Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Randall French"'
Autor:
Kathleen M. Scully, Reyhaneh Lahmy, Lia Signaevskaia, Roman Sasik, Rachel Medal, Heejung Kim, Randall French, Brian James, Yifan Wu, Andrew M. Lowy, Pamela Itkin-Ansari
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 2, Pp 181-198 (2018)
Background & Aims: Oncogenic mutations in KRAS, coupled with inactivation of p53, CDKN2A/p16INK4A, and SMAD4, drive progression of pancreatic ductal adenocarcinoma (PDA). Overexpression of MYC and deregulation of retinoblastoma (RB) further promote c
Externí odkaz:
https://doaj.org/article/7aad93be4d8148b1b1f6f1e79e906dae
Autor:
Maya Saison-Ridinger, Kathleen E DelGiorno, Tejia Zhang, Annabelle Kraus, Randall French, Dawn Jaquish, Crystal Tsui, Galina Erikson, Benjamin T Spike, Maxim N Shokhirev, Christopher Liddle, Ruth T Yu, Michael Downes, Ronald M Evans, Alan Saghatelian, Andrew M Lowy, Geoffrey M Wahl
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189051 (2017)
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense fibrotic stroma, which contributes to tumor growth, metastasis, and drug resistance. During tumorigenesis, quiescent pancreatic stellate cells (PSCs) are activated and bec
Externí odkaz:
https://doaj.org/article/23aab20296124703a94f74164e9e8040
Autor:
Kodai Suzuki, Venkata Ramana Kotamraju, Andrew M. Lowy, Gary B. Braun, Tambet Teesalu, Kazuki N. Sugahara, Norio Miyamura, Tatiana Hurtado De Mendoza, Gregory P. Botta, Erkki Ruoslahti, Evangeline Mose, Randall French
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Pancreatic ductal adenocarcinoma (PDAC) is characterized by marked desmoplasia and drug resistance due, in part, to poor drug delivery to extravascular tumor tissue. Here, we report that carcinoma-associated fibroblasts (CAFs) induce β5 integrin exp
Autor:
Jorge I. de la Torre, Andrew M. Lowy, Ronald P. DeMatteo, Mojgan Hosseini, Chih Min Tang, Alfredo A. Molinolo, Randall French, J. Silvio Gutkind, Mengyuan Liu, Lillian R. Klug, Adam M. Burgoyne, Martina De Siena, Sangkyu Noh, Antonio L. Delgado, Mayra Yebra, Hyunho Yoon, Michael Heinrich, Jason K. Sicklick, Zhiyong Wang, Yoon Young Choi, Olivier Harismendy, Sudeep Banerjee
Publikováno v:
Oncogene
Targeted therapies for gastrointestinal stromal tumor (GIST) are modestly effective, but GIST cannot be cured with single agent tyrosine kinase inhibitors. In this study, we sought to identify new therapeutic targets in GIST by investigating the tumo
Publikováno v:
Journal of Visualized Experiments.
Pancreatic ductal adenocarcinoma (PDAC) is amongst the most lethal malignancies. Recently, next-generation organoid culture methods enabling the 3-dimensional (3D) modeling of this disease have been described. Patient-derived organoid (PDO) models ca
Autor:
Pamela Itkin-Ansari, Roman Sasik, Yifan Wu, Reyhaneh Lahmy, Rachel Medal, Randall French, Kathleen M. Scully, Lia Signaevskaia, Brian P. James, Heejung Kim, Andrew M. Lowy
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 2, Pp 181-198 (2018)
Background & Aims: Oncogenic mutations in KRAS, coupled with inactivation of p53, CDKN2A/p16INK4A, and SMAD4, drive progression of pancreatic ductal adenocarcinoma (PDA). Overexpression of MYC and deregulation of retinoblastoma (RB) further promote c
Autor:
Kevin Moyung, Cristina Salmerón, Jordin Marucut, Krishna Sriram, Paul A. Insel, Andrew M. Lowy, Randall French, Shu Z. Wiley, Matthew W. Gorr
Publikováno v:
ACS Omega, Vol 4, Iss 16, Pp 17048-17059 (2019)
ACS Omega
ACS Omega
G protein-coupled receptors (GPCRs) are the largest family of membrane receptors and targets for approved drugs. Analysis of GPCR expression is thus important for drug discovery and typically involves mRNA-based methods. We compared transcriptomic cD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653968df4f67a23e4b4c5a89590aa6b5
Autor:
Chih-Min Tang, Phillippe Foubert, Evangeline Mose, Andrew M. Lowy, Dawn Jaquish, Michele L. Babicky, Megan M. Harper, Alex Cazes, Michael C. Schmid, Karen Messer, Patrick Holman, Randall French, Jaclyn Miyamoto, Susan E. Waltz, Judith A. Varner, Zakkary J Walterscheid, Jeffery Chakedis, Nissi Varki, Hakan Alakus, Betzaira G. Childers, Jason K. Sicklick
Publikováno v:
ONCOGENE
Oncogene, vol 38, iss 28
Oncogene
Oncogene, vol 38, iss 28
Oncogene
The MST1R (RON) kinase is overexpressed in >80% of human pancreatic cancers, but its role in pancreatic carcinogenesis is unknown. In this study, we examined the relevance of Mst1r kinase to Kras driven pancreatic carcinogenesis using genetically eng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebbd059e2304724657496e421fcd5c30
Autor:
Michael Hamilton, Trey Ideker, Haiyong Han, Sara Brin Rosenthal, Christian M. Schürch, Roman Sasik, Kathleen M. Fisch, Nikki K. Lytle, Andrew M. Lowy, Marcie Kritzik, Lourdes A Esparza, Wei Lin, Neil Robertson, Randall French, Nathan E. Lewis, L. Paige Ferguson, Evanthia Karamitopoulou, Philipp Spahn, Martin Wartenberg, Yutaka Shima, Micha Eichmann, Anagha Deshpande, Kathryn Gilroy, Peter D. Adams, José A. Galván, Raymond G. Fox, Inti Zlobec, Tami Gilderman, Tannishtha Reya, Aniruddha J. Deshpande, Pawan Noel, Daniel D. Von Hoff, Nirakar Rajbhandari
Publikováno v:
Cell, vol 177, iss 3
Drug resistance and relapse remain key challenges inpancreatic cancer. Here, we have used RNA sequencing (RNA-seq), chromatin immunoprecipitation (ChIP)-seq, and genome-wide CRISPR analysis to map the molecular dependencies of pancreatic cancer stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1439315728d601799b93bc272a2db8f9
https://escholarship.org/uc/item/1vq502nm
https://escholarship.org/uc/item/1vq502nm
Autor:
Paula Porras, Zakk Walterscheid, Dawn Jaquish, Jan Eickhoff, Michele L. Babicky, Evangeline Mose, Jeffery Chakedis, Andrew M. Lowy, Peter Cheng, Carsten Schultz-Fademrecht, Oliver Schadt, Randall French, Haleigh Howard, Christina Esdar, Jaclyn Miyamoto, Patrick Holman
Publikováno v:
Oncotarget
// Jeffery Chakedis 1 , Randall French 1 , Michele Babicky 1 , Dawn Jaquish 1 , Evangeline Mose 1 , Peter Cheng 1 , Patrick Holman 1 , Haleigh Howard 1 , Jaclyn Miyamoto 1 , Paula Porras 1 , Zakk Walterscheid 1 , Carsten Schultz-Fademrecht 2 , Christ