Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Randi L, Guest"'
Autor:
Meera Gupta, Alex N. T. Johnson, Edward R. Cruz, Eli J. Costa, Randi L. Guest, Sophia Hsin-Jung Li, Elizabeth M. Hart, Thao Nguyen, Michael Stadlmeier, Benjamin P. Bratton, Thomas J. Silhavy, Ned S. Wingreen, Zemer Gitai, Martin Wühr
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Protein turnover is critical for proteostasis, but turnover quantification is challenging, and even in well-studied E. coli, proteome-wide measurements remain scarce. Here, we quantify the turnover rates of ~3200 E. coli proteins under 13 co
Externí odkaz:
https://doaj.org/article/d913f8136cf8490eb1880e204cbc7e2a
Autor:
Kathryn A. MacGillivray, Siu Lung Ng, Sophia Wiesenfeld, Randi L. Guest, Tahrima Jubery, Thomas J. Silhavy, William C. Ratcliff, Brian K. Hammer
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108332- (2023)
Summary: The Type VI Secretion System (T6SS) is a nano-harpoon used by many bacteria to inject toxins into neighboring cells. While much is understood about mechanisms of T6SS-mediated toxicity, less is known about the ways that competitors can defen
Externí odkaz:
https://doaj.org/article/1ff95540f131462b878a451247bb5808
Publikováno v:
Frontiers in Microbiology, Vol 12 (2022)
The Cpx envelope stress response is a major signaling pathway monitoring bacterial envelope integrity, activated both internally by excessive synthesis of membrane proteins and externally by a variety of environmental cues. The Cpx regulon is enriche
Externí odkaz:
https://doaj.org/article/9465965164ce4ad382c0f434867fe65b
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Lipopolysaccharide (LPS) is an essential glycolipid present in the outer membrane (OM) of many Gram-negative bacteria. Balanced biosynthesis of LPS is critical for cell viability; too little LPS weakens the OM, while too much LPS is lethal.
Externí odkaz:
https://doaj.org/article/0a802e1209834c37b465cfe2a17115bf
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
The Cpx response is one of several envelope stress responses that monitor and maintain the integrity of the gram-negative bacterial envelope. While several conditions that are known or predicted to generate misfolded inner membrane proteins activate
Externí odkaz:
https://doaj.org/article/ea4f0e8cdb5048fd98a329d0c6bfc579
Publikováno v:
Trends Microbiol
The outer membrane (OM) is a defining feature of Gram-negative bacteria that serves as a permeability barrier and provides rigidity to the cell. Critical to OM function is establishing and maintaining an asymmetrical bilayer structure with phospholip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9e7331906348d28033cbcb44996e9d
https://doi.org/10.1016/j.tim.2020.09.008
https://doi.org/10.1016/j.tim.2020.09.008
Autor:
Randi L, Guest, Thomas J, Silhavy
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1870:119405
The outer membrane is a distinguishing feature of the Gram-negative envelope. It lies on the external face of the peptidoglycan sacculus and forms a robust permeability barrier that protects extracytoplasmic structures from environmental insults. Ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46646b42baca97379548c7c095f78586
https://doi.org/10.1016/j.bbamcr.2022.119405
https://doi.org/10.1016/j.bbamcr.2022.119405
Publikováno v:
Frontiers in microbiology. 12
The Cpx envelope stress response is a major signaling pathway monitoring bacterial envelope integrity, activated both internally by excessive synthesis of membrane proteins and externally by a variety of environmental cues. The Cpx regulon is enriche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4ae40c2e87ca5d6dcbe58ee0afa4856
https://pubmed.ncbi.nlm.nih.gov/35154019
https://pubmed.ncbi.nlm.nih.gov/35154019
Publikováno v:
mBio, Vol 11, Iss 2, p e00598-20 (2020)
mBio, Vol 11, Iss 2 (2020)
mBio
mBio, Vol 11, Iss 2 (2020)
mBio
Gram-negative bacteria are encapsulated by an outer membrane (OM) that is impermeable to large and hydrophobic molecules. As such, these bacteria are intrinsically resistant to several clinically relevant antibiotics. To better understand how the OM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceda722f5a71905c8191f977d2c8bb54
https://doaj.org/article/ab331af5b9d54c7288d74d2d90b98cde
https://doaj.org/article/ab331af5b9d54c7288d74d2d90b98cde
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
The Cpx response is one of several envelope stress responses that monitor and maintain the integrity of the gram-negative bacterial envelope. While several conditions that are known or predicted to generate misfolded inner membrane proteins activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8bb103cdf1e2611fa9cc9955ee943a6
https://doi.org/10.3389/fmicb.2019.02776
https://doi.org/10.3389/fmicb.2019.02776