Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Randall J. Platt"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Molecular screens comparing different disease states to identify candidate genes rely on the availability of fast, reliable and multiplexable systems to interrogate genes of interest. CRISPR/Cas9-based reverse genetics is a promising method
Externí odkaz:
https://doaj.org/article/7fd74c1a9e8f44f68884782a4b513558
Autor:
Jon M. Madison, Karen Duong, Ellen F. Vieux, Namrata D. Udeshi, Sumaiya Iqbal, Elise Requadt, Shaunt Fereshetian, Michael C. Lewis, Antonio S. Gomes, Kerry A. Pierce, Randall J. Platt, Feng Zhang, Arthur J. Campbell, Dennis Lal, Florence F. Wagner, Clary B. Clish, Steven A. Carr, Morgan Sheng, Edward M. Scolnick, Jeffrey R. Cottrell
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101935- (2021)
Summary: Genetic variation of the 16p11.2 deletion locus containing the KCTD13 gene and of CUL3 is linked with autism. This genetic connection suggested that substrates of a CUL3-KCTD13 ubiquitin ligase may be involved in disease pathogenesis. Compar
Externí odkaz:
https://doaj.org/article/02815da01a7f40da86fd1e72b7901ade
Autor:
Randall J. Platt, Yang Zhou, Ian M. Slaymaker, Ashwin S. Shetty, Niels R. Weisbach, Jin-Ah Kim, Jitendra Sharma, Mitul Desai, Sabina Sood, Hannah R. Kempton, Gerald R. Crabtree, Guoping Feng, Feng Zhang
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 335-350 (2017)
Summary: Autism spectrum disorder (ASD) is a heterogeneous disease, but genetically defined models can provide an entry point to studying the molecular underpinnings of this disorder. We generated germline mutant mice with loss-of-function mutations
Externí odkaz:
https://doaj.org/article/aba3bb6682074342a2b284ec87cc7022
Autor:
Tanmay Tanna, Randall J. Platt
Publikováno v:
Cell Host & Microbe. 31:164-166
Autor:
Nicola Aceto, Randall J. Platt, Timm Schroeder, Claudio Giachino, Verdon Taylor, Christoph Rochlitz, Marcus Vetter, Leo Kunz, Tatjana Vlajnic, Simone Muenst, Zoi Diamantopoulou, Barbara M. Szczerba, Sofia Gkountela, Cinzia Donato, Ramona Scherrer, Aino Paasinen-Sohns, Ilona Krol, Karin Strittmatter, Francesc Castro-Giner, Manuel C. Scheidmann
Blood-borne metastasis of breast cancer involves a series of tightly regulated sequential steps, including the growth of a primary tumor lesion, intravasation of circulating tumor cells (CTC), and adaptation in various distant metastatic sites. The g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d089ec90c9d9d5016ec75589de1da40
https://doi.org/10.1158/0008-5472.c.6513747.v1
https://doi.org/10.1158/0008-5472.c.6513747.v1
Autor:
Nicola Aceto, Randall J. Platt, Timm Schroeder, Claudio Giachino, Verdon Taylor, Christoph Rochlitz, Marcus Vetter, Leo Kunz, Tatjana Vlajnic, Simone Muenst, Zoi Diamantopoulou, Barbara M. Szczerba, Sofia Gkountela, Cinzia Donato, Ramona Scherrer, Aino Paasinen-Sohns, Ilona Krol, Karin Strittmatter, Francesc Castro-Giner, Manuel C. Scheidmann
Supplementary Table from An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ec14b7ae2331fab6c94f7e0174a5bd
https://doi.org/10.1158/0008-5472.22430934.v1
https://doi.org/10.1158/0008-5472.22430934.v1
Autor:
Nicola Aceto, Randall J. Platt, Timm Schroeder, Claudio Giachino, Verdon Taylor, Christoph Rochlitz, Marcus Vetter, Leo Kunz, Tatjana Vlajnic, Simone Muenst, Zoi Diamantopoulou, Barbara M. Szczerba, Sofia Gkountela, Cinzia Donato, Ramona Scherrer, Aino Paasinen-Sohns, Ilona Krol, Karin Strittmatter, Francesc Castro-Giner, Manuel C. Scheidmann
Supplementary Figure from An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176b311f7743882a50f8ba2d1821d135
https://doi.org/10.1158/0008-5472.22430952.v1
https://doi.org/10.1158/0008-5472.22430952.v1
Molecular screens comparing different disease states to identify candidate genes rely on the availability of fast, reliable and multiplexable systems to interrogate genes of interest. CRISPR/Cas9- based reverse genetics is a promising method to event
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f46eb3c5473d74aab27fed6e178686
Autor:
Manuel C. Scheidmann, Francesc Castro-Giner, Karin Strittmatter, Ilona Krol, Aino Paasinen-Sohns, Ramona Scherrer, Cinzia Donato, Sofia Gkountela, Barbara M. Szczerba, Zoi Diamantopoulou, Simone Muenst, Tatjana Vlajnic, Leo Kunz, Marcus Vetter, Christoph Rochlitz, Verdon Taylor, Claudio Giachino, Timm Schroeder, Randall J. Platt, Nicola Aceto
Publikováno v:
Cancer Res
Cancer Research, 82 (4)
Cancer Research, 82 (4)
Blood-borne metastasis of breast cancer involves a series of tightly regulated sequential steps, including the growth of a primary tumor lesion, intravasation of circulating tumor cells (CTC), and adaptation in various distant metastatic sites. The g