Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Randi G Syljuåsen"'
Autor:
Gro Elise Rødland, Mihaela Temelie, Adrian Eek Mariampillai, Sissel Hauge, Antoine Gilbert, François Chevalier, Diana I. Savu, Randi G. Syljuåsen
Publikováno v:
Cells, Vol 13, Iss 12, p 1058 (2024)
The use of charged particle radiotherapy is currently increasing, but combination therapy with DNA repair inhibitors remains to be exploited in the clinic. The high-linear energy transfer (LET) radiation delivered by charged particles causes clustere
Externí odkaz:
https://doaj.org/article/3e2a93a5c17c4689810716fd9c5f3a83
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionInhibitors of the ATR kinase act as radiosensitizers through abrogating the G2 checkpoint and reducing DNA repair. Recent studies suggest that ATR inhibitors can also increase radiation-induced antitumor immunity, but the underlying immun
Externí odkaz:
https://doaj.org/article/0de3999ef1b046779384745bf5c9e9aa
Autor:
Adrian Eek Mariampillai, Sissel Hauge, Inger Øynebråten, Gro Elise Rødland, Alexandre Corthay, Randi G. Syljuåsen
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Recent studies suggest that inhibition of the ATR kinase can potentiate radiation-induced antitumor immune responses, but the extent and mechanisms of such responses in human cancers remain scarcely understood. We aimed to assess whether the ATR inhi
Externí odkaz:
https://doaj.org/article/7fea646455fc4b5b8ee5d1fb69887e1b
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 3 (2021)
Conflicts between transcription and replication are a major source of replication stress. Our recent findings show that proper dephosphorylation of Serine 5 in the carboxy-terminal domain (CTD) of DNA-directed RNA polymerase II subunit RPB1 is needed
Externí odkaz:
https://doaj.org/article/d28418e2d53a486caeea1ac2f67f4857
Autor:
Helga B. Landsverk, Lise E. Sandquist, Lilli T.E. Bay, Barbara Steurer, Coen Campsteijn, Ole J.B. Landsverk, Jurgen A. Marteijn, Eva Petermann, Laura Trinkle-Mulcahy, Randi G. Syljuåsen
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108469- (2020)
Summary: Transcription-replication (T-R) conflicts cause replication stress and loss of genome integrity. However, the transcription-related processes that restrain such conflicts are poorly understood. Here, we demonstrate that the RNA polymerase II
Externí odkaz:
https://doaj.org/article/d88cff54f29d4bef9a68867c7e0033c3
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Checkpoint kinases are important in cellular surveillance pathways that help cells to cope with DNA damage and protect their genomes. In cycling cells, DNA replication is one of the most sensitive processes and therefore all organisms carefu
Externí odkaz:
https://doaj.org/article/9e8ac8dcb38b4280adc4d709977a6bdc
Autor:
Gro Elise Rødland, Katrine Melhus, Roman Generalov, Sania Gilani, Francesco Bertoni, Jostein Dahle, Randi G. Syljuåsen, Sebastian Patzke
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
The CD37 targeting radioimmunoconjugate 177Lu-lilotomab satetraxetan (Betalutin) is currently being evaluated in a clinical phase 2b trial for patients with follicular lymphoma (FL) and in a phase 1 trial for patients with diffuse large B-cell lympho
Externí odkaz:
https://doaj.org/article/f42a13b7d73f4b2e8332fd0c874cc7f7
Autor:
Randi G. Syljuåsen, Einar K. Rofstad, Kinga Tkacz-Stachowska, Viola Nähse-Kumpf, Grete Hasvold
PDF - 491K, Supplementary Figure S1: Cell cycle progression following hypoxia treatment. Supplementary Figure S2: Clonogenic survival following depletion of CHK1 by siRNA transfection. Supplementary Figure S3: S phase damage in HCT116p53-/- and HT29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851723fd69fb19c9d51f32e5da1f3f39
https://doi.org/10.1158/1535-7163.22497537.v1
https://doi.org/10.1158/1535-7163.22497537.v1
Autor:
Randi G. Syljuåsen, Einar K. Rofstad, Kinga Tkacz-Stachowska, Viola Nähse-Kumpf, Grete Hasvold
Inhibitors of CHK1 are in clinical trials for cancer treatment in combination with DNA-damaging agents. Importantly, it was previously suggested that hypoxic cancer cells may be particularly sensitive to CHK1 inhibition. However, this suggestion was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5853574abc1174612c31dc42c0345299
https://doi.org/10.1158/1535-7163.c.6535647.v1
https://doi.org/10.1158/1535-7163.c.6535647.v1