Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Randall S. Frey"'
Publikováno v:
Antioxidants & Redox Signaling. 11:791-810
Reactive oxygen species (ROS) including superoxide (O2·−) and hydrogen peroxide (H2O2) are produced endogenously in response to cytokines, growth factors; G-protein coupled receptors, and shear stress in endothelial cells (ECs). ROS function as si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5b96b61a322ef6498e89985510a924
https://doi.org/10.1089/ars.2008.2220
https://doi.org/10.1089/ars.2008.2220
Publikováno v:
Journal of Biological Chemistry. 282:6116-6125
We examined the role of class IA phosphoinositide 3-kinase (PI3K) in the regulation of activation of NADPH oxidase in PMNs and the mechanism of PMN-dependent lung inflammation and microvessel injury induced by the pro-inflammatory cytokine TNF-alpha.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::439a46693aa47e35e429f86326de83bc
https://doi.org/10.1074/jbc.m610248200
https://doi.org/10.1074/jbc.m610248200
Autor:
Vladimir V. Kalinichenko, Muhammad K. Mirza, Yidan D. Zhao, I-Ching Wang, Robert H. Costa, You Yang Zhao, Asrar B. Malik, Xiaopei Gao, Randall S. Frey
Publikováno v:
Journal of Clinical Investigation. 116:2333-2343
Recovery of endothelial integrity after vascular injury is vital for endothelial barrier function and vascular homeostasis. However, little is known about the molecular mechanisms of endothelial barrier repair following injury. To investigate the fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96830c5220615712c2e02ee5514c077e
https://doi.org/10.1172/jci27154
https://doi.org/10.1172/jci27154
Publikováno v:
Physiological Genomics. 21:230-242
To inactivate chronically the β2-integrin CD11b (Mac-1), we made a transgenic model in mice in which we expressed the CD11b antagonist polypeptide neutrophil inhibitory factor (NIF). Using these mice, we determined the in vivo effects of CD11b inact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b1242f585a327a7fc71568687e7e61
https://doi.org/10.1152/physiolgenomics.00291.2004
https://doi.org/10.1152/physiolgenomics.00291.2004
Autor:
Qinghui Liu, Xiao Pei Gao, Asrar B. Malik, Jie Fan, Randall S. Frey, Ximing Zhou, Khandaker N. Anwar
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 288:L655-L662
We identify herein a novel signaling function of the Toll-like receptor-4 (TLR4), the lipopolysaccharide (LPS) receptor mediating the innate immune response, in inducing the expression of CD11b/CD18 integrin in polymorphonuclear leukocytes (PMNs). St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686ab96aab807196dc0b8089e6306a15
https://doi.org/10.1152/ajplung.00327.2004
https://doi.org/10.1152/ajplung.00327.2004
Publikováno v:
Circulation Research. 90:1012-1019
Although oxidant generation by NADPH oxidase is known to play an important role in signaling in endothelial cells, the basis of activation of NADPH oxidase is incompletely understood. The atypical isoform of protein kinase C, PKCζ, has been implicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f443ab56133c7db5dc7390dca7101f7c
https://doi.org/10.1161/01.res.0000017631.28815.8e
https://doi.org/10.1161/01.res.0000017631.28815.8e
Publikováno v:
Journal of Biological Chemistry. 277:3404-3411
In this study, we explored a novel function of polymorphonuclear neutrophils (PMN) NAD(P)H oxidase in the mechanism of tumor necrosis factor-alpha (TNFalpha)-induced NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164fdb43bc154501bae21f7d7f62a8b3
https://doi.org/10.1074/jbc.m110054200
https://doi.org/10.1074/jbc.m110054200
Publikováno v:
Pharmaceutical Biology. 40:35-42
Phytoestrogens present in legumes and other plants have been the subject of considerable attention due to their reported beneficial impact on chronic diseases, including breast cancer. Recently, it has been reported that normal human mammary epitheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa11fdd0add264dafbcf2e08f4592172
https://doi.org/10.1076/phbi.40.7.35.9176
https://doi.org/10.1076/phbi.40.7.35.9176
Publikováno v:
Cancer Letters. 165:131-137
There is substantial epidemiological evidence suggesting that alcohol consumption is associated with increased risk for breast cancer. However, possible biological mechanisms have not been clearly established. In the present studies, a direct effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fa0621f5e3741bd9ca2d8d4c69a6d1
https://doi.org/10.1016/s0304-3835(01)00419-0
https://doi.org/10.1016/s0304-3835(01)00419-0
Publikováno v:
Oncogene. 18:2033-2037
Our previous data demonstrated that Ras activation was necessary and sufficient for transforming growth factor-beta (TGFbeta)-mediated Erk1 activation, and was required for TGFbeta up-regulation of the Cdk inhibitors (CKI's) p27(Kip1) and p21(Cip1) (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d173172427bed11f0a64acf723c1c33
https://doi.org/10.1038/sj.onc.1202521
https://doi.org/10.1038/sj.onc.1202521