Deubiquitinase-targeting chimeras for targeted protein stabilization.

Autor: Henning NJ; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Innovative Genomics Institute, Berkeley, CA, USA., Boike L; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Innovative Genomics Institute, Berkeley, CA, USA., Spradlin JN; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Innovative Genomics Institute, Berkeley, CA, USA., Ward CC; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Innovative Genomics Institute, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Liu G; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Zhang E; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Innovative Genomics Institute, Berkeley, CA, USA., Belcher BP; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Innovative Genomics Institute, Berkeley, CA, USA., Brittain SM; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Hesse MJ; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Dovala D; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., McGregor LM; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Valdez Misiolek R; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Plasschaert LW; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Rowlands DJ; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Wang F; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Frank AO; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Novartis Institutes for BioMedical Research, Emeryville, CA, USA., Fuller D; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Estes AR; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Innovative Genomics Institute, Berkeley, CA, USA., Randal KL; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Innovative Genomics Institute, Berkeley, CA, USA., Panidapu A; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Innovative Genomics Institute, Berkeley, CA, USA., McKenna JM; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Tallarico JA; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Schirle M; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA.; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Nomura DK; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA. dnomura@berkeley.edu.; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, Berkeley, CA, USA. dnomura@berkeley.edu.; Innovative Genomics Institute, Berkeley, CA, USA. dnomura@berkeley.edu.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. dnomura@berkeley.edu.; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA. dnomura@berkeley.edu.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2022 Apr; Vol. 18 (4), pp. 412-421. Date of Electronic Publication: 2022 Feb 24.

Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex.

Autor: Xinle Zou, Shanmugam, Sri Karthika, Kanner, Scott A., Sampson, Kevin J., Kass, Robert S., Colecraft, Henry M.

Publikováno v: eLife; 9/13/2023, p1-19, 19p