Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Randal O, Dull"'
Autor:
Randal O. Dull, Robert G. Hahn
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-10 (2023)
Abstract Fluid normally exchanges freely between the plasma and interstitial space and is returned primarily via the lymphatic system. This balance can be disturbed by diseases and medications. In inflammatory disease states, such as sepsis, the retu
Externí odkaz:
https://doaj.org/article/455183ae61dd411a8ac5dd0ac28b349f
Autor:
Randal O. Dull, Robert G. Hahn
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-8 (2022)
Abstract Preclinical studies in animals and human clinical trials question whether the endothelial glycocalyx layer is a clinically important permeability barrier. Glycocalyx breakdown products in plasma mostly originate from 99.6–99.8% of the endo
Externí odkaz:
https://doaj.org/article/699fdd8535c04d1083907ea7a7507124
Autor:
Robert G. Hahn, Randal O. Dull
Publikováno v:
Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract Background and aims Increased capillary filtration may paradoxically accelerate vascular refill of both fluid and albumin from the interstitial space, which is claimed to be edema-preventing. We characterized this proposed mechanism, called
Externí odkaz:
https://doaj.org/article/f06f86652ab74cf3bd5294c59fdcc6d4
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-9 (2017)
Abstract Background Heparanase, a mammalian endo-β-D-glucoronidase that specifically degrades heparan sulfate, has been implicated in inflammation and ischemic stroke. However, the role of heparanase in neuroinflammatory response in subarachnoid hem
Externí odkaz:
https://doaj.org/article/ccdb6ef60e784e2daea289dd0104506f
Autor:
Brant M Wagener, Parker J Hu, Joo-Yeun Oh, Cilina A Evans, Jillian R Richter, Jaideep Honavar, Angela P Brandon, Judy Creighton, Shannon W Stephens, Charity Morgan, Randal O Dull, Marisa B Marques, Jeffrey D Kerby, Jean-Francois Pittet, Rakesh P Patel
Publikováno v:
PLoS Medicine, Vol 16, Iss 11, p e1002991 (2019)
[This corrects the article DOI: 10.1371/journal.pmed.1002522.].
Externí odkaz:
https://doaj.org/article/784fd654e2c245219e86399b0c05c437
Autor:
Brant M Wagener, Parker J Hu, Joo-Yeun Oh, Cilina A Evans, Jillian R Richter, Jaideep Honavar, Angela P Brandon, Judy Creighton, Shannon W Stephens, Charity Morgan, Randal O Dull, Marisa B Marques, Jeffrey D Kerby, Jean-Francois Pittet, Rakesh P Patel
Publikováno v:
PLoS Medicine, Vol 15, Iss 3, p e1002522 (2018)
BACKGROUND:Trauma is the leading cause of death and disability in patients aged 1-46 y. Severely injured patients experience considerable blood loss and hemorrhagic shock requiring treatment with massive transfusion of red blood cells (RBCs). Preclin
Externí odkaz:
https://doaj.org/article/a5d757a669a44d178181118042a81522
Autor:
Randal O. Dull, Robert G. Hahn
Publikováno v:
Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-14 (2021)
Intensive Care Medicine Experimental
Intensive Care Medicine Experimental
Background and aims Increased capillary filtration may paradoxically accelerate vascular refill of both fluid and albumin from the interstitial space, which is claimed to be edema-preventing. We characterized this proposed mechanism, called “inters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e42156c724942872958f3f7c56d411
https://doaj.org/article/f06f86652ab74cf3bd5294c59fdcc6d4
https://doaj.org/article/f06f86652ab74cf3bd5294c59fdcc6d4
Autor:
Xueke Du, Chunling Jiang, Yang Lv, Randal O Dull, You-Yang Zhao, David E Schwartz, Guochang Hu
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180213 (2017)
A patient's recovery from lung inflammatory injury or development of multi-system organ failure is determined by the host's ability to resolve inflammation and repair tissue damage, both of which require the clearance of apoptotic neutrophils by macr
Externí odkaz:
https://doaj.org/article/61d48b6dfcff4b189436c255a636ad82
Publikováno v:
Journal of Vascular Research. 58:58-64
Syndecan-1 (Sdc-1) and glypican-1 (Gpc-1) are 2 important proteoglycans found in the glycocalyx and believed to govern transvascular distribution of fluid and protein. In this translational study, we assessed Sdc-1 and Gpc-1 knockout (KO) on whole bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef9a1b097164dd0bda400e72f867bad8
https://doi.org/10.1159/000510430
https://doi.org/10.1159/000510430
Autor:
Andreia Z. Chignalia, Randal O. Dull
Publikováno v:
Cardiovascular Engineering and Technology
Purpose Acute increases in hydrostatic pressure activate endothelial signaling pathways that modulate barrier function and vascular permeability. We investigated the role the glycocalyx and established mechanotransduction pathways in pressure-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f496fa73a1caa0aef5ac7464161e55cd
http://europepmc.org/articles/PMC7782381
http://europepmc.org/articles/PMC7782381