Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Randall J. Eck"'
Autor:
Vaishnavi S. Jadhav, Jade G. Stair, Randall J. Eck, Samuel N. Smukowski, Heather N. Currey, Laura Garcia Toscano, Joshua C. Hincks, Caitlin S. Latimer, Paul N. Valdmanis, Brian C. Kraemer, Nicole F. Liachko
Publikováno v:
Neurobiology of Disease, Vol 193, Iss , Pp 106441- (2024)
Alzheimer's disease (AD), the most common aging-associated neurodegenerative dementia disorder, is defined by the presence of amyloid beta (Aβ) and tau aggregates in the brain. However, more than half of patients also exhibit aggregates of the prote
Externí odkaz:
https://doaj.org/article/2d36b23e4d484bf4a6f3f2d1918e850e
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2024)
The nematode Caenorhabditis elegans are a powerful model system to study human disease, with numerous experimental advantages including significant genetic and cellular homology to vertebrate animals, a short lifespan, and tractable behavioral, molec
Externí odkaz:
https://doaj.org/article/b2c4b137fffb423cbccbd3de9ef9b2a5
Autor:
Pamela J. McMillan, Timothy J. Strovas, Misa Baum, Brooke K. Mitchell, Randall J. Eck, Nzinga Hendricks, Jeanna M. Wheeler, Caitlin S. Latimer, C. Dirk Keene, Brian C. Kraemer
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract Several conserved nuclear RNA binding proteins (sut-1, sut-2, and parn-2) control tau aggregation and toxicity in C. elegans, mice, and human cells. MSUT2 protein normally resides in nuclear speckles, membraneless organelles composed of phas
Externí odkaz:
https://doaj.org/article/dd6cabf3bab6402eb83b0235389e890a
Autor:
Erik M. Lehmkuhl, Suvithanandhini Loganathan, Eric Alsop, Alexander D. Blythe, Tina Kovalik, Nicholas P. Mortimore, Dianne Barrameda, Chuol Kueth, Randall J. Eck, Bhavani B. Siddegowda, Archi Joardar, Hannah Ball, Maria E. Macias, Robert Bowser, Kendall Van Keuren-Jensen, Daniela C. Zarnescu
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-21 (2021)
Abstract Amyotrophic lateral sclerosis (ALS) is a genetically heterogeneous neurodegenerative disease in which 97% of patients exhibit cytoplasmic aggregates containing the RNA binding protein TDP-43. Using tagged ribosome affinity purifications in D
Externí odkaz:
https://doaj.org/article/bd7f212aa7f244239b10e60b869cabc4
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2020)
TAR DNA binding protein (TDP-43) is a nucleic acid binding protein associated with insoluble cytoplasmic aggregates in several neurodegenerative disorders, including 97% of the ALS cases. In healthy individuals, TDP-43 is primarily localized to the n
Externí odkaz:
https://doaj.org/article/5460281b79b840e6904568a600df6ecf
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The pathological accumulation of the microtubule binding protein tau drives age-related neurodegeneration in a variety of disorders, collectively called tauopathies. In the most common tauopathy, Alzheimer’s disease (AD), the accumulation of pathol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3fa93fbfcc698a12d5b31af0ad6fe0
https://doi.org/10.1073/pnas.2207250120
https://doi.org/10.1073/pnas.2207250120
Publikováno v:
GeroScience
Insoluble inclusions of phosphorylated TDP-43 occur in disease-affected neurons of most patients with amyotrophic lateral sclerosis (ALS) and about half of patients with frontotemporal lobar degeneration (FTLD-TDP). Phosphorylated TDP-43 potentiates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0793206941e2999591e4e56ce0a7e994
http://europepmc.org/articles/PMC8492835
http://europepmc.org/articles/PMC8492835
Autor:
Brooke K. Mitchell, Randall J. Eck, Timothy J. Strovas, Jeanna M. Wheeler, Misa Baum, Nzinga Hendricks, Caitlin S. Latimer, Brian C. Kraemer, C. Dirk Keene, Pamela J. McMillan
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
Several conserved nuclear RNA binding proteins (sut-1, sut-2, and parn-2) control tau aggregation and toxicity in C. elegans, mice, and human cells. MSUT2 protein normally resides in nuclear speckles, membraneless organelles composed of phase-separat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080d0225ce494f7f8c02ef9a56f81a28
https://pubmed.ncbi.nlm.nih.gov/34187600
https://pubmed.ncbi.nlm.nih.gov/34187600
Autor:
Maria E. Macias, Robert Bowser, Daniela C. Zarnescu, Eric Alsop, Kendall Van Keuren-Jensen, Chuol Kueth, Randall J. Eck, Nicholas P. Mortimore, Suvithanandhini Loganathan, Tina Kovalik, Archi Joardar, Bhavani Bagevalu Siddegowda, Erik M. Lehmkuhl, Hannah Ball, Dianne Barrameda, Alexander D. Blythe
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-21 (2021)
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-21 (2021)
Amyotrophic lateral sclerosis (ALS) is a genetically heterogeneous neurodegenerative disease in which 97% of patients exhibit cytoplasmic aggregates containing the RNA binding protein TDP-43. Using tagged ribosome affinity purifications in Drosophila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308d3f8cd993e313215698fd92900912
https://doi.org/10.1101/2020.07.01.182360
https://doi.org/10.1101/2020.07.01.182360
