Zobrazeno 1 - 10
of 298
pro vyhledávání: '"Randall J, Kimple"'
Autor:
Zafer Gurel, Michael S. Luy, Qianyun Luo, Nicholas L. Arp, Amy K. Erbe, Aparna H. Kesarwala, Jing Fan, Randall J. Kimple
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionLactate is a pivotal molecule with diverse functions in the metabolic reprogramming of cancer cells. Beyond its role in metabolism, lactate exerts a modulatory effect within the tumor microenvironment; it is utilized by stromal cells and
Externí odkaz:
https://doaj.org/article/e11c06729ad144b8b224cd5c1aa245f1
Autor:
Aakarsha Rao, Milan S. Stosic, Chitrasen Mohanty, Dhruthi Suresh, Albert R. Wang, Denis L. Lee, Kwangok P. Nickel, Darshan S. Chandrashekar, Randall J. Kimple, Paul F. Lambert, Christina Kendziorski, Trine B. Rounge, Gopal Iyer
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Human papillomaviruses (HPV), most commonly HPV16, are associated with a subset of head and neck squamous cell carcinoma (HNSCC) tumors, primarily oropharyngeal carcinomas, with integration of viral genomes into host chromosomes associated with worse
Externí odkaz:
https://doaj.org/article/29af87b7f5044f5da49d0afc0c1ed131
Autor:
Albert R. Wang, Andrew M. Baschnagel, Zijian Ni, Sean R. Brennan, Hypatia K. Newton, Darya Buehler, Christina Kendziorski, Randall J. Kimple, Gopal Iyer
Publikováno v:
Genes and Diseases, Vol 11, Iss 3, Pp 101072- (2024)
Externí odkaz:
https://doaj.org/article/f44636bb0393407ab5c28e251bad0023
Autor:
Grace C. Blitzer, Nicole M. Rogus‐Pulia, Cristina Paz, Kwangok P. Nickel, Vanessa L. Cannaday, Cynthia A. Kelm‐Nelson, Sailendharan Sudakaran, Richard J. Chappell, Tiffany Glazer, Randall J. Kimple
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 7, Iss 4, Pp 1018-1024 (2022)
Abstract Objective Radiation therapy (RT) for head and neck cancer (HNC) can result in severe xerostomia, or the subjective feeling of dry mouth. Characterizing xerostomia is critical to designing future clinical trials investigating how to improve H
Externí odkaz:
https://doaj.org/article/73206a9a0e8142a8901e7d44f33b9109
Autor:
Miranda B. Carper, Saumya Goel, Anna M. Zhang, Jeffrey S. Damrauer, Stephanie Cohen, Matthew P. Zimmerman, Gabrielle M. Gentile, Kshitij Parag-Sharma, Ryan M. Murphy, Kotaro Sato, Kwangok P. Nickel, Randall J. Kimple, Wendell G. Yarbrough, Antonio L. Amelio
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 29, Iss , Pp 100799- (2022)
Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide and incidence rates are continuing to rise globally. Patients often present with locally advanced disease and a staggering 50% chance of relapse following treatment
Externí odkaz:
https://doaj.org/article/1f8dd06da4b643fbba1a9c0c8dad07c8
Autor:
Lindsey Abel, Arda Durmaz, Rong Hu, Colin Longhurst, Andrew M. Baschnagel, Deric Wheeler, Jacob G. Scott, Randall J. Kimple
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-8 (2021)
Abstract Background Patient-derived xenografts established from human cancers are important tools for investigating novel anti-cancer therapies. Establishing PDXs requires a significant investment and many PDXs may be used infrequently due to their s
Externí odkaz:
https://doaj.org/article/ba452a720d2d4179be860ac81be2346f
Autor:
Andrew M. Baschnagel, Saakshi Kaushik, Arda Durmaz, Steve Goldstein, Irene M. Ong, Lindsey Abel, Paul A. Clark, Zafer Gurel, Ticiana Leal, Darya Buehler, Gopal Iyer, Jacob G. Scott, Randall J. Kimple
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Non-small cell lung cancer (NSCLC) brain metastasis cell lines and in vivo models are not widely accessible. Herein we report on a direct-from patient-derived xenograft (PDX) model system of NSCLC brain metastases with genomic annotation use
Externí odkaz:
https://doaj.org/article/cf6bf8b2cb75421fa4dbf71ed4ff419a
Autor:
Raghavan Chinnadurai, Paul D. Bates, Keith A. Kunugi, Kwangok P. Nickel, Larry A. DeWerd, Christian M. Capitini, Jacques Galipeau, Randall J. Kimple
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Mesenchymal stromal cells (MSCs) are being tested as a cell therapy in clinical trials for dozens of inflammatory disorders, with varying levels of efficacy reported. Suitable and robust preclinical animal models for testing the safety and efficacy o
Externí odkaz:
https://doaj.org/article/9f6a95f5cd4c45778cceb90c01c5c952
Publikováno v:
BioTechniques, Vol 67, Iss 2, Pp 70-73 (2019)
Quantitative assessment of changes in macro-autophagy is often performed through manual quantification of the number of LC3B foci in immunofluorescence microscopy images. This method is highly laborious, subject to image-field selection and foci-coun
Externí odkaz:
https://doaj.org/article/1481e496358b482a86a0d92e0b3d27e7
Autor:
Maura L. Gillison, Robert L. Ferris, Jonathan Harris, A. Dimitrios Colevas, Loren K. Mell, Christina Kong, Richard C. Jordan, Kevin L. Moore, Minh-Tam Truong, Claudia Kirsch, Arnab Chakravarti, Dukagjin M. Blakaj, David A. Clump, James P. Ohr, John F. Deeken, Michael F. Gensheimer, Nabil F. Saba, Jennifer A. Dorth, David I. Rosenthal, Rom S. Leidner, Randall J. Kimple, Mitchell Machtay, Walter J. Curran, Pedro Torres-Saavedra, Quynh Thu Le
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 115:847-860
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ece44a5b88e2336bcee2b4fbd237a6ee
https://doi.org/10.1016/j.ijrobp.2022.10.008
https://doi.org/10.1016/j.ijrobp.2022.10.008