Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Randall W. Steinkampf"'
Autor:
Wayne Klohs, Denise L. Driscoll, Aneesa M. Amar, Wilbur R. Leopold, H. D. Hollis Showalter, Brian G. Hartl, William L. Elliott, Bill J. Roberts, Stacey L. Boushelle, Andrew M. Thompson, Randall W. Steinkampf, Connolly Cleo, Patrick W. Vincent, William A. Denny, James M. Hamby, Sandra J. Patmore, Alan J. Kraker
Publikováno v:
Journal of Medicinal Chemistry. 43:4200-4211
A series of 3-aryl-1,6-naphthyridine-2,7-diamines and related 2-ureas were prepared and evaluated as inhibitors of the FGF receptor-1 tyrosine kinase. Condensation of 4,6-diaminonicotinaldehyde and substituted phenylacetonitriles gave intermediate na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07718491fc8ec80795a8cc02f1071ca
https://doi.org/10.1021/jm000161d
https://doi.org/10.1021/jm000161d
Autor:
Jean Veith, Barbara W. Henderson, Mel C. Schroeder, Adam B. Sumlin, Denise Driscoll, Paula J. Pera, Wayne D. Klohs, Amarnath Sharma, Sylvester Klutchko, Charles J. Dimitroff, Randall W. Steinkampf, Ralph J. Bernacki, Thomas J. Dougherty
Publikováno v:
Investigational New Drugs. 17:121-135
Angiogenesis, the formation of new blood vessels from an existing vasculature, is requisite for tumor growth. It entails intercellular coordination of endothelial and tumor cells through angiogenic growth factor signaling. Interruption of these event
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d846089d48c21d015fa42fc8351a5790
https://doi.org/10.1023/a:1006367032156
https://doi.org/10.1023/a:1006367032156
Publikováno v:
European Journal of Cancer. 32:311-315
Stout and colleagues [ Proc Am Assoc Cancer Res 1993, 34, p. 298] previously reported that both hydrocortisone and tamoxifen increased the free fraction of suramin in human plasma. We examined several corticosteroids as well as tamoxifen for their ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7c95597135ab745124fd73fd854699
https://doi.org/10.1016/0959-8049(95)00543-9
https://doi.org/10.1016/0959-8049(95)00543-9
Publikováno v:
International Journal of Cancer. 62:636-642
The mechanism of action of the novel anti-cancer compound CI-994 was studied in C26 murine colon tumor and HCT-8 human colon adenocarcinoma cells. Treatment of either cell line resulted in the specific loss of a 16-kDa phosphoprotein in a time- and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe346631e6f7047b925d8cb52ac4aee
https://doi.org/10.1002/ijc.2910620524
https://doi.org/10.1002/ijc.2910620524
Autor:
William A. Denny, Alan J. Kraker, Jeff B. Smaill, Gordon W. Rewcastle, Brian D. Palmer, Ellen Myra Dobrusin, Randall W. Steinkampf, Charles W. Moore
Publikováno v:
ChemInform. 36
A series of 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones were synthesized and evaluated for their inhibitory properties against the non-receptor kinase c-Src and the G2/M checkpoint kinase Wee1. Overall, the compounds were 10-100-fold more pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc0a13e9be4417dfd5d29f786d075eb
https://doi.org/10.1002/chin.200531189
https://doi.org/10.1002/chin.200531189
Autor:
Patrick W. Vincent, Aneesa M. Amar, Gina H. Lu, Diane H. Boschelli, James M. Nelson, Hussein Hallak, Sylvester Klutchko, Donald J. Dykes, Laura A. Bradford, Panek Rl, Chad L. Stoner, Wayne D. Klohs, James M. Hamby, Brian G. Hartl, H. D. Hollis Showalter, Randall W. Steinkampf, Alan J. Kraker, Annette M. Doherty, Billy J. Roberts, Cynthia Shen, William L. Elliott, Terry C. Major, Tawny K. Dahring, Zhipei Wu, Denise L. Driscoll
Publikováno v:
Journal of medicinal chemistry. 41(17)
While engaged in therapeutic intervention against a number of proliferative diseases, we have discovered the 2-aminopyrido[2, 3-d]pyrimidin-7(8H)-ones as a novel class of potent, broadly active tyrosine kinase (TK) inhibitors. An efficient route was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96247a3000b371a6bbb1cbb03279775
https://pubmed.ncbi.nlm.nih.gov/9703473
https://pubmed.ncbi.nlm.nih.gov/9703473
Evaluation of galactosyltransferase isoenzyme II in a human colon carcinoma-derived cell line, HCT-8
Publikováno v:
European Journal of Cancer and Clinical Oncology. 22:205-210
Polyacrylamide gel electrophoresis of galactosyltransferase (GT) extracted from a human colon adenocarcinoma cell line, HCT-8, demonstrated the presence of two peaks of activity: a slow-moving peak, referred to as GT-II, and a more anodally migrating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1b7cda88cc80d504b15dd580b44215
https://doi.org/10.1016/0277-5379(86)90032-5
https://doi.org/10.1016/0277-5379(86)90032-5
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 33:526-533
The duration of protection from blood-stage malarial challenge following single injections of pyrimethamine pamoate was assessed in mice and monkeys. This duration was dose-related and ranged from several weeks in mice to over 4 months in the monkeys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9efadf270fed259cd6830c784561fb7
https://doi.org/10.4269/ajtmh.1984.33.526
https://doi.org/10.4269/ajtmh.1984.33.526
Autor:
Amie E. Mertus, Randall W. Steinkampf, Josefino B. Tunac, Max S. Wicha, Wilbur R. Leopold, Wayne Daniel Klohs
Publikováno v:
JNCI: Journal of the National Cancer Institute.
Proline analogues such as cis-4-hydroxy-L-proline (CHP) and L-azetidine-2-carboxylic acid (A2C) were tested for their antitumor activity in tissue culture and in vivo. In culture, CHP specifically inhibited those tumor cells that synthesized basement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7736095a73be1e03a26f017650bdb57
https://doi.org/10.1093/jnci/75.2.353
https://doi.org/10.1093/jnci/75.2.353