Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Randolph B. Lyde"'
Autor:
Danuta Jarocha, Karen K. Vo, Randolph B. Lyde, Vincent Hayes, Rodney M. Camire, Mortimer Poncz
Publikováno v:
Blood Advances, Vol 2, Iss 6, Pp 597-606 (2018)
Abstract: In vitro–grown megakaryocytes for generating platelets may have value in meeting the increasing demand for platelet transfusions. Remaining challenges have included the poor yield and quality of in vitro–generated platelets. We have sho
Externí odkaz:
https://doaj.org/article/6a32f8cb9c0048188ece2a9643465952
Autor:
Debasis Panda, Patrick P. Rose, Sheri L. Hanna, Beth Gold, Kaycie C. Hopkins, Randolph B. Lyde, Michael S. Marks, Sara Cherry
Publikováno v:
Cell Reports, Vol 5, Iss 6, Pp 1737-1748 (2013)
Alphaviruses are a large class of insect-borne human pathogens and little is known about the host-factor requirements for infection. To identify such factors, we performed a genome-wide RNAi screen using model Drosophila cells and validated 94 genes
Externí odkaz:
https://doaj.org/article/53a34a59c26e4154a0232173e340e8d0
Autor:
Randolph B. Lyde, Stephanie J. Fagbemi, Orayinka Orafidiya, Mahdieh Hosseini, Amanda Pirola, John M. Cipriaso, Amy J. Goldberg, Maria Zimmerman, Kathleen Reeves, Jacob W. Ufberg
Publikováno v:
Academic Medicine. 97:S135-S135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1020e37cef14c035be3ebc2dc1a9d381
https://doi.org/10.1097/acm.0000000000004860
https://doi.org/10.1097/acm.0000000000004860
Autor:
Randolph B. Lyde, Vincent Hayes, Mortimer Poncz, Danuta Jarocha, Rodney M. Camire, Karen K. Vo
Publikováno v:
Blood Advances. 2:597-606
In vitro-grown megakaryocytes for generating platelets may have value in meeting the increasing demand for platelet transfusions. Remaining challenges have included the poor yield and quality of in vitro-generated platelets. We have shown that infusi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184cadc111cb62131dee0dd4b9bfcd49
https://doi.org/10.1182/bloodadvances.2017010975
https://doi.org/10.1182/bloodadvances.2017010975
Autor:
Christopher S. Thom, Vincent Hayes, Danuta Jarocha, Mortimer Poncz, Deborah L. French, Karen K. Vo, Randolph B. Lyde, Spencer K. Sullivan
Publikováno v:
Blood. 129:3486-3494
Friend leukemia virus integration 1 (FLI1), a critical transcription factor (TF) during megakaryocyte differentiation, is among genes hemizygously deleted in Jacobsen syndrome, resulting in a macrothrombocytopenia termed Paris-Trousseau syndrome (PTS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c5eb1b25d3e63c7a9371e1455d78ec
https://doi.org/10.1182/blood-2017-02-770958
https://doi.org/10.1182/blood-2017-02-770958
Publikováno v:
Journal of Thrombosis and Haemostasis. 13:S143-S150
We have proposed that modified platelets could potentially be used to correct intrinsic platelet defects as well as for targeted delivery of therapeutic molecules to sights of vascular injury. Ectopic expression of proteins within α-granules prior t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aee0ffef52fb10cacbd9457ab957f6b
https://doi.org/10.1111/jth.12938
https://doi.org/10.1111/jth.12938
Autor:
Li Zhai, Randolph B. Lyde, Rodney M. Camire, Denise E. Sabatino, Mortimer Poncz, Michele P. Lambert, Valder R. Arruda, S. C. Bailey, Teshell K. Greene
Publikováno v:
Journal of Thrombosis and Haemostasis. 12:2102-2112
Summary Background Ectopically expressed B-domainless factor VIII in megakaryocytes is stored in α-granules, is effective in a number of murine hemostatic models, and is protected from circulating inhibitors. However, this platelet (p) FVIII has dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d38868887e6164e87d4e2811189468
https://doi.org/10.1111/jth.12749
https://doi.org/10.1111/jth.12749
Autor:
Rodney M. Camire, John Tkaczynski, Danuta Jarocha, Denise E. Sabatino, Mortimer Poncz, Randolph B. Lyde, Hyun Sook Ahn, Deborah L. French, Karen K. Vo, Spencer K. Sullivan, Elsa Treffeisen
Publikováno v:
Blood advances. 3(9)
B-domainless factor VIII (FVIII) ectopically expressed in megakaryocytes (MKs) is stored in α granules of platelets (pFVIII) and is capable of restoring hemostasis in FVIIInull mice, even in the presence of circulating inhibitors. However, our prior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7736679ae7d53b47302efbf237b5467c
https://pubmed.ncbi.nlm.nih.gov/31036722
https://pubmed.ncbi.nlm.nih.gov/31036722
Publikováno v:
Platelets in Thrombotic and Non-Thrombotic Disorders ISBN: 9783319474601
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb4123731941dd8e6c359ccd3887d33b
https://doi.org/10.1007/978-3-319-47462-5_94
https://doi.org/10.1007/978-3-319-47462-5_94
Autor:
Kimberly A. Kraynyak, Emma L. Reuschel, Devin J.F. Myles, Niranjan Y. Sardesai, Jian Yan, A Muthumani, Daniel K. Choo, Terri H. Finkel, Jong J. Kim, Randolph B. Lyde, DB Weiner, L P Weiner, T C Gorham, Kenneth E. Ugen, Karuppiah Muthumani, Colleen Tingey
Publikováno v:
Cancer Gene Therapy. 21:507-517
Melanoma is the most deadly type of skin cancer, constituting annually ∼ 75% of all cutaneous cancer-related deaths due to metastatic spread. Currently, because of metastatic spread, there are no effective treatment options for late-stage metastati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662bd1e8e32ebbfce418dd4fbd7bce5e
https://doi.org/10.1038/cgt.2014.56
https://doi.org/10.1038/cgt.2014.56