Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Randal R. Ketchem"'
Autor:
Dirk Smith, Hannes Helgason, Patrick Sulem, Unnur Steina Bjornsdottir, Ai Ching Lim, Gardar Sveinbjornsson, Haruki Hasegawa, Michael Brown, Randal R Ketchem, Monica Gavala, Logan Garrett, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Asgeir Sigurdsson, Olafur T Magnusson, Gudmundur I Eyjolfsson, Isleifur Olafsson, Pall Torfi Onundarson, Olof Sigurdardottir, David Gislason, Thorarinn Gislason, Bjorn Runar Ludviksson, Dora Ludviksdottir, H Marike Boezen, Andrea Heinzmann, Marcus Krueger, Celeste Porsbjerg, Tarunveer S Ahluwalia, Johannes Waage, Vibeke Backer, Klaus A Deichmann, Gerard H Koppelman, Klaus Bønnelykke, Hans Bisgaard, Gisli Masson, Unnur Thorsteinsdottir, Daniel F Gudbjartsson, James A Johnston, Ingileif Jonsdottir, Kari Stefansson
Publikováno v:
PLoS Genetics, Vol 13, Iss 3, p e1006659 (2017)
IL-33 is a tissue-derived cytokine that induces and amplifies eosinophilic inflammation and has emerged as a promising new drug target for asthma and allergic disease. Common variants at IL33 and IL1RL1, encoding the IL-33 receptor ST2, associate wit
Externí odkaz:
https://doaj.org/article/e16a276b317c4e85bf2f763ea930be81
Autor:
Chelsey Bennett, Mcclure Megan J, Georgia D. Tomaras, Michael S. Seaman, Clark Rutilio H, Randal R. Ketchem, J. Alaina Floyd, Kelly E. Seaton, Christine C. Siska, Yan Brodsky, Jeremy M. Shaver, Bryan T. Mayer, Nicole L. Yates, Bruce A. Kerwin, Alison J. Gillespie
Publikováno v:
Journal of Pharmaceutical Sciences
The broadly neutralizing anti-HIV antibody, 10-1074, is a highly somatically hypermutated IgG1 being developed for prophylaxis in sub-Saharan Africa. A series of algorithms were applied to identify potentially destabilizing residues in the framework
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752f2582d80bda3c1169fc5c9a92aaad
http://europepmc.org/articles/PMC6941225
http://europepmc.org/articles/PMC6941225
Autor:
Amimeur Tileli, Clark Rutilio H, Josh Smith, Danielle Van Citters, Bruce A. Kerwin, Jeremy M. Shaver, Randal R. Ketchem, Christine C. Siska, Smidt Pauline S, Megan Sprague, Dean Pettit, J. Alex Taylor
We demonstrate the use of a Generative Adversarial Network (GAN), trained from a set of over 400,000 light and heavy chain human antibody sequences, to learn the rules of human antibody formation. The resulting model surpasses common in silico techni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13fde634263f9f22e3613107036384e
Publikováno v:
Development of Biopharmaceutical Drug-Device Products ISBN: 9783030314149
Multi-attribute method (MAM) is a mass spectrometry (MS)-based method that is used to directly characterize and monitor many product quality attributes and impurities on biotherapeutics. MAM utilizes high-resolution/accurate mass MS data. These data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5f818da71e97be6a564daa6f2aec193
https://doi.org/10.1007/978-3-030-31415-6_9
https://doi.org/10.1007/978-3-030-31415-6_9
Full-length immunoglobulins (Igs) are widely considered difficult to crystallize because of their large size, N-linked glycosylation, and flexible hinge region. However, numerous cases of intracellular Ig crystallization are reported in plasma cell d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f18bcf23c5151da87d95ed84854620
https://europepmc.org/articles/PMC5602423/
https://europepmc.org/articles/PMC5602423/
Autor:
Daniel F. Gudbjartsson, H. Marike Boezen, Monica Gavala, Adalbjorg Jonasdottir, Johannes Waage, Klaus A. Deichmann, Aslaug Jonasdottir, Asgeir Sigurdsson, Thorarinn Gislason, Haruki Hasegawa, Olafur Th Magnusson, Pall T. Onundarson, David Gislason, Gisli Masson, Michael Brown, Randal R. Ketchem, James A. Johnston, Kari Stefansson, Celeste Porsbjerg, Vibeke Backer, Unnur S. Bjornsdottir, Andrea Heinzmann, Dora Ludviksdottir, Logan Garrett, Marcus Krueger, Dirk E. Smith, Hans Bisgaard, Tarunveer S. Ahluwalia, Ai Ching Lim, Klaus Bønnelykke, Gardar Sveinbjornsson, Hannes Helgason, Gerard H. Koppelman, Ingileif Jonsdottir, Olof Sigurdardottir, Gudmundur I. Eyjolfsson, Unnur Thorsteinsdottir, Isleifur Olafsson, Bjorn R. Ludviksson, Patrick Sulem
Publikováno v:
PLoS genetics, 13(3), 1-24. PUBLIC LIBRARY SCIENCE
PLoS Genetics, Vol 13, Iss 3, p e1006659 (2017)
