Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Randall S. Walikonis"'
Autor:
Eli J. Rogers, Reem Jada, Kinneret Schragenheim-Rozales, Megha Sah, Marisol Cortes, Matthew Florence, Nina S. Levy, Rachel Moss, Randall S. Walikonis, Raz Palty, Reut Shalgi, Daniela Lichtman, Alexandra Kavushansky, Nashaat Z. Gerges, Itamar Kahn, George K. E. Umanah, Andrew P. Levy
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
We have recently described an A350V mutation in IQSEC2 associated with intellectual disability, autism and epilepsy. We sought to understand the molecular pathophysiology of this mutation with the goal of developing targets for drug intervention. We
Externí odkaz:
https://doaj.org/article/14ef286995ec4aa7b07fafd45f233f65
Autor:
Joshua C. Brown, Amber Petersen, Ling Zhong, Miranda L. Himelright, Jessica A. Murphy, Randall S. Walikonis, Nashaat Z. Gerges
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
BRAG1 mutations are linked to synaptic deficits and X-chromosome linked intellectual disability. Here, the authors show that BRAG1 mediates activity-dependent removal of synaptic AMPA receptors via Arf-GEF activity and PDZ interactions, and is requir
Externí odkaz:
https://doaj.org/article/e7365a0bc59244df82f32d08406fd3db
Autor:
Shaun S Sanders, Luiselys M Hernandez, Heun Soh, Santi Karnam, Randall S Walikonis, Anastasios V Tzingounis, Gareth M Thomas
Publikováno v:
eLife, Vol 9 (2020)
The palmitoyl acyltransferase (PAT) ZDHHC14 is highly expressed in the hippocampus and is the only PAT predicted to bind Type-I PDZ domain-containing proteins. However, ZDHHC14’s neuronal roles are unknown. Here, we identify the PDZ domain-containi
Externí odkaz:
https://doaj.org/article/3bf2d48f0eda4e9999d27548f27e9678
Autor:
Randall S. Walikonis, Chilman Bae, Wenjuan Ru, Yuqiang Shi, Xin Liu, Shao Jun Tang, Jin Mo Chung
HIV-1 infection of the nervous system causes various neurological diseases, and synaptic degeneration is likely a critical step in the neuropathogenesis. Our prior studies revealed a significant decrease of synaptic protein, specifically in the spina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e323bc300cd7e9aa27c7a618eb30867
https://europepmc.org/articles/PMC6794928/
https://europepmc.org/articles/PMC6794928/
Autor:
Nashaat Z. Gerges, Reem Jada, Reut Shalgi, Megha Sah, Eli Rogers, Daniela Lichtman, Rachel E. Moss, Matthew A. Florence, George K.E. Umanah, Marisol Cortes, Nina S. Levy, Itamar Kahn, Alexandra Kavushansky, Randall S. Walikonis, Raz Palty, Kinneret Schragenheim-Rozales, Andrew P. Levy
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
We have recently described an A350V mutation in IQSEC2 associated with intellectual disability, autism and epilepsy. We sought to understand the molecular pathophysiology of this mutation with the goal of developing targets for drug intervention. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0d65d0d22f1ef8080c99a6e373c0e2
https://doi.org/10.3389/fnmol.2019.00043
https://doi.org/10.3389/fnmol.2019.00043
Autor:
George Lykotrafitis, Megha Sah, Anastasios V. Tzingounis, Randall S. Walikonis, Krithika Abiraman
Publikováno v:
Journal of Molecular Biology. 428:2521-2537
Small-conductance calcium-activated potassium (SK) channels mediate a potassium conductance in the brain and are involved in synaptic plasticity, learning, and memory. SK channels show a distinct subcellular localization that is crucial for their neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f00815c3275b25eb01ee9c29d5c703
https://doi.org/10.1016/j.jmb.2016.04.014
https://doi.org/10.1016/j.jmb.2016.04.014
Autor:
Jamie L. Maciaszek, Randall S. Walikonis, Heun Soh, George Lykotrafitis, Anastasios V. Tzingounis
Publikováno v:
The Journal of Neuroscience. 32:11435-11440
The spatial distribution of ion channels is an important determinant of neuronal excitability. However, there are currently no quantitative techniques to map endogenous ion channels with single-channel resolution in living cells. Here, we demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1c2ce9f60d6b64252f143df6ab7fed
https://doi.org/10.1523/jneurosci.1785-12.2012
https://doi.org/10.1523/jneurosci.1785-12.2012
Autor:
Sun-Jung Cho, Samikshan Dutta, HyunSook Lee, Jinyoung Song, Il Soo Moon, Randall S. Walikonis
Publikováno v:
Molecules and Cells. 32:89-98
Septins, a conserved family of GTP-binding proteins with a conserved role in cytokinesis, are present in eukaryotes ranging from yeast to mammals. Septins are also highly expressed in neurons, which are post-mitotic cells. Septin6 (SEPT6) forms SEPT2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58cd177471b793789d553bf5a51f6e0
https://doi.org/10.1007/s10059-011-1048-9
https://doi.org/10.1007/s10059-011-1048-9
Autor:
Chol Seung Lim, Randall S. Walikonis
Publikováno v:
Cellular Signalling. 20:825-835
During central nervous system development, growth factors and their associated receptor protein tyrosine kinases regulate many neuronal functions such as neurite extension and dendrite maturation. Hepatocyte growth factor (HGF) and its receptor, c-Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9877c9014f9d03a48b79030765e99558
https://doi.org/10.1016/j.cellsig.2007.12.013
https://doi.org/10.1016/j.cellsig.2007.12.013