Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Rando Porosk"'
Autor:
Emmelie Cansby, Sima Kumari, Mara Caputo, Ying Xia, Rando Porosk, Jonathan Robinson, Hao Wang, Britt-Marie Olsson, Josefine Vallin, Julie Grantham, Ursel Soomets, L. Thomas Svensson, Carina Sihlbom, Hanns-Ulrich Marschall, Andreas Edsfeldt, Isabel Goncalves, Margit Mahlapuu
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Silencing of STK25, an STE20-type kinase, in human aortic endothelial and smooth muscle cells reduces lipid accumulation and suppresses inflammation and fibrotic pathways, ultimately exerting atheroprotective effects.
Externí odkaz:
https://doaj.org/article/c671ada46a694cea94aa6e66b65dc4a6
Autor:
Sumit Kumar Anand, Mara Caputo, Ying Xia, Emma Andersson, Emmelie Cansby, Sima Kumari, Marcus Henricsson, Rando Porosk, Katharina Susanne Keuenhof, Johanna Louise Höög, Syam Nair, Hanns-Ulrich Marschall, Matthias Blüher, Margit Mahlapuu
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 7, Pp 100238- (2022)
The primary hepatic consequence of obesity is non-alcoholic fatty liver disease (NAFLD), affecting about 25% of the global adult population. Non-alcoholic steatohepatitis (NASH) is a severe form of NAFLD characterized by liver lipid accumulation, inf
Externí odkaz:
https://doaj.org/article/27fa9e174f6b494d9c0fcdb5a2bacb3c
Autor:
Ying Xia, Mara Caputo, Emmelie Cansby, Sumit Kumar Anand, Silva Sütt, Marcus Henricsson, Rando Porosk, Hanns-Ulrich Marschall, Matthias Blüher, Margit Mahlapuu
Publikováno v:
Molecular Metabolism, Vol 54, Iss , Pp 101353- (2021)
Objective: Nonalcoholic fatty liver disease (NAFLD), defined by excessive lipid storage in hepatocytes, has recently emerged as a leading global cause of chronic liver disease. The aim of this study was to examine the role of STE20-type protein kinas
Externí odkaz:
https://doaj.org/article/63503fb6b70f4a4db99a079b5a33ff2c
Autor:
Emmelie Cansby, Mara Caputo, Lei Gao, Nagaraj M. Kulkarni, Annika Nerstedt, Marcus Ståhlman, Jan Borén, Rando Porosk, Ursel Soomets, Matteo Pedrelli, Paolo Parini, Hanns-Ulrich Marschall, Jenny Nyström, Brian W. Howell, Margit Mahlapuu
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
Diabetic kidney disease (DKD) is the most common cause of severe renal disease worldwide and the single strongest predictor of mortality in diabetes patients. Kidney steatosis has emerged as a critical trigger in the pathogenesis of DKD; however, the
Externí odkaz:
https://doaj.org/article/76ee7c613d244adda29bbfe316fe4d15
Autor:
Maria Kaare, Kaie Mikheim, Kersti Lilleväli, Kalle Kilk, Toomas Jagomäe, Este Leidmaa, Maria Piirsalu, Rando Porosk, Katyayani Singh, Riin Reimets, Egon Taalberg, Michael K. E. Schäfer, Mario Plaas, Eero Vasar, Mari-Anne Philips
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1148 (2021)
In the large GWAS studies, NEGR1 gene has been one of the most significant gene loci for body mass phenotype. The purpose of the current study was to clarify the role of NEGR1 in the maintenance of systemic metabolism, including glucose homeostasis,
Externí odkaz:
https://doaj.org/article/3fa39a5f9bad4a3b8a594aac064199b7
Publikováno v:
Journal of Chemistry, Vol 2019 (2019)
A glutathione (L-γ-glutamyl-L-cysteinylglycine, GSH) analogue, UPF1 (O-methyl-L-tyrosinylglutathione), has been shown to increase intracellular concentration of total glutahione (tGSH) in K562 cells. The synthesis of GSH is a two-step process that r
Externí odkaz:
https://doaj.org/article/744d07f6ceee4f41a41262600e45a878
Autor:
Ying Xia, Emma Andersson, Sumit K. Anand, Emmelie Cansby, Mara Caputo, Sima Kumari, Rando Porosk, Kalle Kilk, Syam Nair, Hanns-Ulrich Marschall, Matthias Blüher, Margit Mahlapuu
Publikováno v:
Hepatology Communications. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c28e4b7d6cdaa5a5d56861fae09755a
https://doi.org/10.1097/hc9.0000000000000037
https://doi.org/10.1097/hc9.0000000000000037
Publikováno v:
Toxins, Vol 11, Iss 2, p 103 (2019)
The potentially self-poisonous toxin-antitoxin modules are widespread in bacterial chromosomes, but despite extensive studies, their biological importance remains poorly understood. Here, we used whole-cell proteomics to study the cellular effects of
Externí odkaz:
https://doaj.org/article/85a7f801582b463dabd4ae5e7191090f
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142053 (2015)
E-cigarettes are widely believed to be safer than conventional cigarettes and have been even suggested as aids for smoking cessation. However, while reasonable with some regards, this judgment is not yet supported by adequate biomedical research data
Externí odkaz:
https://doaj.org/article/15195fe6ed35496594106bff572e28ce
Autor:
Kattri-Liis Eskla, Hans Vellama, Liisi Tarve, Hillar Eichelmann, Toomas Jagomäe, Rando Porosk, Vello Oja, Heikko Rämma, Nadežda Peet, Agu Laisk, Vallo Volke, Eero Vasar, Hendrik Luuk
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 10108
Ischemia reperfusion injury is common in transplantation. Previous studies have shown that cooling can protect against hypoxic injury. To date, the protective effects of hypothermia have been largely associated with metabolic suppression. Since kidne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6383ae57e467447dc52a4a3ea14a740
https://doi.org/10.3390/ijms231710108
https://doi.org/10.3390/ijms231710108