Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Randal Halfmann"'
Autor:
Tej Kandola, Shriram Venkatesan, Jiahui Zhang, Brooklyn T Lerbakken, Alex Von Schulze, Jillian F Blanck, Jianzheng Wu, Jay R Unruh, Paula Berry, Jeffrey J Lange, Andrew C Box, Malcolm Cook, Celeste Sagui, Randal Halfmann
Publikováno v:
eLife, Vol 12 (2023)
A long-standing goal of amyloid research has been to characterize the structural basis of the rate-determining nucleating event. However, the ephemeral nature of nucleation has made this goal unachievable with existing biochemistry, structural biolog
Externí odkaz:
https://doaj.org/article/44add4460bad4d67966509cca5f76a90
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Deep learning methods that achieved great success in predicting intrachain residue-residue contacts have been applied to predict interchain contacts between proteins. However, these methods require multiple sequence alignments (MSAs) of a pa
Externí odkaz:
https://doaj.org/article/66f5d941ac704c18846c3af31b7d6767
Publikováno v:
eLife, Vol 11 (2022)
Immune cells activate in binary, switch-like fashion via large protein assemblies known as signalosomes, but the molecular mechanism of the switch is not yet understood. Here, we employed an in-cell biophysical approach to dissect the assembly mechan
Externí odkaz:
https://doaj.org/article/9c9c07aea5e14299b843d816a2923e33
Autor:
Michael J. Holliday, Axel Witt, Alejandro Rodríguez Gama, Benjamin T. Walters, Christopher P. Arthur, Randal Halfmann, Alexis Rohou, Erin C. Dueber, Wayne J. Fairbrother
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
CARD9 and CARD11 propagate signaling by nucleating Bcl10 polymerization in immune cells and are both held in an autoinhibited state prior to activation. Here, the authors combine structural, biochemical, and cell-based approaches to reveal the struct
Externí odkaz:
https://doaj.org/article/7e23aebac6c444bc92a15b78399d9b56
Autor:
Nicole L Nuckolls, Anthony C Mok, Jeffrey J Lange, Kexi Yi, Tejbir S Kandola, Andrew M Hunn, Scott McCroskey, Julia L Snyder, María Angélica Bravo Núñez, Melainia McClain, Sean A McKinney, Christopher Wood, Randal Halfmann, Sarah E Zanders
Publikováno v:
eLife, Vol 9 (2020)
Meiotic drivers are parasitic loci that force their own transmission into greater than half of the offspring of a heterozygote. Many drivers have been identified, but their molecular mechanisms are largely unknown. The wtf4 gene is a meiotic driver i
Externí odkaz:
https://doaj.org/article/1560ca6d7fc8488d95b7f94f13bf5508
Autor:
Xiao-Feng Zhang, Rong Sun, Qin Guo, Shaoyan Zhang, Tea Meulia, Randal Halfmann, Dawei Li, Feng Qu
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006253 (2017)
Diverse animal and plant viruses block the re-infection of host cells by the same or highly similar viruses through superinfection exclusion (SIE), a widely observed, yet poorly understood phenomenon. Here we demonstrate that SIE of turnip crinkle vi
Externí odkaz:
https://doaj.org/article/199858d3ecd449b094964e928a0e1637
Publikováno v:
Molecular Biology of the Cell. 34
Proteins with complex phase behavior are difficult to study in cells due to low throughput and resolution of fluorescence microscopy. Miller et al. modify a flow cytometry assay–Distribued Amphifluoric FRET (DAmFRET)–to better address this challe
Publikováno v:
Biophysical Journal. 120:1150-1160
Innate immune responses, such as cell death and inflammatory signaling, are typically switch-like in nature. They also involve "prion-like" self-templating polymerization of one or more signaling proteins into massive macromolecular assemblies known
Autor:
Randal Halfmann, Tej Kandola, Shriram Venkatesan, Jaihui Zhang, Brooklyn Lerbakken, Jillian F. Blanck, Jianzheng Wu, Jay Unruh, Paula Berry, Jeffrey J. Lange, Alex Von Schulze, Andrew Box, Malcolm Cook, Celeste Sagui
Publikováno v:
The FASEB Journal. 36