Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Randall K. Rader"'
Autor:
Tiffany Duffin, Maureen A. Nickols, Barbara B. Chen, Mary Beth Finn, Mark A. Russell, William F. Westlin, Steven L. Settle, Mark L. Boys, Randall K. Rader, Jon A. Klover, Wang Yaping, Thomas D. Penning, Jeffery L. Keene, V. Wayne Engleman, G. Allen Nickols, Christina N. Steininger, Sandra K. Freeman, Melanie L. Hanneke, Khilevich Albert, Marisa M. Westlin, Kristen E. Shannon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3156-3161
We describe a series of pyrazole and isoxazole analogs as antagonists of the α v β 3 receptor. Compounds showed low to sub-nanomolar potency against α v β 3 , as well as good selectivity against α IIb β 3 . In HT29 cells, most analogs also demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e27cd8fc7dca2f6785f6b7c08e8bda4
https://doi.org/10.1016/j.bmcl.2006.03.045
https://doi.org/10.1016/j.bmcl.2006.03.045
Autor:
Samuel A. Wickline, Dowdy Jackson, Randall K. Rader, Stasia A. Anderson, John J. Kotyk, Christopher Null, Gregory M. Lanza, William F. Westlin
Publikováno v:
Magnetic Resonance in Medicine. 44:433-439
Site-directed contrast enhancement of angiogenic vessels in vivo was demonstrated using antibody targeting of an MRI contrast agent to the αvβ3 integrin, a molecular marker characteristic of angiogenic endothelium. The agent was tested in a rabbit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88a1900b0f2db4a7455b967780331dec
https://doi.org/10.1002/1522-2594(200009)44:3<433::aid-mrm14>3.0.co
https://doi.org/10.1002/1522-2594(200009)44:3<433::aid-mrm14>3.0.co
Publikováno v:
FEBS Letters. 357:269-274
The influenza A M2 ion channel was expressed and activity characterized in Xenopus oocytes. Based on the activation properties of the channels, a high throughput, non-electrophysiological screening assay was developed in order to identify novel inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1407a20ee84d7c37a6d45502f2ef0cb7
https://doi.org/10.1016/0014-5793(94)01369-c
https://doi.org/10.1016/0014-5793(94)01369-c
Autor:
Vicky Walker Holway, Neetu Venkatraman, Janice M. Thompson, Po-Chang Chiang, Sumathy Mathialagan, Larry E. Kahn, Cynthia D. Sommers, Horng-Chih Huang, Randall K. Rader, Debra M. Meyer, Julia A. Guzova, Debra S. Garner, Sheri L. Bonar, Yiding Hu, George Hu, Nandini Kishore, John F. Schindler
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 330(2)
Nuclear factor-kappaB (NF-kappaB) is one of the major families of transcription factors activated during the inflammatory response in asthma and chronic obstructive pulmonary disease. Inhibitory factor-kappaB kinase 2 (IKK-2) has been shown to play a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c0d9117545548743363e2926d24326
https://pubmed.ncbi.nlm.nih.gov/19478133
https://pubmed.ncbi.nlm.nih.gov/19478133
Autor:
Randall K. Rader, William F. Hood, Thomas H. Lanthorn, Yehiel Gaoni, Gerald B. Watson, Robert P. Compton, Joseph B. Monahan
Publikováno v:
European Journal of Pharmacology. 182:397-404
Cis- and trans-2,4-methanoglutamate were compared with L-glutamate as acidic amino acid ligands. Cis-2,4-methanoglutamate had a Ki of 0.052 microM against N-methyl-D-aspartate (NMDA)-specific L-[3H]glutamate binding compared with 0.050 microM for L-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3093db8168ed4b73c780ac3b662f79f
https://doi.org/10.1016/0014-2999(90)90036-6
https://doi.org/10.1016/0014-2999(90)90036-6
Autor:
Thomas D, Penning, Albert, Khilevich, Barbara B, Chen, Mark A, Russell, Mark L, Boys, Yaping, Wang, Tiffany, Duffin, V Wayne, Engleman, Mary Beth, Finn, Sandra K, Freeman, Melanie L, Hanneke, Jeffery L, Keene, Jon A, Klover, G Allen, Nickols, Maureen A, Nickols, Randall K, Rader, Steven L, Settle, Kristen E, Shannon, Christina N, Steininger, Marisa M, Westlin, William F, Westlin
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(12)
We describe a series of pyrazole and isoxazole analogs as antagonists of the alpha(v)beta3 receptor. Compounds showed low to sub-nanomolar potency against alpha(v)beta3, as well as good selectivity against alpha(IIb)beta3. In HT29 cells, most analogs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b85efae80aa2dd097353fe9524af3756
https://pubmed.ncbi.nlm.nih.gov/16621534
https://pubmed.ncbi.nlm.nih.gov/16621534
Publikováno v:
NMR in biomedicine. 19(1)
MRI methods show great utility for assessing the growth of tumors metastasized to bone in clinical studies. However, preclinical MRI methods in rodents do not translate well to high-throughput studies of bone tumors, especially for early-stage tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e0cdea530e5f9c2404d530af9cfb7e
https://pubmed.ncbi.nlm.nih.gov/16411252
https://pubmed.ncbi.nlm.nih.gov/16411252
Autor:
Robert Melly, Lynn R. Budgeon, Henry J. Donahue, Amy L. Jones, Donna M. Sosnowski, Neil D. Christensen, Geetha R. Babu, Lisa N. Beck, Virginia R. Gilman, Dianalee A. Campo, Michael T. Debies, David W. Griggs, Mark D. Pagel, Julia Kent, Rajeev S. Samant, Andrea M. Mastro, Nuray Erin, Lalita A. Shevde, William J. Meehan, Robin Mercer, John F. Harms, Mary E. Miele, John J. Kotyk, Randall K. Rader, Allen Nickols, William F. Westlin, Jennifer Jewell, Danny R. Welch, Steven F. Goldberg, Gabriel Mbalaviele
Publikováno v:
Clinicalexperimental metastasis. 21(2)
Introduction: Breast cancer is one of the most common malignancies affecting women in the United States and Europe. Approximately three out of every four women with breast cancer develop metastases in bone which, in turn, diminishes quality of life.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db28b005a3e7802243df9738b9312d7c
https://pubmed.ncbi.nlm.nih.gov/15168729
https://pubmed.ncbi.nlm.nih.gov/15168729
Autor:
Randall K. Rader, Jeffrey D. Peterson, Sylvie Kossodo, Thomas P. Misko, Timothy P. LaBranche, John T Listello, Mark A Abrams, Kristine O. Vasquez, Michele A. Melton
Publikováno v:
Arthritis Research & Therapy
Introduction: Standard measurements used to assess murine models of rheumatoid arthritis, notably paw thickness and clinical score, do not align well with certain aspects of disease severity as assessed by histopathology. We tested the hypothesis tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76668a1934be164644b563a5b77de3f
https://doi.org/10.1186/ar3038
https://doi.org/10.1186/ar3038
Publikováno v:
Brain Research. 498:81-88
A large, extracellular negative DC shift, termed epileptic depolarization, could be elicited during zero magnesium-induced epileptic activity in the rat hippocampal slice. In 10 mM glucose medium, epileptic depolarization was elicited by high-frequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fcaef59a78fb905ef7e0d85cdcfc285
https://doi.org/10.1016/0006-8993(89)90401-0
https://doi.org/10.1016/0006-8993(89)90401-0