Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Randi M Simmons"'
Autor:
Tom Graddis, Valerie Wall, Meghan Zuck, Ray Fox, Kamal D. Puri, Myriam Bouchlaka, Darbie Whitman, Randi M Simmons, Peter Probst, Huyen Dinh, Sam Lam
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundOR2805 antibody was discovered using B cells derived from an elite responder to checkpoint inhibitor (CPI) therapy. It is a fully human IgG1 antibody that binds to CD163, an immune-suppressive receptor highly expressed on tumor associated m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb19e837b7e11927691a0cb1d4446bc
https://doaj.org/article/0bec906e607e4397b8846563cc9eb68c
https://doaj.org/article/0bec906e607e4397b8846563cc9eb68c
Autor:
Valerie Wall, Randi M Simmons, Meghan Zuck, Sam Lam, Myriam Bouchlaka, Peter Probst, Kamal D. Puri, Darbie Whitman, Raymond D. Fox, Tom Graddis
Publikováno v:
Cancer Research. 81:1719-1719
Background: OR2805 is a fully human IgG1 antibody that binds to CD163, an immune-suppressive receptor highly expressed on tumor associated macrophages (TAMs). High numbers of CD163-expressing TAMs generally predict an unfavorable prognosis in solid t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cda44523aae508239702ae22cb597c1
https://doi.org/10.1158/1538-7445.am2021-1719
https://doi.org/10.1158/1538-7445.am2021-1719
Autor:
Alan Aderem, William R. Henderson, Randi M. Simmons, Mark Gilchrist, Kelly D. Smith, Xin Ye, April E. Clark
Publikováno v:
The Journal of Experimental Medicine
We recently demonstrated the pivotal role of the transcription factor (TF) activating TF 3 (ATF3) in dampening inflammation. We demonstrate that ATF3 also ameliorates allergen-induced airway inflammation and hyperresponsiveness in a mouse model of hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7801c46a7809d1ffa2449f1f337abc
https://doi.org/10.1084/jem.20072254
https://doi.org/10.1084/jem.20072254
Publikováno v:
Blood. 106:2543-2550
Dectin-1 is a lectin receptor for β-glucan that is important for innate macrophage recognition of fungi and contributes to phagocytosis, reactive oxygen production, and induction of inflammatory cytokines. The mechanisms by which Dectin-1 mediates i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ced3b8c390d566f6256fc279da3f86
https://doi.org/10.1182/blood-2005-03-1239
https://doi.org/10.1182/blood-2005-03-1239
Autor:
Timothy W. Petersen, Alan Aderem, Cho Chou Kuo, Randi M. Simmons, Elizabeth S. Gold, Lee Ann Campbell
Publikováno v:
The Journal of Experimental Medicine
Macrophages play a critical role in both innate and acquired immunity because of their unique ability to internalize, kill, and degrade bacterial pathogens through the process of phagocytosis. The adaptor protein, amphiphysin IIm, participates in pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e94b47b6ac985c918d5a05857afc59
https://doi.org/10.1084/jem.20040546
https://doi.org/10.1084/jem.20040546
Publikováno v:
The Journal of Experimental Medicine
Toll-like receptors (TLRs) mediate recognition of a wide range of microbial products including lipopolysaccharides, lipoproteins, flagellin, and bacterial DNA, and signaling through TLRs leads to the production of inflammatory mediators. In addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efcf11bc4dc462cff1a75225a7b01620
http://europepmc.org/articles/PMC2193968
http://europepmc.org/articles/PMC2193968
Autor:
J. Scott Brockenbrough, Markus A. Carlson, Sunil R. Hingorani, Carlos Cuevas, Randi M Simmons, Philip D. Greenberg, Kamel Izeradjene, Ingunn M. Stromnes
Background Pancreatic ductal adenocarcinoma (PDA) is characterised by a robust desmoplasia, including the notable accumulation of immunosuppressive cells that shield neoplastic cells from immune detection. Immune evasion may be further enhanced if th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0c89fded41c5680ff2b718f435ef3b
https://europepmc.org/articles/PMC4340484/
https://europepmc.org/articles/PMC4340484/
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 178(5)
Innate immune pattern recognition receptors play critical roles in pathogen detection and initiation of antimicrobial responses. We and others have previously demonstrated the importance of the β-glucan receptor Dectin-1 in the recognition of pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb0384581eed0845af5aff70d0c09b6
https://pubmed.ncbi.nlm.nih.gov/17312158
https://pubmed.ncbi.nlm.nih.gov/17312158
The ability of Candida albicans to rapidly and reversibly switch between yeast and filamentous morphologies is crucial to pathogenicity, and it is thought that the filamentous morphology provides some advantage during interaction with the mammalian i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::853c84fb5f18439ec3bccc9552e7aa21
https://europepmc.org/articles/PMC556398/
https://europepmc.org/articles/PMC556398/