Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Randi Isenhart"'
Autor:
Jon C. Aster, Noori Sotudeh, Jens G. Lohr, David T. Teachey, Guangwu Guo, Monica S. Nair, Tushara Vijaykumar, Praveen Anand, Huiyoung Yun, Anna Jollyette Rogers, Daniel J. DeAngelo, Yotam Drier, Andrew E. Place, Sayalee Potdar, Julia Frede, Tiffaney Vincent, Andrew A. Lane, Madhu M. Ouseph, Amy Guillaumet-Adkins, Jake A. Kloeber, Randi Isenhart, Lewis B. Silverman, Bradley E. Bernstein, Leili Niu, Marian H. Harris, Birgit Knoechel, Valeriya Dimitrova
Publikováno v:
Blood
Lineage plasticity and stemness have been invoked as causes of therapy resistance in cancer, because these flexible states allow cancer cells to dedifferentiate and alter their dependencies. We investigated such resistance mechanisms in relapsed/refr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534bfa5be53f9fc4ffd3aba42f3a93f4
https://doi.org/10.1182/blood.2019004547
https://doi.org/10.1182/blood.2019004547
Autor:
Daniel S. Park, Son C. Nguyen, Randi Isenhart, Parisha P. Shah, Wonho Kim, R. Jordan Barnett, Aditi Chandra, Jennifer M. Luppino, Jailynn Harke, May Wai, Rachel Yang, Yemin Lan, Sora Yoon, Rebecca Yunker, Golnaz Vahedi, Jennifer E. Phillips-Cremins, Rajan Jain, Eric F. Joyce
SummaryAlthough the molecular rules governing genome organization are being quickly elucidated, relatively few proteins regulating this process have been identified. To address this gap, we developed a fully automated imaging pipeline, called HiDRO (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab6e2e8b1880b902b4232e78005c0e37
https://doi.org/10.1101/2022.04.08.487672
https://doi.org/10.1101/2022.04.08.487672
Autor:
Tushara Vijaykumar, Antonis Kokkalis, Kenneth C. Anderson, Birgit Knoechel, Gavin Ha, Charles Seifer, Nikhil C. Munshi, Paul G. Richardson, Noopur Raje, Jordan Voisine, Valeriya Dimitrova, Guangwu Guo, Diane Warren, Jacob P. Laubach, Yu-Tzu Tai, Randi Isenhart, Jake A. Kloeber, Andrew Yee, Elizabeth O'Donnell, Matthew Meyerson, Giada Bianchi, Julia Frede, Huiyoung Yun, Jens G. Lohr, Erica Gemme
Publikováno v:
Leukemia. 32:1838-1841
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28340a0613d2968d8c986a178f21e4f9
https://doi.org/10.1038/s41375-018-0115-z
https://doi.org/10.1038/s41375-018-0115-z
Autor:
Melissa A. Burns, Pieter Van Vlierberghe, Lewis B. Silverman, Karen R. Rabin, Donna Neuberg, Kimberly Bodaar, Randi Isenhart, Salmaan Karim, Birgit Knoechel, Meenakshi Devidas, Stuart H. Orkin, Björn Menten, Alejandro Gutierrez, Triona Ni Chonghaile, James Degar, Kristen E. Stevenson, Ingrid M. Ariës, Kimberly P. Dunsmore, Sofie Peirs, Sebastian T. Balbach, Jack T Landrigan, Stephen E. Sallan, Mignon L. Loh, Laura Hinze, Anthony Letai, Maren Pfirrmann, Brent L. Wood, David T. Teachey, Stuart S. Winter, Stephen P. Hunger
Publikováno v:
The Journal of Experimental Medicine
JOURNAL OF EXPERIMENTAL MEDICINE
The Journal of experimental medicine, vol 215, iss 12
JOURNAL OF EXPERIMENTAL MEDICINE
The Journal of experimental medicine, vol 215, iss 12
Mitochondrial apoptotic priming predicts response to cancer chemotherapy, but the mechanisms underlying variability in this mitochondrial phenotype among closely related tumors are poorly understood. Ariës et al. show that PRC2 loss-of-function muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b1008118d65ee601a642016f1a55a5
http://europepmc.org/articles/PMC6279404
http://europepmc.org/articles/PMC6279404
Autor:
Lewis B. Silverman, Madhu M. Ouseph, Amy Guillaumet-Adkins, Huiyoung Yun, Anna Jollyette Rogers, Andrew A. Lane, Jake A. Kloeber, Sayalee Potdar, Bradley E. Bernstein, Praveen Anand, Julia Frede, Birgit Knoechel, Jens G. Lohr, Yotam Drier, Marian H. Harris, Monica S. Nair, Guangwu Guo, Tushara Vijaykumar, Jon C. Aster, Daniel J. DeAngelo, Randi Isenhart
Publikováno v:
Blood. 134:3953-3953
Introduction: Early T-cell precursor acute lymphoblastic leukemia (ETP T-ALL) is a distinct subtype of T-ALL characterized by higher rates of relapse and induction failure. Large-scale genetic sequencing studies have identified frequently mutated onc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec6fc450434165ab21fae6372d3bb195
https://doi.org/10.1182/blood-2019-130482
https://doi.org/10.1182/blood-2019-130482
Autor:
Eric Still, Tatyana Gindin, Michael G. Kharas, Fiona C. Brown, Richard Koche, Andrei V. Krivtsov, Elisa de Stanchina, Lauren Forbes, Kavitha Ramaswamy, Alex Kentsis, Birgit Knoechel, Gerard Minuesa, Scott A. Armstrong, Randi Isenhart, Guangwu Guo
Publikováno v:
Blood. 128:3945-3945
Aberrant gene expression is a hallmark of acute leukemias. However, therapeutic strategies for its blockade are generally lacking, in large part due to the pharmacologic challenges of drugging transcription factors. MYB-driven gene trans-activation w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33b25043b3a7f6e2678d3a35448d6317
https://doi.org/10.1182/blood.v128.22.3945.3945
https://doi.org/10.1182/blood.v128.22.3945.3945