Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Randall K. Powers"'
Autor:
Y. Curtis Wang, Johann Rudi, James Velasco, Nirvik Sinha, Gideon Idumah, Randall K. Powers, Charles J. Heckman, Matthieu K. Chardon
Publikováno v:
Frontiers in Systems Neuroscience, Vol 16 (2022)
One of the most common types of models that helps us to understand neuron behavior is based on the Hodgkin–Huxley ion channel formulation (HH model). A major challenge with inferring parameters in HH models is non-uniqueness: many different sets of
Externí odkaz:
https://doaj.org/article/417440fe1d7046dc918dcf36357d01c9
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Oscillations in membrane potential induced by synaptic inputs and intrinsic ion channel activity play a role in regulating neuronal excitability, but the precise mechanisms underlying their contributions remain largely unknown. Here we used electroph
Externí odkaz:
https://doaj.org/article/bff3ceb53da04435b404fe3621537bd6
Autor:
Travis M. Rotterman, Darío I. Carrasco, Stephen N. Housley, Paul Nardelli, Randall K. Powers, Timothy C. Cope
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
The axon initial segment (AIS) responsible for action potential initiation is a dynamic structure that varies and changes together with neuronal excitability. Like other neuron types, alpha motoneurons in the mammalian spinal cord express heterogenei
Externí odkaz:
https://doaj.org/article/52ac7e1961b54c428d2e73854a2b8728
Autor:
Matthieu K Chardon, Y Curtis Wang, Marta Garcia, Emre Besler, J Andrew Beauchamp, Michael D'Mello, Randall K Powers, Charles J Heckman
Publikováno v:
eLife, Vol 12 (2024)
In this study, we develop new reverse engineering (RE) techniques to identify the organization of the synaptic inputs generating firing patterns of populations of neurons. We tested these techniques in silico to allow rigorous evaluation of their eff
Externí odkaz:
https://doaj.org/article/dca4fd6afd794d27ba7331811bbcf343
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 1, p e1011487 (2024)
Postinhibitory excitation is a transient overshoot of a neuron's baseline firing rate following an inhibitory stimulus and can be observed in vivo in human motoneurons. However, the biophysical origin of this phenomenon is still unknown and both refl
Externí odkaz:
https://doaj.org/article/59bec7af2f7d4104ad93e26fbef7b7a7
Publikováno v:
Neuroscientist
Both sepsis and treatment of cancer with chemotherapy are known to cause neurologic dysfunction. The primary defects seen in both groups of patients are neuropathy and encephalopathy; the underlying mechanisms are poorly understood. Analysis of precl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab25e69b6bba5337f50493947b322cd
https://pubmed.ncbi.nlm.nih.gov/33345706
https://pubmed.ncbi.nlm.nih.gov/33345706
Autor:
null James A Beauchamp, null Gregory E P Pearcey, null Obaid U Khurram, null Matthieu Chardon, null Y Curtis Wang, null Randall K Powers, null Julius P A Dewald, null C J Heckman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f90bbe0b74411613c24656a7cf90387a
https://doi.org/10.1088/1741-2552/acb1d7/v2/response1
https://doi.org/10.1088/1741-2552/acb1d7/v2/response1
Autor:
Matthieu K. Chardon, Y. Curtis Wang, Marta Garcia, Emre Besler, J. Andrew Beauchamp, Michael D’Mello, Randall K. Powers, Charles J. Heckman
In this study, we achieved a major step forward in the analysis of firing patterns of populations of motoneurons, through remarkably extensive parameter searches enabled by massively-parallel computation on supercomputers. The ability to implement th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3884b8a11f79f24a8d7d63aa59784450
https://doi.org/10.1101/2022.12.09.519818
https://doi.org/10.1101/2022.12.09.519818
Autor:
Y. Curtis Wang, Johann Rudi, James Velasco, Nirvik Sinha, Gideon Idumah, Randall K. Powers, Charles J. Heckman, Matthieu K. Chardon
One of the most common types of models that helps us to understand neuron behavior is based on the Hodgkin–Huxley ion channel formulation (HH model). A major challenge with inferring parameters in HH models is non-uniqueness: many different sets of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a787551bbcb6f3eec140b593853a0e57
https://hdl.handle.net/10919/112831
https://hdl.handle.net/10919/112831
Autor:
James. A. Beauchamp, Gregory E. P. Pearcey, Obaid U. Khurram, Matthieu Chardon, Curtis Wang, Randall K. Powers, Julius P.A. Dewald, CJ. Heckman
ObjectiveAll motor commands flow through motoneurons, which entrain control of their innervated muscle fibers, forming a motor unit (MU). Owing to the high fidelity of action potentials within MUs, their discharge profiles detail the organization of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6145380b6cc1eb7e44c677d5c7812a58
https://doi.org/10.1101/2022.10.06.511149
https://doi.org/10.1101/2022.10.06.511149