Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Randall D. McKinnon"'
Autor:
Randall D. McKinnon, Alyx T. Guarino
Publikováno v:
Brain Sciences, Vol 3, Iss 3, Pp 1215-1228 (2013)
At present there are no clinical therapies that can repair traumatic brain injury, spinal cord injury or degenerative brain disease. While redundancy and rewiring of surviving circuits can recover some lost function, the brain and spinal column lack
Externí odkaz:
https://doaj.org/article/715fc69d24bd43ac9cdd1505de5a4127
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 7, Pp 1281-1287 (2021)
We describe a pre-clinical spinal cord motor neuron injury model that is minimal invasive, reproducible, focal and easily applied to small rodents. Retrograde axonal transport of a pro-apoptotic phosphatidylinosotol 3’-kinase inhibitor, wortmannin,
Externí odkaz:
https://doaj.org/article/8ea831bcb3764ba6a092524641843c0a
Autor:
Randall D McKinnon
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 7, Pp 1448-1448 (2021)
Externí odkaz:
https://doaj.org/article/c5744ee0c85b4e51ab631cbabd4bbb2b
Autor:
Randall D. McKinnon, Danju Tso
Publikováno v:
Neural Regeneration Research, Vol 10, Iss 9, Pp 1356-1358 (2015)
Neural Regeneration Research
Neural Regeneration Research
The brain and spinal cord can not replace neurons or supporting glia that are lost through traumatic injury or disease. In pre-clinical studies, however, neural stem and progenitor cell transplants can promote functional recovery. Thus the central ne
Autor:
Mary E. Kiel, Dorota Sadowski, Marisa Apicella, Randall D. McKinnon, Cui Ping Chen, Aileen G. Arriola
Publikováno v:
Stem Cells and Development. 19:1343-1353
We describe a rapid and efficient 5-step program of defined factors for the genesis of brain myelin-forming oligodendrocytes (OLs) from embryonic stem cells (ESCs). The OLs emerge on the same time frame in vitro as seen in vivo. Factors promoting neu
Publikováno v:
Cell Research. 20:728-731
Adjunctive MSCs enhance myelin formation by xenogenic oligodendrocyte precursors transplanted in the retina
Publikováno v:
Stem Cells. 26:2229-2236
Embryonic stem cells (ESCs) hold great potential for therapeutic regeneration and repair in many diseases. However, many challenges remain before this can be translated into effective therapy. A principal and significant limit for outcome evaluations
Autor:
Juan-Pablo Labrador, Randall D. McKinnon, Greg J. Bashaw, John B. Thomas, Shingo Yoshikawa, David D. O'Keefe
Publikováno v:
Current Biology. 15(15):1413-1419
Summary Homeobox transcription-factor codes control motor-neuron subtype identity and dorsal versus ventral axon guidance in both vertebrate and invertebrate nervous systems [1–4]; however, the specific axon guidance-receptors that are regulated by
Publikováno v:
The Journal of Neuroscience. 25:3499-3508
Receptors with tyrosine kinase activity (RTKs) control tissue growth and development in metazoans. How they generate cell-specific responses remains essentially unknown; one model proposes that distinct RTKs activate different second-messenger pathwa
Publikováno v:
The Journal of Neuroscience. 23:7207-7217
Neurofibromatosis type 1 (NF1) patients are predisposed to learning disabilities, macrocephaly, and brain tumors as well as abnormalities on magnetic resonance imaging that are postulated to result from abnormal myelination. Here we show that Nf1 +/-