Smith, D, Helgason, H, Sulem, P, Bjornsdottir, U S, Lim, A C, Sveinbjornsson, G, Hasegawa, H, Brown, M, Ketchem, R R, Gavala, M, Garrett, L, Jonasdottir, A, Jonasdottir, A, Sigurdsson, A, Magnusson, O T, Eyjolfsson, G I, Olafsson, I, Onundarson, P T, Sigurdardottir, O, Gislason, D, Gislason, T, Ludviksson, B R, Ludviksdottir, D, Boezen, H M, Heinzmann, A, Krueger, M, Porsbjerg, C, Ahluwalia, T S, Waage, J, Backer, V, Deichmann, K A, Koppelman, G H, Bønnelykke, K, Bisgaard, H, Masson, G, Thorsteinsdottir, U, Gudbjartsson, D F, Johnston, J A, Jonsdottir, I & Stefansson, K 2017, ' A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma ', P L o S Genetics, vol. 13, no. 3, e1006659 . https://doi.org/10.1371/journal.pgen.1006659
PLoS Genetics
PLoS Genetics, Vol 13, Iss 3, p e1006659 (2017)
Smith, D, Helgason, H, Sulem, P, Bjornsdottir, U S, Lim, A C, Sveinbjornsson, G, Hasegawa, H, Brown, M, Ketchem, R R, Gavala, M, Garrett, L, Jonasdottir, A, Jonasdottir, A, Sigurdsson, A, Magnusson, O T, Eyjolfsson, G I, Olafsson, I, Onundarson, P T, Sigurdardottir, O, Gislason, D, Gislason, T, Ludviksson, B R, Ludviksdottir, D, Boezen, H M, Heinzmann, A, Krueger, M, Porsbjerg, C, Ahluwalia, T S, Waage, J, Backer, V, Deichmann, K A, Koppelman, G H, Bønnelykke, K, Bisgaard, H, Masson, G, Thorsteinsdottir, U, Gudbjartsson, D F, Johnston, J A, Jonsdottir, I & Stefansson, K 2017, ' A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma ', P L o S Genetics, vol. 13, no. 3, e1006659 . https://doi.org/10.1371/journal.pgen.1006659
PLoS Genetics
IL-33 is a tissue-derived cytokine that induces and amplifies eosinophilic inflammation and has emerged as a promising new drug target for asthma and allergic disease. Common variants at IL33 and IL1RL1, encoding the IL-33 receptor ST2, associate wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8bf9fd4475bc44e1cefedd75365983
https://research.rug.nl/en/publications/cbb66b9e-bd67-435c-806f-7f301357232f
https://research.rug.nl/en/publications/cbb66b9e-bd67-435c-806f-7f301357232f
Autor:
Kathy Manchulenko, Michael Brown, Cyr Clovis Chua De Imus, Ramil F. Latypov, Clark Rutilio H, Jane Carter, Zien Wilson, Randal R. Ketchem
Publikováno v:
mAbs
Therapeutic antibodies must encompass drug product suitable attributes to be commercially marketed. An undesirable antibody characteristic is the propensity to aggregate. Although there are computational algorithms that predict the propensity of a pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98da302b0e99854b390d342d97b0a9d
https://doi.org/10.4161/mabs.36252
https://doi.org/10.4161/mabs.36252
Autor:
Christopher E. Woods, Shradha Mishra, Randal R. Ketchem, Feng He, Bruce A. Kerwin, Jeremy D. Schmit
Publikováno v:
The Journal of Physical Chemistry B. 118:5044-5049
Antibody solutions are typically much more viscous than solutions of globular proteins at equivalent volume fraction. Here we propose that this is due to molecular entanglements that are caused by the elongated shape and intrinsic flexibility of anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ddda6515475ab52216ce77487ff095
https://doi.org/10.1021/jp500434b
https://doi.org/10.1021/jp500434b
Autor:
Jon Woodard, Randal R. Ketchem, Vladimir I. Razinkov, Ramil F. Latypov, Joanna L. Scavezze, Douglas D. Banks, Christine C. Siska
Publikováno v:
Journal of Pharmaceutical Sciences. 101:2720-2732
In the present report, two formulation strategies, based on different aggregation models, were compared for their ability to quickly predict which excipients (cosolutes) would minimize the aggregation rate of an immunoglobulin G1 monoclonal antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294d24b3ef41c9b388539cea11eb4901
https://doi.org/10.1002/jps.23219
https://doi.org/10.1002/jps.23219
Autor:
Kannan Gunasekaran, Zhonghua Hu, Boxu Yan, Zac Yates, Hongxing Zhou, Randal R. Ketchem, Zhi Liu
Publikováno v:
Journal of Biological Chemistry. 285:18662-18671
Hydroxyl radicals induce hinge cleavage in a human IgG1 molecule via initial radical formation at the first hinge Cys(231) followed by electron transfer to the upper hinge residues. To enable engineering of a stable monoclonal antibody hinge, we inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797249d010a2f2cb2cf895e83770cf1d
https://doi.org/10.1074/jbc.m110.108597
https://doi.org/10.1074/jbc.m110.108597