Výsledky vyhledávání - "Randall M, Stevens"

Apremilast for Behçet’s Syndrome — A Phase 2, Placebo-Controlled Study

Autor: Peter A. Merkel, Randall M. Stevens, Lilia Pineda, Ziqi Liu, Yusuf Yazici, Kenneth T. Calamia, Gulen Hatemi, Melike Melikoglu, Cengiz Korkmaz, Cem Mat, Hasan Yazici, Recep Tunc, Banu Turgut Ozturk

Publikováno v: New England Journal of Medicine. 372:1510-1518

Oral ulcers, the hallmark of Behçet's syndrome, can be resistant to conventional treatment; therefore, alternative agents are needed. Apremilast is an oral phosphodiesterase-4 inhibitor that modulates several inflammatory pathways.We conducted a pha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df26c9d3e42685cde99e766e8c762acb
https://doi.org/10.1056/nejmoa1408684

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Current Status, Goals, and Research Agenda for Outcome Measures Development in Behcet Syndrome: Report from OMERACT 2014

Autor: Yesim Ozguler, Virna Levi, Hasan Yazici, Randall M. Stevens, H. Direskeneli, Ozlem Sertel-Berk, Gulen Hatemi, Alfred Mahr, Ahmet Gül, Gonca Mumcu, Peter A. Merkel, Sibel Zehra Aydin

Objective.There is an unmet need for reliable, validated, and widely accepted outcomes and outcome measures for use in clinical trials in Behçet syndrome (BS). Our report summarizes initial steps taken by the Outcome Measures in Rheumatology (OMERAC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e840542be1f034e3c1d55e34572c40
https://hdl.handle.net/11424/246002

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Efficacy of B-Cell–Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis

Autor: Jacek Szechiński, Leszek Szczepanski, Anna Filipowicz-Sosnowska, D. Close, Paul Emery, Jonathan C. W. Edwards, Randall M Stevens, T. Shaw

Publikováno v: New England Journal of Medicine. 350:2572-2581

An open-label study indicated that selective depletion of B cells with the use of rituximab led to sustained clinical improvements for patients with rheumatoid arthritis. To confirm these observations, we conducted a randomized, double-blind, control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70664f867ea1db943b3e21ae1ff0b59
https://doi.org/10.1056/nejmoa032534

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Intravenous human recombinant tumor necrosis factor receptor p55-Fc IgG1 fusion protein, Ro 45-2081 (lenercept): results of a dose-finding study in rheumatoid arthritis

Autor: Daniel E, Furst, Michael, Weisman, Harold E, Paulus, Kenneth, Bulpitt, Michael, Weinblatt, Richard, Polisson, Michel, Zaug, Johannes, Kneer, Philippe, Van der Auwera, Randall M, Stevens

Publikováno v: The Journal of rheumatology. 30(10)

To determine the optimal dose regimen of intravenous (IV) Ro 45-2081 (lenercept), a tumor necrosis factor receptor p55-Fc IgG1 fusion protein, in patients with active rheumatoid arthritis (RA) METHODS: In a double-blind, placebo-controlled, parallel-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c35c0b155964f4765e2f8bcba25372db
https://pubmed.ncbi.nlm.nih.gov/14528504

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Intravenous human recombinant tumor necrosis factor receptor p55-Fc IgG1 fusion protein Ro 45-2081 (lenercept): a double blind, placebo controlled dose-finding study in rheumatoid arthritis

Autor: Rolf, Rau, Oliver, Sander, Piet, van Riel, Leo, van de Putte, Fritz, Hasler, Michel, Zaug, Johannes, Kneer, Philippe, van der Auwera, Randall M, Stevens

Publikováno v: The Journal of rheumatology. 30(4)

To determine the optimal dose regimen for intravenous Ro 45-2081 (lenercept) in patients with rheumatoid arthritis (RA) by evaluating efficacy, safety, tolerability, and pharmacokinetic and pharmacodynamic characteristics.Adult patients with longstan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::644176c774d5ee8523353828edd502af
https://pubmed.ncbi.nlm.nih.gov/12672184

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Dapsone in rheumatoid arthritis

Autor: Mario Lamothe, Randall M. Stevens, David J. Chang, Leonard H. Sigal

Publikováno v: Seminars in arthritis and rheumatism. 25(6)

Dapsone, a synthetic sulfone with chemical similarities to sulfapyridine, has been used for a number of years to treat leprosy and dermatitis herpetiformis. Recently, a number of prospective, randomized, double-blind trials have shown their success i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a8a326ed201e08d3c3d48e092f82bf
https://pubmed.ncbi.nlm.nih.gov/8792511

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