Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Randall B. Wilkening"'
Autor:
Miguel A Zarate, Stephanie R Wesolowski, Leanna M Nguyen, Robyn K De Dios, Randall B Wilkening, Paul J Rozance, Clyde J Wright
Publikováno v:
Innate Immunity, Vol 26 (2020)
Chorioamnionitis is associated with inflammatory end-organ damage in the fetus. Tissues in direct contact with amniotic fluid drive a pro-inflammatory response and contribute to this injury. However, due to a lack of direct contact with the amniotic
Externí odkaz:
https://doaj.org/article/b236a87782e2443f84341d5add34f443
Autor:
Hannah M. Kyllo, Dong Wang, Ramón A. Lorca, Colleen G. Julian, Lorna G. Moore, Randall B. Wilkening, Paul J. Rozance, Laura D. Brown, Stephanie R. Wesolowski
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism.
Glucose, lactate, and amino acids are major fetal nutrients. During placental insufficiency-induced intrauterine growth restriction (PI-IUGR), uteroplacental weight-specific oxygen consumption rates are maintained yet fetal glucose and amino acid sup
Autor:
Leanna M Nguyen, Clyde J. Wright, Robyn De Dios, Randall B. Wilkening, Stephanie R. Wesolowski, Miguel A Zarate, Paul J. Rozance
Publikováno v:
Innate Immunity, Vol 26 (2020)
Innate Immunity
Innate Immunity
Chorioamnionitis is associated with inflammatory end-organ damage in the fetus. Tissues in direct contact with amniotic fluid drive a pro-inflammatory response and contribute to this injury. However, due to a lack of direct contact with the amniotic
Autor:
Stephanie R. Wesolowski, Brittany Strahan, William W. Hay, Randall B. Wilkening, David A. Goldstrohm, Laura D. Brown, Paul J. Rozance, Melinda Sheffield-Moore, Giacomo Meschia, Melanie Cree-Green, Laura Zastoupil
Publikováno v:
The Journal of Physiology. 596:67-82
KEY POINTS Adults who were affected by intrauterine growth restriction (IUGR) suffer from reductions in muscle mass, which may contribute to insulin resistance and the development of diabetes. We demonstrate slower hindlimb linear growth and muscle p
Autor:
Laura D. Brown, William W. Hay, Randall B. Wilkening, Stephanie R. Thorn, Satya S. Houin, Paul J. Rozance
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 308:E306-E314
Reduced fetal glucose supply, induced experimentally or as a result of placental insufficiency, produces an early activation of fetal glucose production. The mechanisms and substrates used to fuel this increased glucose production rate remain unknown
Autor:
Paul J, Rozance, Laura, Zastoupil, Stephanie R, Wesolowski, David A, Goldstrohm, Brittany, Strahan, Melanie, Cree-Green, Melinda, Sheffield-Moore, Giacomo, Meschia, William W, Hay, Randall B, Wilkening, Laura D, Brown
Publikováno v:
The Journal of physiology. 596(1)
Adults who were affected by intrauterine growth restriction (IUGR) suffer from reductions in muscle mass, which may contribute to insulin resistance and the development of diabetes. We demonstrate slower hindlimb linear growth and muscle protein synt
Autor:
William W. Hay, Laura D. Brown, Jennifer L. Bruce, Stephanie R. Wesolowski, Sonnet S. Jonker, Joshua S. Benjamin, Christine Culpepper, Randall B. Wilkening, Paul J. Rozance
Hepatic glucose production (HGP) normally begins just prior to birth. Prolonged fetal hypoglycemia, intrauterine growth restriction, and acute hypoxemia produce an early activation of fetal HGP. To test the hypothesis that prolonged hypoxemia increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb4aa36f465723d546f7daceeba21ec
https://europepmc.org/articles/PMC4967231/
https://europepmc.org/articles/PMC4967231/
Autor:
Henry L. Galan, Barbra de Vrijer, Timothy R. H. Regnault, Frederick C. Battaglia, Cecilia Teng, Randall B. Wilkening
Publikováno v:
Experimental Biology and Medicine. 235:999-1006
In an ovine model of placental insufficiency-induced intrauterine growth retardation (PI-IUGR), characterized by hypoxia, hypoglycemia and a significant reduction in fetal weight, we assessed alterations in fetal and placental polyols. Arterial mater
Autor:
Jane Keng, Laura D. Brown, Stephanie R. Thorn, William W. Hay, Timothy R. H. Regnault, Michael Roper, Jacob E. Friedman, Paul J. Rozance, Randall B. Wilkening
Publikováno v:
Paediatrics Publications
Expression of key metabolic genes and proteins involved in mRNA translation, energy sensing, and glucose metabolism in liver and skeletal muscle were investigated in a late-gestation fetal sheep model of placental insufficiency intrauterine growth re
Autor:
B. de Vrijer, Timothy R. H. Regnault, Giacomo Meschia, Randall B. Wilkening, Henry L. Galan, Frederick C. Battaglia
Publikováno v:
Placenta. 28:714-723
Severe fetal growth restriction (FGR) is often associated with hypoxia. We studied FGR hypoxia in an experimental model which is produced by exposing pregnant ewes to a hyperthermic environment. The study utilized simultaneous measurements of several