Ipilimumab and nivolumab combined with anthracycline-based chemotherapy in metastatic hormone receptor-positive breast cancer: a randomized phase 2b trial

Autor: Ragnhild Sørum Falk, Bjornar Gilje, Andrea Gombos, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Claire Quaghebeur, Beate Boge, Randi R. Mathiesen, Lars Julsrud, Øystein Garred, Hege G. Russnes, Ragnhild Reehorst Lereim, Sudhir Kumar Chauhan, Ole Christian Lingjærde, Claire Dunn, Bjørn Naume, Jon Amund Kyte

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 1 (2024)

Background Immune checkpoint inhibitors have shown minimal clinical activity in hormone receptor-positive metastatic breast cancer (HR+mBC). Doxorubicin and low-dose cyclophosphamide are reported to induce immune responses and counter regulatory T ce

Externí odkaz: https://doaj.org/article/e9ba64ad31414caeaea3d72626619d91

Abstract P1-08-21: Detection and monitoring of circulating endothelial cells, circulating tumor cells and disseminated tumor cells during neoadjuvant breast cancer treatment including bevacizumab

Autor: I Stav, Erik Wist, Elin Borgen, Randi R. Mathiesen, Olav Engebråten, Cecilie Bendigtsen Schirmer, Bjørn Naume, Anna Barbro Sætersdal, MW Fagerland, Anne Fangberget

Publikováno v: Cancer Research. 73:P1-08

Background: Results from studies with bevacizumab in addition to traditional neoadjuvant therapy (NAT) indicate a need for predictive biomarkers. As a sub-study of the NeoAva study (a neoadjuvant study), the aim was to investigate the potential assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e9f34af49a416dc8e2426f6557d4fdf
https://doi.org/10.1158/0008-5472.sabcs13-p1-08-21

Persistence of disseminated tumor cells after neoadjuvant treatment for locally advanced breast cancer predicts poor survival

Autor: Terje Risberg, Bjørn Østenstad, Per Eystein Lønning, Erik Løkkevik, Elin Borgen, Ingvil Mjaaland, Anne Renolen, Bjørn Naume, Gunnar Kvalheim, Randi R. Mathiesen, Steinar Lundgren, Jahn M. Nesland, Gun Anker

Publikováno v: R117
Breast Cancer Research
Breast Cancer Research : BCR

Introduction Presence of disseminated tumor cells (DTCs) in bone marrow (BM) and circulating tumor cells (CTC) in peripheral blood (PB) predicts reduced survival in early breast cancer. The aim of this study was to determine the presence of and alter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf28def83d855ce726367c12f5c63e6f
https://hdl.handle.net/1956/8710

Abstract LB-051: Tumor heterogeneity and dissemination in breast cancer: Deep sequencing of single disseminated cells from bone marrow compared to primary tumor and lymph node metastases

Autor: Peter Van Loo, Jason Grundstad, April Peterson, Thierry Voet, Randi R. Mathiesen, Vessela N. Kristensen, Elin Borgen, Parveen Kumar, Renathe Fjelldal, Masoud Zamani Esteki, Lars Oliver Baumbusch, David C. Wedge, Silje Nord, Elen K. Møller, Anne Lise Børresen-Dale, Bjørn Naume, Kevin P. White

Publikováno v: Cancer Research. 75:LB-051

Metastasis is the main cause of death amongst breast cancer patients. Our knowledge of the metastatic cascade and how to inhibit it is limited. Here we dissect the genetic profile of multiple single disseminated tumor cells (DTCs) taken at various ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4aa2ca2068814836b9e40a73d9c6c744
https://doi.org/10.1158/1538-7445.am2015-lb-051

Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing

Autor: Vessela N. Kristensen, Jonas Demeulemeester, Silje Nord, Elia Fernandez Gallardo, Parveen Kumar, Koen Theunis, Renathe Fjelldal, Elen K. Møller, Lars Oliver Baumbusch, Peter Van Loo, Randi R. Mathiesen, Anne Lise Børresen-Dale, Elin Borgen, Kevin P. White, Masoud Zamani Esteki, David C. Wedge, Bjørn Naume, A. Jason Grundstad, April Peterson, Thierry Voet

Publikováno v: Europe PubMed Central
Genome Biology
Demeulemeester, J, Kumar, P, Møller, EK, Nord, S, Wedge, DC, Peterson, A, Mathiesen, RR, Fjelldal, R, Zamani, E M, Theunis, K, Fernandez, G E, Grundstad, AJ, Borgen, E, Baumbusch, LO, Børresen-Dale, AL, White, KP, Kristensen, VN, Van, L P, Voet, T & Naume, B 2016, ' Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing. ', Genome biology . https://doi.org/10.1186/s13059-016-1109-7

Background Single-cell micro-metastases of solid tumors often occur in the bone marrow. These disseminated tumor cells (DTCs) may resist therapy and lay dormant or progress to cause overt bone and visceral metastases. The molecular nature of DTCs rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76765569112501021c481c6980909f81
http://ora.ox.ac.uk/objects/uuid: