Výsledky vyhledávání - "Randi Gussgard Syljuåsen"

Akademický článek

TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency.

Autor: Kristine Lillebø Holm, Randi Gussgard Syljuåsen, Grete Hasvold, Lene Alsøe, Hilde Nilsen, Kristina Ivanauskiene, Philippe Collas, Sergey Shaposhnikov, Andrew Collins, Randi Larsen Indrevær, Pål Aukrust, Børre Fevang, Heidi Kiil Blomhoff

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0185708 (2017)

In the present study, we address the important issue of whether B-cells protected from irradiation-induced cell death, may survive with elevated levels of DNA damage. If so, such cells would be at higher risk of gaining mutations and undergoing malig

Externí odkaz: https://doaj.org/article/eb13dd317a9b438e905249db795dd9db

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Akademický článek

Targeting lung cancer through inhibition of checkpoint kinases

Autor: Randi Gussgard Syljuåsen, Grete eHasvold, Sissel eHauge, Åslaug eHelland

Publikováno v: Frontiers in Genetics, Vol 6 (2015)

Inhibitors of checkpoint kinases ATR, Chk1 and Wee1 are currently being tested in preclinical and clinical trials. Here, we review the basic principles behind the use of such inhibitors as anticancer agents, and particularly discuss their potential f

Externí odkaz: https://doaj.org/article/696f9b3b53fd4c9ca8b001371196a639

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