Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains

Autor: Mostafavi, S, Ortiz-Lopez, A, Bogue, MA, Hattori, K, Pop, C, Koller, D, Mathis, D, Benoist, C, Blair, DA, Dustin, ML, Shinton, SA, Hardy, RR, Shay, T, Regev, A, Cohen, N, Brennan, P, Brenner, M, Kim, F, Rao, TN, Wagers, A, Heng, T, Ericson, J, Rothamel, K, Kreslavsky, T, Fletcher, A, Elpek, K, Bellemare-Pelletier, A, Malhotra, D, Turley, S, Miller, J, Brown, B, Merad, M, Gautier, EL, Jakubzick, C, Randolph, GJ, Monach, P, Best, AJ, Knell, J, Goldrath, A, Jojic, V, Laidlaw, D, Collins, J, Gazit, R, Rossi, DJ, Malhotra, N, Sylvia, K, Kang, J, Bezman, NA, Sun, JC, Min-Oo, G, Kim, CC, Lanier, LL

Publikováno v: Mostafavi, S; Ortiz-Lopez, A; Bogue, MA; Hattori, K; Pop, C; Koller, D; et al.(2014). Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains. Journal of Immunology, 193(9), 4485-4496. doi: 10.4049/jimmunol.1401280. UCSF: Retrieved from: http://www.escholarship.org/uc/item/2w43r09r

Copyright © 2014 by The American Association of Immunologists, Inc. All rights reserved. To determine the breadth and underpinning of changes in immunocyte gene expression due to genetic variation in mice, we performed, as part of the Immunological

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Transcriptional insights into the CD8 + T cell response to infection and memory T cell formation

Autor: Best, JA, Blair, DA, Knell, J, Yang, E, Mayya, V, Doedens, A, Dustin, ML, Goldrath, AW, Monach, P, Shinton, SA, Hardy, RR, Jianu, R, Koller, D, Collins, J, Gazit, R, Garrison, BS, Rossi, DJ, Narayan, K, Sylvia, K, Kang, J, Fletcher, A, Elpek, K, Bellemare-Pelletier, A, Malhotra, D, Turley, S, Jojic, V, Shay, T, Regev, A, Cohen, N, Brennan, P, Brenner, M, Kreslavsky, T, Bezman, NA, Sun, JC, Kim, CC, Lanier, LL, Miller, J, Brown, B, Merad, M, Gautier, EL, Jakubzick, C, Randolph, GJ, Kim, F, Rao, TN, Wagers, A, Heng, T, Painter, M, Ericson, J, Davis, S, Ergun, A, Mingueneau, M, Mathis, D, Benoist, C

Publikováno v: Best, JA; Blair, DA; Knell, J; Yang, E; Mayya, V; Doedens, A; et al.(2013). Transcriptional insights into the CD8 + T cell response to infection and memory T cell formation. Nature Immunology, 14(4), 404-412. doi: 10.1038/ni.2536. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3v72j79j

After infection, many factors coordinate the population expansion and differentiation of CD8+effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8+T cell transcriptome throughout in

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Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

Autor: Gautiar, EL, Shay, T, Miller, J, Greter, M, Jakubzick, C, Ivanov, S, Helft, J, Chow, A, Elpek, KG, Gordonov, S, Mazloom, AR, Ma'Ayan, A, Chua, WJ, Hansen, TH, Turley, SJ, Merad, M, Randolph, GJ, Best, AJ, Knell, J, Goldrath, A, Brown, B, Jojic, V, Koller, D, Cohen, N, Brenner, M, Regev, A, Fletcher, A, Bellemare-Pelletier, A, Malhotra, D, Jianu, R, Laidlaw, D, Collins, J, Narayan, K, Sylvia, K, Kang, J, Gazit, R, Garrison, BS, Rossi, DJ, Kim, F, Rao, TN, Wagers, A, Shinton, SA, Hardy, RR, Monach, P, Bezman, NA, Sun, JC, Kim, CC, Lanier, LL, Heng, T, Kreslavsky, T, Painter, M, Ericson, J, Davis, S, Mathis, D, Benoist, C

Publikováno v: Gautiar, EL; Shay, T; Miller, J; Greter, M; Jakubzick, C; Ivanov, S; et al.(2012). Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nature Immunology, 13(11), 1118-1128. doi: 10.1038/ni.2419. UCSF: Retrieved from: http://www.escholarship.org/uc/item/50c349sc

We assessed gene expression in tissue macrophages from various mouse organs. The diversity in gene expression among different populations of macrophages was considerable. Only a few hundred mRNA transcripts were selectively expressed by macrophages r

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Deciphering the transcriptional network of the dendritic cell lineage

Autor: Miller, JC, Brown, BD, Shay, T, Gautier, EL, Jojic, V, Cohain, A, Pandey, G, Leboeuf, M, Elpek, KG, Helft, J, Hashimoto, D, Chow, A, Price, J, Greter, M, Bogunovic, M, Bellemare-Pelletier, A, Frenette, PS, Randolph, GJ, Turley, SJ, Merad, M, Jakubzick, C, Best, AJ, Knell, J, Goldrath, A, Koller, D, Cohen, N, Brennan, P, Brenner, M, Regev, A, Fletcher, A, Malhotra, D, Jianu, R, Laidlaw, D, Collins, J, Narayan, K, Sylvia, K, Kang, J, Gazit, R, Rossi, DJ, Kim, F, Rao, TN, Wagers, A, Shinton, SA, Hardy, RR, Monach, P, Bezman, NA, Sun, JC, Kim, CC, Lanier, LL, Heng, T, Kreslavsky, T, Painter, M, Ericson, J, Davis, S, Mathis, D, Benoist, C

Publikováno v: Miller, JC; Brown, BD; Shay, T; Gautier, EL; Jojic, V; Cohain, A; et al.(2012). Deciphering the transcriptional network of the dendritic cell lineage. Nature Immunology, 13(9), 888-899. doi: 10.1038/ni.2370. UCSF: Retrieved from: http://www.escholarship.org/uc/item/4mb583kw

Although much progress has been made in the understanding of the ontogeny and function of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and functional specialization of DCs in vivo remains poorly understood. We made

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A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control.

Autor: Wang Y; Department of Immunology, Harvard Medical School, Boston, MA, USA., Zhang Y; Department of Immunology, Harvard Medical School, Boston, MA, USA., Kim K; Center for Bacterial Pathogenesis and Department of Microbiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Han J; Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA., Okin D; Division of Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Jiang Z; Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Yang L; Department of Immunology, Harvard Medical School, Boston, MA, USA., Subramaniam A; Immunology and Inflammatory Research Therapeutic Area, Sanofi, Cambridge, MA, USA., Means TK; Immunology and Inflammatory Research Therapeutic Area, Sanofi, Cambridge, MA, USA., Nestlé FO; Immunology and Inflammatory Research Therapeutic Area, Sanofi, Cambridge, MA, USA., Fitzgerald KA; Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Randolph GJ; Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA., Lesser CF; Center for Bacterial Pathogenesis and Department of Microbiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Kagan JC; Division of Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Mathis D; Department of Immunology, Harvard Medical School, Boston, MA, USA., Benoist C; Department of Immunology, Harvard Medical School, Boston, MA, USA. Electronic address: cbdm@hms.harvard.edu.

Publikováno v: Immunity [Immunity] 2024 Nov 14. Date of Electronic Publication: 2024 Nov 14.