Výsledky vyhledávání - "Randall B. Murphy"

Seizure Protection by Intrapulmonary Delivery of Propofol Hemisuccinate

Autor: Michael A. Rogawski, Randall B. Murphy, Dorota Zolkowska, Ashish Dhir

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 336:215-222

The lung provides a portal of entry for drug delivery that could be used to administer anticonvulsant substances to prevent or abort seizures. Here, we demonstrate that intrapulmonary propofol hemisuccinate (PHS) rapidly confers seizure protection in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2641953cd4f3811328262b76e7d6e6bc
https://doi.org/10.1124/jpet.110.173591

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Computed three-dimensional structures for theras-binding domain of theraf-p74 protein complexed withras-p21 and with its suppressor protein, rap-1A

Autor: Regina Monaco, Paul W. Brandt-Rauf, James M. Chen, Spero Manolatos, Randall B. Murphy, Matthew R. Pincus

Publikováno v: Journal of Protein Chemistry. 15:511-518

The three-dimensional structures of the ras-p21 protein and its protein inhibitor, rap-1A, have been computed bound to the ras-binding domain, RBD (residues 55-131), of the raf-p74 protein, a critical target protein of ras-p21 in the ras-induced mito

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https://doi.org/10.1007/bf01908532

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Purification, pharmacological characterization and photoaffinity labeling of sigma receptors from rat and bovine brain

Autor: Randall B. Murphy, David I. Schuster, Frank J. Arnold

Publikováno v: Brain Research. 670:14-28

The sigma receptor/binding site, found in the brain and periphery, binds haloperidol, (+)-benzomorphans, N-propyl-3-(3-hydroxyphenyl)-piperidine (3-PPP) and certain atypical neuroleptics with high affinity. We have succeeded in ca. 6,000-fold purific

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https://doi.org/10.1016/0006-8993(94)01123-y

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N-(1-Arylpropionyl)-4-aryltetrahydropyridines, a new class of high-affinity selective .sigma. receptor ligands

Autor: William Frietze, Guyanand Singh, Randall B. Murphy, George Stoupakis, David I. Schuster, George Lem, George K. Ehrlich, Yan Ping Pan, Bing Cai

Publikováno v: Journal of Medicinal Chemistry. 36:3923-3928

A series of N-(1-arylpropionyl)-4-aryl-1,2,3,6-tetrahydropyridines, prepared by simple Mannich condensations, have been found by radioligand binding assays to have moderate to high affinity (IC50 0.5-500 nM) for bovine cerebellar sigma receptor/bindi

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https://doi.org/10.1021/jm00076a021

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Octahydronaphthoquinolizines, a new biologically active tetracyclic ring system

Autor: David I. Schuster, Bing Cai, Yanping Pan, John C. Dewan, Randall B. Murphy, Donald J. Wink

Publikováno v: Tetrahedron Letters. 34:2067-2070

Unsubstituted and methoxy-substituted octahydronaphthoquinolizines, examples of new tetracyclic ring system, have been synthesized in three steps from corresponding 2-tetralones. The various diastereomers of each OHNQ have been separated and characte

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https://doi.org/10.1016/s0040-4039(00)60347-7

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ChemInform Abstract: Octahydronaphthoquinolizines, a New Biologically Active Tetracyclic Ring System

Autor: Yanping Pan, Donald J. Wink, John C. Dewan, Randall B. Murphy, Bing Cai, David I. Schuster

Publikováno v: ChemInform. 24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d5b12ebe72cdb5362d81df76f3f5717
https://doi.org/10.1002/chin.199334188

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ChemInform Abstract: N-(1-Arylpropionyl)-4-aryltetrahydropyridines, a New Class of High- Affinity Selective σ Receptor Ligands

Autor: Randall B. Murphy, G. Singh, Yanping Pan, Bing Cai, W. Frietze, George Lem, David I. Schuster, G. K. Ehrlich, G. Stoupakis

Publikováno v: ChemInform. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65bd3cb1df610471b1b63e2a1abf3a48
https://doi.org/10.1002/chin.199425139

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Enkephalin is a competitive antagonist of cholecystokinin in the gastrointestinal tract, as predicted from prior conformational analysis

Autor: James Gibbs, Randall B. Murphy, James M. Chen, Linda H. Schneider, Gerard P. Smith, Daryll C. Dykes, Matthew R. Pincus, Margery C. Beinfeld

Publikováno v: Journal of Protein Chemistry. 11:723-729

Prior calculations based on ECEPP (Empirical Conformational Energies for Peptides Program) of the low energy minima for cholecystokinin (CCK) and Met-enkephalin have demonstrated that significant structural features of these two peptides are identica

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https://doi.org/10.1007/bf01024973

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Evidence that the ras oncogene-encoded p21 protein induces oocyte maturation via activation of protein kinase C

Autor: Randall B. Murphy, Z Yamaizumi, Matthew R. Pincus, S Nishimura, P W Brandt-Rauf, I B Weinstein, Denise L. Chung

Publikováno v: Proceedings of the National Academy of Sciences. 89:1993-1996

The ras oncogene-encoded p21 protein is known to induce cell maturation of Xenopus laevis oocytes and malignant transformation of NIH 3T3 mouse fibroblasts. The pathways involved in oocytes and NIH 3T3 cells appear to be similar to one another. For e

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https://doi.org/10.1073/pnas.89.5.1993

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