Characterization of HIV-1 Infection and Innate Sensing in Different Types of Primary Human Monocyte-Derived Macrophages

Autor: Elisabeth A. Diget, Kaja Zuwala, Randi K. Berg, Rune R. Laursen, Stine Søby, Lars Østergaard, Jesper Melchjorsen, Trine H. Mogensen

Publikováno v: Mediators of Inflammation, Vol 2013 (2013)

Macrophages play an important role in human immunodeficiency virus (HIV) pathogenesis and contribute to establishment of a viral reservoir responsible for continuous virus production and virus transmission to T cells. In this study, we investigated t

Externí odkaz: https://doaj.org/article/6d1d2d9709754c578161dd7559a7f417

Detecting mismatched donor HLA types from allograft biopsies – An easily applicable tool for improved individualized risk assessment

Autor: Pernille Koefoed-Nielsen, Maja Nørgaard, Mette Christiansen, Mie Topholm Bruun, Randi K. Berg

Publikováno v: Berg, R, Nørgaard, M, Bruun, M T, Christiansen, M & Koefoed-Nielsen, P 2020, ' Detecting mismatched donor HLA types from allograft biopsies – An easily applicable tool for improved individualized risk assessment ', Human Immunology, vol. 81, no. 7, pp. 337-341 . https://doi.org/10.1016/j.humimm.2020.04.006
Berg, R, Nørgaard, M, Bruun, M T, Christiansen, M & Koefoed-Nielsen, P 2020, ' Detecting mismatched donor HLA types from allograft biopsies : An easily applicable tool for improved individualized risk assessment ', Human Immunology, vol. 81, no. 7, pp. 337-341 . https://doi.org/10.1016/j.humimm.2020.04.006

Short-term allograft survival has improved among solid organ transplant (SOT) patients. An increasing number of SOT patients are prepared for re-transplantation because of chronic allograft failure. Lack of HLA typing or incomplete HLA typing of prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199f2c9ccecc40830709da003a652430
https://portal.findresearcher.sdu.dk/da/publications/8614fb66-ac26-4d11-9de3-ba09b07d46a3

Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates with chronic immune activation

Autor: Martin R. Jakobsen, Søren R. Paludan, Lars Østergaard, Karen Lise Dahl Andersen, Martin Tolstrup, Randi K. Berg, Jesper F Højen, Sara K. Nissen, Emil Kofod-Olsen, Trine H. Mogensen

Publikováno v: Nissen, S K, Højen, J F, Andersen, K L D, Kofod-Olsen, E, Berg, R K, Paludan, S R, Ostergaard, L, Jakobsen, M R, Tolstrup, M & Mogensen, T H 2014, ' Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates to chronic immune activation ', Clinical and Experimental Immunology, vol. 177, no. 1, pp. 295-309 . https://doi.org/10.1111/cei.12317

Summary The innate immune system has been recognized to play a role in the pathogenesis of HIV infection, both by stimulating protective activities and through a contribution to chronic immune activation, the development of immunodeficiency and progr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8043b9369fb33dc7112a1e0211ba80d5
https://doi.org/10.1111/cei.12317

T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication

Autor: Louise B. Jørgensen, Christian K. Holm, Randi K. Berg, Lars Østergaard, Stine H. Rahbek, Carsten Schade Larsen, Trine H. Mogensen, David G. Jensen, Martin R. Jakobsen, Anne Louise Hansen, Martin Tolstrup, Søren R. Paludan, Jesper Melchjorsen, Emil Kofod-Olsen

Publikováno v: PLoS ONE
Berg, R K, Rahbek, S H, Kofod-Olsen, E, Holm, C K, Melchjorsen, J, Jensen, D G, Hansen, A L, Jørgensen, L B, Østergaard, L J, Tolstrup, M, Larsen, C S, Paludan, S R, Jakobsen, M R & Mogensen, T H 2014, ' T Cells Detect Intracellular DNA but Fail to Induce Type I IFN Responses : Implications for Restriction of HIV Replication ', PLOS ONE, vol. 9, no. 1, pp. e84513 . https://doi.org/10.1371/journal.pone.0084513
PLoS ONE, Vol 9, Iss 1, p e84513 (2014)

HIV infects key cell types of the immune system, most notably macrophages and CD4+ T cells. Whereas macrophages represent an important viral reservoir, activated CD4+ T cells are the most permissive cell types supporting high levels of viral replicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7c7baa580ddae1822431cb620e0424
https://pubmed.ncbi.nlm.nih.gov/24404168

Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA

Autor: Johanna Rintahaka, Robert J. Gorelick, Søren R. Paludan, Elisabeth A. Diget, Sampsa Matikainen, Jesper Melchjorsen, Lars Østergaard, Kristy A. Horan, Stine Søby, Randi K. Berg, Carsten Schade Larsen, Trine H. Mogensen

Publikováno v: PLoS One, 7
PLoS ONE
PLoS ONE, Vol 7, Iss 1, p e29291 (2012)
PLoS One, 7, 1
Berg, R K, Melchjorsen, J, Rintahaka, J, Diget, E, Søby, S, Horan, K A, Gorelick, R J, Matikainen, S, Larsen, C S, Østergaard, L J, Paludan, S R & Mogensen, T H 2012, ' Genomic HIV RNA Induces Innate Immune Responses through RIG-I-Dependent Sensing of Secondary-Structured RNA ', P L o S One, vol. 7, no. 1, pp. e29291 . https://doi.org/10.1371/journal.pone.0029291

Contains fulltext : 108031.pdf (Publisher’s version ) (Open Access) BACKGROUND: Innate immune responses have recently been appreciated to play an important role in the pathogenesis of HIV infection. Whereas inadequate innate immune sensing of HIV d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb20e28d139729c61fcff04e288c53c
https://doi.org/10.1371/journal.pone.0029291