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4-Phenylbutyrate promoted wild-type γ-aminobutyric acid type A receptor trafficking, reduced endoplasmic reticulum stress, and mitigated seizures in Gabrg2 ^+/Q390X mice associated with Dravet syndrome.

Autor: Shen W; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Flamm C; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Delahanty AJ; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Casteel E; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Biven M; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., DeLeeuw MB; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College, Nashville, Tennessee, USA., Poliquin S; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Nwosu G; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Randhave K; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Kang JQ; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College, Nashville, Tennessee, USA.; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Publikováno v: Epilepsia [Epilepsia] 2024 Jan; Vol. 65 (1), pp. 204-217. Date of Electronic Publication: 2023 Nov 29.