG 416 in two different rodent models of uremia, compared in each case to cinacalcet, an approved therapeutic for secondary h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3135b73a46235af86a242d5e3970f02
https://pubmed.ncbi.nlm.nih.gov/24884838
https://pubmed.ncbi.nlm.nih.gov/24884838
Autor:
Qun Yin, Felix Karim, Tom Hunter, Randolph M. Johnson, Amos Baruch, Gregory Bell, James E. Tomlinson, Sarah Walter, Shawn T. Alexander, Julie Janes, Derek Maclean, Dirk B. Mendel, Jin Dong
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 346(2)
A novel peptide, AMG 416 (formerly KAI-4169, and with a United States Adopted Name: velcalcetide), has been identified that acts as an agonist of the calcium-sensing receptor (CaSR). This article summarizes the in vitro and in vivo characterization o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e72b9b4cd6ded00bbf0239829d61950
https://pubmed.ncbi.nlm.nih.gov/23674604
https://pubmed.ncbi.nlm.nih.gov/23674604
Autor:
Karen Chen, William C. Mobley, Scott E. Daniels, Randolph M. Johnson, Yuling Sun, Enrico Alleva, Elaine J. Carlson, Charles J. Epstein, David M. Holtzman, David J. Fontana, Daniela Santucci, Jane Chua-Couzens, Joshua Kilbridge
Publikováno v:
Proceedings of the National Academy of Sciences. 93:13333-13338
To study the pathogenesis of central nervous system abnormalities in Down syndrome (DS), we have analyzed a new genetic model of DS, the partial trisomy 16 (Ts65Dn) mouse. Ts65Dn mice have an extra copy of the distal aspect of mouse chromosome 16, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2159645de1c946917a664d7d373283c
https://doi.org/10.1073/pnas.93.23.13333
https://doi.org/10.1073/pnas.93.23.13333