Development of a sandwich ELISA to detect Leishmania 40S ribosomal protein S12 antigen from blood samples of visceral leishmaniasis patients

Autor: Wen-Wei Zhang, Ayan Kumar Ghosh, Raodoh Mohamath, Jacqueline Whittle, Alessandro Picone, Patrick Lypaczewski, Momar Ndao, Randall F Howard, Pradeep Das, Steven G Reed, Greg Matlashewski

Publikováno v: BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-11 (2018)

Abstract Background Visceral leishmaniasis (VL), caused by Leishmania donovani complex parasites, is a neglected parasitic disease that is generally fatal if untreated. Despite decades of research to develop a sensitive VL diagnostic test, definitive

Externí odkaz: https://doaj.org/article/b29f35f943ef41a6be214c68c7c50f49

KSAC, a defined Leishmania antigen, plus adjuvant protects against the virulence of L. major transmitted by its natural vector Phlebotomus duboscqi.

Autor: Regis Gomes, Clarissa Teixeira, Fabiano Oliveira, Phillip G Lawyer, Dia-Eldin Elnaiem, Claudio Meneses, Yasuyuki Goto, Ajay Bhatia, Randall F Howard, Steven G Reed, Jesus G Valenzuela, Shaden Kamhawi

Publikováno v: PLoS Neglected Tropical Diseases, Vol 6, Iss 4, p e1610 (2012)

Recombinant KSAC and L110f are promising Leishmania vaccine candidates. Both antigens formulated in stable emulsions (SE) with the natural TLR4 agonist MPL® and L110f with the synthetic TLR4 agonist GLA in SE protected BALB/c mice against L. major i

Externí odkaz: https://doaj.org/article/66b7d8e5ac65409893efed54deb33b20

First-in-human, Randomized, Double-blind Clinical Trial of Differentially Adjuvanted PAMVAC, A Vaccine Candidate to Prevent Pregnancy-associated Malaria

Autor: Max Soegaard, Annette Knoblich, Willem A. de Jongh, Peter G. Kremsner, Nicaise Tuikue Ndam, Steven G. Reed, Lars Poulsen, Mihály Sulyok, Morten Nielsen, Odile Leroy, Mafalda Resende, Carlos Lamsfus Calle, Javier Ibáñez, Meral Esen, Ali Salanti, Thor G. Theander, Saadou Issifou, Randall F. Howard, Helle Holm Smedegaard, Benjamin Mordmüller, Mette H Jensen, Philippe Deloron, Sophie Houard, Charlotte Dyring, Adrian J. F. Luty, Diane Egger-Adam, Sisse B. Ditlev

Publikováno v: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Mordmüller, B, Sulyok, M, Egger-Adam, D, Resende, M, de Jongh, W A, Jensen, M H, Smedegaard, H H, Ditlev, S B, Soegaard, M, Poulsen, L, Dyring, C, Calle, C L, Knoblich, A, Ibáñez, J, Esen, M, Deloron, P, Ndam, N, Issifou, S, Houard, S, Howard, R F, Reed, S G, Leroy, O, Luty, A J F, Theander, T G, Kremsner, P G, Salanti, A & Nielsen, M A 2019, ' First-in-human, randomized, double-blind clinical trial of differentially adjuvanted PAMVAC, a vaccine candidate to prevent pregnancy-associated malaria ', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 69, no. 9, pp. 1509-1516 . https://doi.org/10.1093/cid/ciy1140

Background Malaria in pregnancy has major impacts on mother and child health. To complement existing interventions, such as intermittent preventive treatment and use of impregnated bed nets, we developed a malaria vaccine candidate with the aim of re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2527dce75d8d760dee04c009fb0a7b0
http://europepmc.org/articles/PMC6792113

Semi-quantitative measurement of asymptomatic L. infantum infection and symptomatic visceral leishmaniasis in dogs using Dual-Path Platform® CVL

Autor: Javan Esfandiari, Malcolm S. Duthie, Mandy Larson, Aarthy C. Vallur, Angela J. Toepp, Epid, Randall F. Howard, Christine A. Petersen, Benjamin Scott, Hailie Fowler, Melissa A. Kurtz

Publikováno v: Applied Microbiology and Biotechnology. 101:381-390

Infection with Leishmania causes diseases with variable presentation. The most severe form is visceral leishmaniasis (VL), caused by either L. donovani or L. infantum. Despite efforts to eliminate VL, to date, molecular detection in resource-poor set

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2fb293d2040c2f7ffb6c621ca18cfa
https://doi.org/10.1007/s00253-016-7925-6

Strategic evaluation of vaccine candidate antigens for the prevention of Visceral Leishmaniasis

Autor: Steven G. Reed, Michelle Favila, Raodoh Mohamath, Hong Liang, John D. Laurance, Kimberly A. Hofmeyer, Steven J. Reed, Rhea N. Coler, Aarthy C. Vallur, Yeung L. Tutterrow, H. Remy Bailor, Malcolm S. Duthie, Julie Vergara, Alessandro Picone, Jeffrey A. Guderian, Randall F. Howard

Publikováno v: Vaccine

Infection with Leishmania parasites results in a range of clinical manifestations and outcomes, the most severe of which is visceral leishmaniasis (VL). Vaccination will likely provide the most effective long-term control strategy, as the large numbe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1330152f16af4428ac9203f0df3213
https://doi.org/10.1016/j.vaccine.2016.04.067