Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Randall S. Carpenter"'
Autor:
Randall S. Carpenter, Jessica M. Marbourg, Faith H. Brennan, Katherine A. Mifflin, Jodie C. E. Hall, Roselyn R. Jiang, Xiaokui M. Mo, Malith Karunasiri, Matthew H. Burke, Adrienne M. Dorrance, Phillip G. Popovich
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Spinal cord injury (SCI) often leads to immune dysfunction, but mechanistic insights are still lacking. Here the authors show that SCI alters chemokine signaling and induces long, persisting defects in hematopoietic stem and progenitor cell migration
Externí odkaz:
https://doaj.org/article/0d1de6f876b2431485cb553f43443b20
Autor:
Faith H. Brennan, Phillip G. Popovich, Jessica M. Marbourg, Katherine A. Mifflin, Adrienne M. Dorrance, Xiaokui M. Mo, Randall S. Carpenter, Matthew H. Burke, Roselyn R. Jiang, Jodie C. E. Hall, Malith Karunasiri
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Spinal cord injury (SCI) causes immune dysfunction, increasing the risk of infectious morbidity and mortality. Since bone marrow hematopoiesis is essential for proper immune function, we hypothesize that SCI disrupts bone marrow hematopoiesis. Indeed
Autor:
Phillip G. Popovich, Manoj K. Gottipati, Faith H. Brennan, Stefan Niewiesk, Randall S. Carpenter, Jodie C. E. Hall, Roselyn R. Jiang
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Humanized mice can be used to better understand how the human immune system responds to central nervous system (CNS) injury and inflammation. The optimal parameters for using humanized mice in preclinical CNS injury models need to be established for
Autor:
Peter H. King, Cyrus L. Hinkson, Tania Rebeiz, William Lin, Agnieszka Ardelt, An Zhang, Randall S. Carpenter, Ewa M. Kosciuczuk, Sydney Reitz, Ifeanyi Iwuchukwu
Publikováno v:
Data in Brief, Vol 16, Iss, Pp 1083-1090 (2018)
Data in Brief
Data in Brief
This set of experiments characterizes a model of transient cerebral ischemic stroke in a transgenic (Tg) mouse line in which the glial fibrillary acidic protein (GFAP) promoter is utilized to drive expression of a human RNA-binding protein, HuR. Addi
Autor:
Sydney Reitz, Agnieszka Ardelt, Tania Rebeiz, Ifeanyi Iwuchukwu, An Zhang, William Lin, Peter H. King, Randall S. Carpenter, Cyrus L. Hinkson, Ewa M. Kosciuczuk
Publikováno v:
Neuroscience Letters. 661:126-131
Background and purpose Ischemic stroke produces significant morbidity and mortality, and acute interventions are limited by short therapeutic windows. Novel approaches to neuroprotection and neurorepair are necessary. HuR is an RNA-binding protein (R
Autor:
Phillip G. Popovich, Devra Huey, Randall S. Carpenter, Kristina A. Kigerl, Jessica M. Marbourg, Stefan Niewiesk, Andrew D. Gaudet
Publikováno v:
Experimental Neurology. 271:432-444
Mouse models have provided key insight into the cellular and molecular control of human immune system function. However, recent data indicate that extrapolating the functional capabilities of the murine immune system into humans can be misleading. Si
Autor:
An Zhang, Sydney Reitz, Martin M. Pike, Agnieszka Ardelt, Cyrus L. Hinkson, Ifeanyi Iwuchukwu, Ayaka Kukino, Randall S. Carpenter, Wonhee Lee
Publikováno v:
Brain research. 1639
Estrogens have previously been shown to protect the brain against acute ischemic insults, by potentially augmenting cerebrovascular function after ischemic stroke. The current study hypothesized that treatment with sustained release of high-dose 17β
Publikováno v:
Stroke. 43
Introduction: Stroke is a serious neurological disorder that affects more than 800,000 Americans each year. HuR, an mRNA binding protein, regulates gene expression by modulating the stability and translational efficiency of mRNAs containing adenine-u
Autor:
Merryl R. Lobo, Huadong Zeng, Agnieszka Ardelt, Piotr Kulesza, An Zhang, Rajanikant B. Solanki, Randall S. Carpenter, Martin M. Pike
Publikováno v:
Brain research. 1461
We previously observed that 17β-estradiol (E2) augments ischemic borderzone vascular density 10 days after focal cerebral ischemia–reperfusion in rats. We now evaluated the effect of E2 on vascular remodeling, lesional characteristics, and motor r