Výsledky vyhledávání - "Randall E. Schreck"

Design, Synthesis, and Evaluations of Substituted 3-[(3- or 4-Carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as Inhibitors of VEGF, FGF, and PDGF Receptor Tyrosine Kinases

Autor: Kara Waltz, Audie Rice, Laura K. Shawver, Gerald Mcmahon, Congxin Liang, Ngoc Tran, Randall E. Schreck, Flora Tang, Li Sun, Cho Tang

Publikováno v: Journal of Medicinal Chemistry. 42:5120-5130

Receptor tyrosine kinases (RTKs) have been implicated as therapeutic targets for the treatment of human diseases including cancers, inflammatory diseases, cardiovascular diseases including arterial restenosis, and fibrotic diseases of the lung, liver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edec88d3ad110182ec5c97d4beccb110
https://doi.org/10.1021/jm9904295

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Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases

Autor: Kenneth Lipson, Li Sun, Ngoc Tran, Randall E. Schreck, Congxing Liang, Gerald McMahon, Steve Hubbard, Cho Tang, Flora Tang, Yong Zhou

Publikováno v: Journal of medicinal chemistry. 43(14)

A series of new 3-substituted indolin-2-ones containing a tetrahydroindole moiety was developed as specific inhibitors of receptor tyrosine kinases associated with VEGF-R, FGF-R, and PDGF-R growth factor receptors. These compounds were evaluated for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a82521000747419fd98eb6f05019da7
https://pubmed.ncbi.nlm.nih.gov/10893303

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