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pro vyhledávání: '"Randi L. Brown"'
Autor:
Joseph M. Luettgen, Carol A. Watson, Pancras C. Wong, Cailan Wang, Mark R. Harpel, Vidhyashankar Ramamurthy, Ge Zhang, Jeffrey M. Bozarth, Tara L. Peterson, Francis J. Woerner, Dietmar A. Seiffert, Alan R. Rendina, Frank A. Barbera, Karen A. Rossi, Ruth R. Wexler, Randi L. Brown, Joanne M. Smallheer, Paul E. Morin, Mimi L. Quan, Anzhi Wei
Publikováno v:
Journal of Medicinal Chemistry. 57:955-969
Antithrombotic agents that are inhibitors of factor XIa (FXIa) have the potential to demonstrate robust efficacy with a low bleeding risk profile. Herein, we describe a series of tetrahydroquinoline (THQ) derivatives as FXIa inhibitors. Compound 1 wa